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Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus

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dc.contributor.authorNavarro Quiroz, Elkin
dc.contributor.authorNavarro Quiroz, Roberto
dc.contributor.authorPacheco Lugo, Lisandro
dc.contributor.authorAroca Martínez, Gustavo
dc.contributor.authorGómez Escorcia, Lorena
dc.contributor.authorGonzalez Torres, Henry
dc.contributor.authorCadena Bonfanti, Andres
dc.contributor.authorMarmolejo, Maria del Carmen
dc.contributor.authorSanchez, Eduardo
dc.contributor.authorVillarreal Camacho, Jose Luis
dc.contributor.authorLorenzi, Hernan
dc.contributor.authorTorres, Augusto
dc.contributor.authorNavarro, Kelvin Fernando
dc.contributor.authorNavarro Rodriguez, Pablo
dc.contributor.authorVilla, Joe Luis
dc.contributor.authorFernández- Ponce, Cecilia
dc.date.accessioned2019-06-26T14:34:14Z
dc.date.available2019-06-26T14:34:14Z
dc.date.issued2019
dc.description.abstractThe aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone modifications in systemic lupus erythematosus (SLE). To identify miRNA dysregulation in SLE, we used miR2Disease and PhenomiR for information about miRNAs exhibiting differential regulation in disease and other biological processes, and HMDD for information about experimentally supported human miRNA–disease association data from genetics, epigenetics, circulating miRNAs, and miRNA–target interactions. This information was incorporated into the miRNA analysis. High-throughput sequencing revealed circulating miRNAs associated with kidney damage in patients with SLE. As the main finding of our in silico analysis of miRNAs differentially expressed in SLE and their interactions with disease-susceptibility genes, post-translational modifications, and transcription factors; we highlight 226 miRNAs associated with genes and processes. Moreover, we highlight that alterations of miRNAs such as hsa-miR-30a-5p, hsa-miR-16-5p, hsa-miR-142-5p, and hsa-miR-324-3p are most commonly associated with post-translational modifications. In addition, altered miRNAs that are most frequently associated with susceptibility-related genes are hsa-miR-16-5p, hsamiR- 374a-5p, hsa-miR-34a-5p, hsa-miR-31-5p, and hsa-miR-1-3p.eng
dc.identifier.issn19326203
dc.identifier.urihttps://hdl.handle.net/20.500.12442/3358
dc.language.isoengeng
dc.publisherPublic Library of Scienceeng
dc.publisherFacultad de Ciencias Básicas y Biomédicas
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcePLoS ONEeng
dc.source.urihttps://doi.org/10.1371/journal.pone.0218116eng
dc.subjectMicroRNAseng
dc.subjectSystemic lupus erythematosuseng
dc.subjectDNA methylationeng
dc.subjectPost-translational modificationeng
dc.subjectEpigeneticseng
dc.subjectTranscription factorseng
dc.subjectGene regulationeng
dc.titleIntegrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosuseng
dc.typearticleeng
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sb.programaMaestría en Genética
sb.sedeSede Barranquilla

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