Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America
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Fecha
2026
Autores
Nieto, Romina
Hernández, Lucia
Quintana, Rosana
Fernández ávila, Diana
Palacios Santillán, Erika
Subils, Gisela
Otaduy, Cintia
Saurith, Verónica
Arturi, Valeria
Sattler, María E.
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Wiley
Resumen
Objective
The objective of this study is to perform a cross-cultural validation of the Work Productivity and Activity Impairment (WPAI-Lupus v2.0) questionnaire in Latin American individuals with systemic lupus erythematosus (SLE), using data from the GLADEL cohort.
Methods
GLADEL 2.0 is an observational cohort of SLE patients ≥ 18 years old. Clinical data, disease activity (SLEDAI-2 K), damage index (SDI), physician's global assessment (PGA) and patient-reported outcomes (WPAI-Lupus v2.0, LupusQoL), were assessed at baseline and during follow-up. Construct validity was evaluated through Spearman correlations with SLEDAI-2 K, SDI and LupusQoL. Internal consistency was assessed using Cronbach's alpha and responsiveness over 12 months was analyzed using the Wilcoxon signed-rank test. Appropriate statistical tests (p < 0.05) were performed using R software, version 4.4.0.
Results
Among 1083 patients, 684 were evaluated at baseline and at 12 months. Cronbach's alpha values were: absenteeism 0.54; presenteeism 0.64; overall work impairment 0.62; activity impairment 0.62. WPAI-Lupus v2.0 scores correlated with SLEDAI-2 K (p < 0.001) and negatively with LupusQoL domains. Moderate correlations were observed between activity impairment and physical health, pain and planning (r ≈ −0.52 to −0.58). Presenteeism and overall work impairment also showed moderate correlations with physical health and pain domains (r ≈ −0.49 to −0.53). WPAI-Lupus v2.0 was sensitive to change over 12 months (p = 0.001) for all domains except intimate relationship.
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Citación
R. E.Nieto, L.Hernández, R.Quintana, et al., “Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America,” International Journal of Rheumatic Diseases29, no. 4 (2026): e70641, https://doi.org/10.1111/1756-185x.70641.