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Ítem Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America(Wiley, 2026) Nieto, Romina; Hernández, Lucia; Quintana, Rosana; Fernández ávila, Diana; Palacios Santillán, Erika; Subils, Gisela; Otaduy, Cintia; Saurith, Verónica; Arturi, Valeria; Sattler, María E.; González Lucero, Luciana; Patiño Grageda, Wilfredo; Pérez, Nicolás; Cosatti, Micaela; Crespo Espindola, María E.; Martínez Serventi, Joaquín; De Oliveira, Ana Carolina; Montandon, Silva; Aline Gasparin, Andrese; Duarte, Angela; Alvino, Laissa; Borba, Eduardo F.; Parente, Luciana; Torres dos Reis Neto, Edgard; Guerra Herrera, Iris; Massardo, Loreto; Aroca Martínez, Gustavo; Medina, Hellen; Cañas Davila, Carlos A.; Quintana-Lopez, Gerardo; Toro-Gutiérrez, Carlos E.; Martínez, José; Sánchez Briones, Reyna E.; Pérez Cristóbal, Mario; Martin-Nares, Eduardo; Juárez-Vicuña, Yaneli; García De La Torre, Ignacio; Abud Mendoza, Carlos; Esquivel-Valerio, Jorge A.; Langjahr, Patricia; Vazquez, Marcos A.; Cieza Calderón, Jorge N.; Ugarte-Gil, Manuel F.; Calvo Quiroz, Armando; Pizzarossa, Carina; Danza, Álvaro; Gómez-Puerta, José A.; Pons-Estel, Bernardo A.; Pons Estel, Guillermo J.; Peláez-Ballestas, IngrisObjective The objective of this study is to perform a cross-cultural validation of the Work Productivity and Activity Impairment (WPAI-Lupus v2.0) questionnaire in Latin American individuals with systemic lupus erythematosus (SLE), using data from the GLADEL cohort. Methods GLADEL 2.0 is an observational cohort of SLE patients ≥ 18 years old. Clinical data, disease activity (SLEDAI-2 K), damage index (SDI), physician's global assessment (PGA) and patient-reported outcomes (WPAI-Lupus v2.0, LupusQoL), were assessed at baseline and during follow-up. Construct validity was evaluated through Spearman correlations with SLEDAI-2 K, SDI and LupusQoL. Internal consistency was assessed using Cronbach's alpha and responsiveness over 12 months was analyzed using the Wilcoxon signed-rank test. Appropriate statistical tests (p < 0.05) were performed using R software, version 4.4.0. Results Among 1083 patients, 684 were evaluated at baseline and at 12 months. Cronbach's alpha values were: absenteeism 0.54; presenteeism 0.64; overall work impairment 0.62; activity impairment 0.62. WPAI-Lupus v2.0 scores correlated with SLEDAI-2 K (p < 0.001) and negatively with LupusQoL domains. Moderate correlations were observed between activity impairment and physical health, pain and planning (r ≈ −0.52 to −0.58). Presenteeism and overall work impairment also showed moderate correlations with physical health and pain domains (r ≈ −0.49 to −0.53). WPAI-Lupus v2.0 was sensitive to change over 12 months (p = 0.001) for all domains except intimate relationship.