Biomarcadores de respuesta inmune celular asociados con enfermedades crónicas no transmisibles
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Fecha
2020-06
Autores
Acosta Redondo, Luz Dayana
Guzman Padilla, Alvaro Yesid
Padilla Ojeda, Kenneth David
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
La respuesta adaptativa celular tiene como propósito fundamental la
generación y liberación de Citocinas, moléculas de naturaleza proteica o
glicoproteica que cumplen diversidad de funciones y son potencializadoras de
todas las respuestas inmunes, siendo mayormente producidas por Linfocitos
TCD4+ de todas las subpoblaciones, resultando más determinantes las
generadas por los Th1 y Th2. Las citocinas actúan fundamentalmente como
reguladores de las respuestas inmunitaria e inflamatoria. Esta respuesta
resulta determinante en un sinnúmero de eventos y complicaciones, no siendo
ajenas las enfermedades crónicas no trasmisibles. En el presente trabajo se
pretende establecer el patrón de respuesta inmune adaptativa mediante el
estudio de los niveles de interleucinas Th1 y Th2 en pacientes con
enfermedades crónicas no transmisibles (ECNT) como Hipertensión Arterial
(HTA), Diabetes Mellitus tipo 2 (DM2) y Cáncer para establecer la asociación
de estas como Bio-marcadores de respuesta adaptativa celular y propender
por la reducción de los índices de morbilidad y mortalidad en los individuos
afectados.
The cellular adaptive response has as its fundamental purpose the generation and release of Cytokines, molecules of a protein or glycoprotein nature that fulfill a variety of functions and are potentiators of all immune responses, being mainly produced by TCD4 lymphocytes from all subpopulations, the generated by Th1 and Th2. Cytokines primarily act as regulators of immune and inflammatory responses. This response is decisive in countless events and complications, and non-communicable chronic diseases are not foreign. The present work aims to establish the adaptive immune response pattern by studying the levels of Th1 and Th2 interleukins in patients with chronic noncommunicable diseases such as Arterial Hypertension (AHT), Diabetes Mellitus type 2 (DM2) and Cancer in the city. from Barranquilla, Colombia during the period 2019 - 2020, to establish the association of these as Bio-markers of cellular adaptive response and promote the reduction of morbidity and mortality rates in affected individuals.
The cellular adaptive response has as its fundamental purpose the generation and release of Cytokines, molecules of a protein or glycoprotein nature that fulfill a variety of functions and are potentiators of all immune responses, being mainly produced by TCD4 lymphocytes from all subpopulations, the generated by Th1 and Th2. Cytokines primarily act as regulators of immune and inflammatory responses. This response is decisive in countless events and complications, and non-communicable chronic diseases are not foreign. The present work aims to establish the adaptive immune response pattern by studying the levels of Th1 and Th2 interleukins in patients with chronic noncommunicable diseases such as Arterial Hypertension (AHT), Diabetes Mellitus type 2 (DM2) and Cancer in the city. from Barranquilla, Colombia during the period 2019 - 2020, to establish the association of these as Bio-markers of cellular adaptive response and promote the reduction of morbidity and mortality rates in affected individuals.
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Palabras clave
Linfocitos, Citocinas, Cáncer, Biomarcadores, Diabetes tipo 2