Infective endocarditis in the colombian caribbean region: clinical profile, microbiological insights, and risk factors for mortality
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | spa |
| dc.contributor.author | Solarte Bastidas, Gabriela | |
| dc.contributor.author | Herrera Calle, Pedro | |
| dc.contributor.author | Domínguez-Vargas, Alex | |
| dc.contributor.author | Iglesias Pertuz, Shirley | |
| dc.contributor.author | González-Torres, Henry J. | |
| dc.date.accessioned | 2024-01-16T14:47:24Z | |
| dc.date.available | 2024-01-16T14:47:24Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Infective endocarditis (IE) is defined as the infectious and inflammatory process of the heart’s internal structures. It can be caused by a broad group of bacteria and, rarely, fungi, with potentially life-threatening consequences. Objective: To profile bacterial resistance and identify mortality risk factors in IE patients. Methods: This crosssectional study included clinically diagnosed IE patients. Sociodemographic, comorbidity, clinical, and microbiological data were recorded. Descriptive analyses, Chi-Square/Fisher’s exact tests, and Student’s t-tests examined variables in relation to IE outcomes (survival vs. mortality). Multivariate logistic regression calculated odds ratios and confidence intervals. Results: We enrolled 39 patients (mean age 51 ± 19.5 years, 54 % male). Common comorbidities included acute kidney injury (AKI) (46 %), heart failure (26 %), and ischemic stroke (21 %). Deceased patients had higher rates of fatigue (p=0.03), lower limb edema (p=0.01), and AKI (p=0.01) than survivors. Fifteen (38 %) patients had positive cultures; Staphylococcus aureus predominated in survivors (13 %) and deceased (13 %) patients (p=0.06). Multi-drug-resistant bacteria were found in six (15 %) patients, and one (2.6 %) had Extensively Drug-Resistant bacteria. Multivariate Logistic Regression indicated that lower limb edema (OR 8.6, 95 % CI 1.5–49, p=0.01), and AKI (OR 7.8, 95 % CI 1.65–37.2, p=0.01) increased mortality risk in IE patients. Conclusion: In this study, lower limb edema and AKI were significant predictors of mortality in IE patients, emphasizing their clinical importance in IE progression and resolution. Further research should explore additional variables and risk factors to enhance our ability to predict and manage outcomes in this population. | eng |
| dc.description.abstract | La endocarditis infecciosa (EI) se define como el proceso infeccioso e inflamatorio de las estructuras internas del corazón. Puede ser causada por un amplio grupo de bacterias y, rara vez, por hongos, con consecuencias potencialmente mortales. Objetivo: perfilar la resistencia bacteriana e identificar factores de riesgo de mortalidad en pacientes con EI. Métodos: Este estudio transversal incluyó pacientes con EI clínicamente diagnosticada. Se registraron datos sociodemográficos, de comorbilidad, clínicos y microbiológicos. Los análisis descriptivos, las pruebas de Chi-Cuadrado/exactas de Fisher y las pruebas t de Student examinaron las variables en relación con los resultados de IE (supervivencia versus mortalidad). La regresión logística multivariada calculó los Odds ratios y los intervalos de confianza. Resultados: Se incluyeron 39 pacientes (edad media 51 ± 19,5 años, 54 % hombres). Las comorbilidades comunes incluyeron lesión renal aguda (IRA) (46 %), insuficiencia cardíaca (26 %) y accidente cerebrovascular isquémico (21 %). Los pacientes fallecidos tuvieron tasas más altas de fatiga (p=0,03), edema de miembros inferiores (p=0,01) y IRA (p=0,01) que los supervivientes. Quince (38 %) pacientes tuvieron cultivos positivos; Staphylococcus aureus predominó en los pacientes sobrevivientes (13 %) y fallecidos (13 %) (p=0,06). Se encontraron bacterias multirresistentes en seis (15 %) pacientes y uno (2,6 %) tenía bacterias extremadamente resistentes a los medicamentos. La regresión logística multivariada indicó que el edema de las extremidades inferiores (OR 8,6, IC 95 % 1,5–49, p = 0,01) y la IRA (OR 7,8, IC 95 % 1,65–37,2, p = 0,01) aumentaron el riesgo de mortalidad en pacientes con EI. Conclusión: En este estudio, el edema de las extremidades inferiores y la IRA fueron predictores significativos de mortalidad en pacientes con EI, enfatizando su importancia clínica en la progresión y resolución de la EI. Investigaciones adicionales deberían explorar variables y factores de riesgo adicionales para mejorar nuestra capacidad de predecir y gestionar los resultados en esta población. | spa |
| dc.format.mimetype | spa | |
| dc.identifier.doi | 10.47307/GMC.2023.131.4.17 | |
| dc.identifier.issn | 27390012 | |
| dc.identifier.issn | 27390012 (en línea) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/13782 | |
| dc.identifier.url | http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/27488/144814493246 | |
| dc.language.iso | eng | eng |
| dc.publisher | ACADEMIA NACIONAL DE MEDICINA | spa |
| dc.publisher | Facultad de Ciencias de la Salud | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Gaceta Médica de Caracas | spa |
| dc.source | Gac Méd Caracas | spa |
| dc.source | Vol. 131 No. 4 (2023) | |
| dc.subject | Infective endocarditis | eng |
| dc.subject | Outcome | eng |
| dc.subject | Antimicrobial resistance | eng |
| dc.subject | Heart failure | eng |
| dc.subject | Endocarditis infecciosa | spa |
| dc.subject | Resultado | spa |
| dc.subject | Resistencia antimicrobiana | spa |
| dc.subject | Insuficiencia cardíaca | spa |
| dc.title | Infective endocarditis in the colombian caribbean region: clinical profile, microbiological insights, and risk factors for mortality | eng |
| dc.title.translated | Endocarditis infecciosa en la región caribe colombiana: Perfil clínico, conocimientos microbiológicos y factores de riesgo de mortalidad | spa |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.spa | Artículo científico | spa |
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| oaire.version | info:eu-repo/semantics/publishedVersion | spa |
| sb.programa | Especialización en Medicina Interna | spa |
| sb.sede | Sede Barranquilla |