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Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America

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datacite.rightshttp://purl.org/coar/access_right/c_abf2
dc.contributor.authorNieto, Romina
dc.contributor.authorHernández, Lucia
dc.contributor.authorQuintana, Rosana
dc.contributor.authorFernández ávila, Diana
dc.contributor.authorPalacios Santillán, Erika
dc.contributor.authorSubils, Gisela
dc.contributor.authorOtaduy, Cintia
dc.contributor.authorSaurith, Verónica
dc.contributor.authorArturi, Valeria
dc.contributor.authorSattler, María E.
dc.contributor.authorGonzález Lucero, Luciana
dc.contributor.authorPatiño Grageda, Wilfredo
dc.contributor.authorPérez, Nicolás
dc.contributor.authorCosatti, Micaela
dc.contributor.authorCrespo Espindola, María E.
dc.contributor.authorMartínez Serventi, Joaquín
dc.contributor.authorDe Oliveira, Ana Carolina
dc.contributor.authorMontandon, Silva
dc.contributor.authorAline Gasparin, Andrese
dc.contributor.authorDuarte, Angela
dc.contributor.authorAlvino, Laissa
dc.contributor.authorBorba, Eduardo F.
dc.contributor.authorParente, Luciana
dc.contributor.authorTorres dos Reis Neto, Edgard
dc.contributor.authorGuerra Herrera, Iris
dc.contributor.authorMassardo, Loreto
dc.contributor.authorAroca Martínez, Gustavo
dc.contributor.authorMedina, Hellen
dc.contributor.authorCañas Davila, Carlos A.
dc.contributor.authorQuintana-Lopez, Gerardo
dc.contributor.authorToro-Gutiérrez, Carlos E.
dc.contributor.authorMartínez, José
dc.contributor.authorSánchez Briones, Reyna E.
dc.contributor.authorPérez Cristóbal, Mario
dc.contributor.authorMartin-Nares, Eduardo
dc.contributor.authorJuárez-Vicuña, Yaneli
dc.contributor.authorGarcía De La Torre, Ignacio
dc.contributor.authorAbud Mendoza, Carlos
dc.contributor.authorEsquivel-Valerio, Jorge A.
dc.contributor.authorLangjahr, Patricia
dc.contributor.authorVazquez, Marcos A.
dc.contributor.authorCieza Calderón, Jorge N.
dc.contributor.authorUgarte-Gil, Manuel F.
dc.contributor.authorCalvo Quiroz, Armando
dc.contributor.authorPizzarossa, Carina
dc.contributor.authorDanza, Álvaro
dc.contributor.authorGómez-Puerta, José A.
dc.contributor.authorPons-Estel, Bernardo A.
dc.contributor.authorPons Estel, Guillermo J.
dc.contributor.authorPeláez-Ballestas, Ingris
dc.date.accessioned2026-04-23T20:12:10Z
dc.date.available2026-04-23T20:12:10Z
dc.date.issued2026
dc.description.abstractObjective The objective of this study is to perform a cross-cultural validation of the Work Productivity and Activity Impairment (WPAI-Lupus v2.0) questionnaire in Latin American individuals with systemic lupus erythematosus (SLE), using data from the GLADEL cohort. Methods GLADEL 2.0 is an observational cohort of SLE patients ≥ 18 years old. Clinical data, disease activity (SLEDAI-2 K), damage index (SDI), physician's global assessment (PGA) and patient-reported outcomes (WPAI-Lupus v2.0, LupusQoL), were assessed at baseline and during follow-up. Construct validity was evaluated through Spearman correlations with SLEDAI-2 K, SDI and LupusQoL. Internal consistency was assessed using Cronbach's alpha and responsiveness over 12 months was analyzed using the Wilcoxon signed-rank test. Appropriate statistical tests (p < 0.05) were performed using R software, version 4.4.0. Results Among 1083 patients, 684 were evaluated at baseline and at 12 months. Cronbach's alpha values were: absenteeism 0.54; presenteeism 0.64; overall work impairment 0.62; activity impairment 0.62. WPAI-Lupus v2.0 scores correlated with SLEDAI-2 K (p < 0.001) and negatively with LupusQoL domains. Moderate correlations were observed between activity impairment and physical health, pain and planning (r ≈ −0.52 to −0.58). Presenteeism and overall work impairment also showed moderate correlations with physical health and pain domains (r ≈ −0.49 to −0.53). WPAI-Lupus v2.0 was sensitive to change over 12 months (p = 0.001) for all domains except intimate relationship.eng
dc.format.mimetypehttp
dc.identifier.citationR. E.Nieto, L.Hernández, R.Quintana, et al., “Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America,” International Journal of Rheumatic Diseases29, no. 4 (2026): e70641, https://doi.org/10.1111/1756-185x.70641.
dc.identifier.doihttps://doi.org/10.1111/1756-185x.70641
dc.identifier.issn1756-185X (electrónico)
dc.identifier.issn1756-1841 (Impreso)
dc.identifier.urihttps://hdl.handle.net/20.500.12442/17581
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70641
dc.language.isoeng
dc.publisherWileyspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceInternational Journal Rheumatic Diseaseseng
dc.sourceVol. 29  No. 4 Año  2026spa
dc.titleCross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin Americaeng
dc.type.driverinfo:eu-repo/semantics/article
dc.type.spaArtículo científico
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