Examinando por Autor "Navarro Quiroz, Roberto"
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Ítem Avances investigativos en nefritis lúpica(Ediciones Universidad Simón Bolívar, 2020) Aroca Martínez, Gustavo; Vélez-Verbel, María D.; González-Torres, Henry J.; De La Cruz, Fernando; Navarro Quiroz, Roberto; Navarro Quiroz, Elkin; Pacheco Lugo, Lisandro; Arrieta Bravo, Valentina; Díaz Olmos, Yirys; Gómez Escorcia, Lorena; Acosta-Hoyos, Antonio J.El lupus eritematoso sistémico (LES) es una enfermedad autoinmune recurrente-remitente caracterizada por la pérdida de tolerancia a los ácidos nucleicos y manifestaciones clínicas muy diversas. la heterogeneidad clínica, junto con la posible gravedad de estas manifestaciones, hacen que el tratamiento del LES sea un desafío distinto. A pesar de los avances recientes en los protocolos de tratamiento, varios estudios han señalado que los pacientes con LES todavía tienen un riesgo general de muertes de 2 a 3 veces mayor. Adicionalmente, existe grandes desafíos a nivel diagnóstico y la búsqueda de biomarcadores que permitan una rápida detención de afecciones como la real. El libro Avances Investigativos en Nefritis Lúpica compila conocimientos recientes sobre la base genética, molecular de la nefritis lúpica, nuevos biomarcadores diagnóstico, su potencial uso y el rol de las infecciones en esta enfermedad.Ítem Cell Signaling in Neuronal Stem Cells(MDPI, 2018-07) Navarro Quiroz, Elkin; Navarro Quiroz, Roberto; Ahmad, Mostapha; Gomez Escorcia, Lorena; Villarreal, Jose Luis; Fernandez Ponce, Cecilia; Aroca Martinez, GustavoThe defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).Ítem Eficiencia del uso de apósitos de Biocelulosa en la curación de heridas por pie diabético de pacientes con un diagnóstico de diabetes mellitus tipo II en una IPS de la ciudad de Barranquilla Colombia en el periodo comprendido marzo de 2018 a marzo de 2019(Ediciones Universidad Simón Bolívar, 2019) Ariza Miranda, Luis Eduardo; Arrieta de Avila, Karla Julieth; Ayala Pérez, Jessica Andrea; Morales Cervantes, Maricela; Navarro Quiroz, Elkin; Navarro Quiroz, RobertoLa diabetes mellitus (DM) es una enfermedad multifactorial compleja y heterogénea en la que factores genéticos y epigenéticos interactúan con un ambiente toxico que promueve el desarrollo de obesidad y resistencia insulínica. Debemos considerarla como la primera causa de amputación no traumática de miembros inferiores, debido a complicaciones como el pie diabético. El objetivo de este trabajo es evaluar la eficiencia del uso de apósitos de biocelulosa en la curación de heridas por pie diabético de pacientes con un diagnóstico de diabetes mellitus tipo II en una IPS de Barranquilla Colombia en el periodo comprendido marzo de 2018 a marzo a 2019. Para ello, se seleccionaron pacientes de la consulta de la especialidad de medicina interna de una IPS de Barranquilla, teniendo en cuenta la periodicidad de ingreso de nuevos pacientes, durante el año 2018 se espera alcanzar una muestra total representativa de aproximadamente 50 pacientes con diagnostico de diabetes y con complicaciones por pie diabético de los cuales 25 pacientes se les implemento terapia con apósitos de biocelulosa y a los 25 restantes terapia con curaciones convencionales, es un estudio experimentalÍtem Epidemiology and Toxicology of Ciguatera Poisoning in the Colombian Caribbean(MDPI, 2020) Navarro Quiroz, Roberto; Herrera-Usuga, Juan Carlos; Osorio-Ospina, Laura Maria; Garcia-Pertuz, Katia Margarita; Navarro Quiroz, ElkinCiguatera is a food intoxication caused by the consumption of primarily coral fish; these species exist in large numbers in the seas that surround the Colombian territory. The underreported diagnosis of this clinical entity has been widely highlighted due to multiple factors, such as, among others, ignorance by the primary care practitioner consulted for this condition as well as clinical similarity to secondary gastroenteric symptoms and common food poisonings of bacterial, parasitic or viral etiology. Eventually, it was found that people a ected by ciguatoxins had trips to coastal areas hours before the onset of symptoms. Thanks to multiple studies over the years, it has been possible to identify the relation between toxigenic dinoflagellates and seagrasses, as well as its incorporation into the food chain, starting by fish primarily inhabiting reef ecosystems and culminating in the intake of these by humans. Identifying the epidemiological link, its cardinal symptoms and a ected systems, such as gastrointestinal, the peripheral nervous system and, fortunately with a low frequency, the cardiovascular system, leads to a purely clinical diagnostic impression without necessitating further complementary studies; in addition, what would also help fight ciguatera poisoning is performing an adequate treatment of the symptoms right from the start, without underestimating or overlooking any associated complications.Ítem Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus(Multidisciplinary Digital Publishing Institute (MDPI), 2019) Navarro Quiroz, Elkin; Chavez-Estrada, Valeria; Macias-Ochoa, Karime; Ayala-Navarro, María Fernanda; Flores-Aguilar, Aniyensy Sarai; Morales-Navarrete, Francisco; De la Cruz Lopez, Fernando; Gomez Escorcia, Lorena; G. Musso, Carlos; Aroca Martinez, Gustavo; Gonzales Torres, Henry; Diaz Perez, Anderson; Cadena Bonfanti, Andres; Sarmiento Gutierrez, Joany; Meza, Jainy; Diaz Arroyo, Esperanza; Bello Lemus, Yesit; Ahmad, Mostapha; Navarro Quiroz, RobertoThe complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.Ítem From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID(MDPI, 2023) Gonzalez-Garcia, Pablo; Fiorillo Moreno, Ornella; Pacheco Lugo, Lisandro; Acosta Hoyos, Antonio; Villarreal Camacho, José Luis; Navarro Quiroz, Roberto; Pacheco Londoño, Leonardo; Aroca Martínez, Gustavo; Moares, Noelia; Gabucio, Antonio; Fernández-Ponce, Cecilia; Garcia-Cozar, Francisco; Navarro Quiroz, ElkinSevere Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers var-ious events from the molecular to the tissue level, which in turn is given by the intrinsic character-istics of each patient. Given the molecular diversity characteristic of each cellular phenotype, the possible cytopathic, tissue, and clinical effects are difficult to predict, which determines the hetero-geneity of COVID-19 symptoms. The purpose of this article is to provide a comprehensive review of the cytopathic effects of SARS-CoV-2 on various cell types, focusing on the development of COVID-19, which in turn may lead, in some patients, to the persistence of symptoms after recovery from the disease, a condition known as long COVID. We describe the molecular mechanisms un-derlying virus–host interactions, including alterations in protein expression, intracellular signaling pathways, and immune responses. In particular, the article highlights the potential impact of these cytopathies on cellular function and clinical outcomes, such as immune dysregulation, neuropsy-chiatric disorders, and organ damage. The article concludes by discussing future directions for re-search and implications for the management and treatment of COVID-19 and long COVID.Ítem Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus(Public Library of Science, 2019) Navarro Quiroz, Elkin; Navarro Quiroz, Roberto; Pacheco Lugo, Lisandro; Aroca Martínez, Gustavo; Gómez Escorcia, Lorena; Gonzalez Torres, Henry; Cadena Bonfanti, Andres; Marmolejo, Maria del Carmen; Sanchez, Eduardo; Villarreal Camacho, Jose Luis; Lorenzi, Hernan; Torres, Augusto; Navarro, Kelvin Fernando; Navarro Rodriguez, Pablo; Villa, Joe Luis; Fernández- Ponce, CeciliaThe aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone modifications in systemic lupus erythematosus (SLE). To identify miRNA dysregulation in SLE, we used miR2Disease and PhenomiR for information about miRNAs exhibiting differential regulation in disease and other biological processes, and HMDD for information about experimentally supported human miRNA–disease association data from genetics, epigenetics, circulating miRNAs, and miRNA–target interactions. This information was incorporated into the miRNA analysis. High-throughput sequencing revealed circulating miRNAs associated with kidney damage in patients with SLE. As the main finding of our in silico analysis of miRNAs differentially expressed in SLE and their interactions with disease-susceptibility genes, post-translational modifications, and transcription factors; we highlight 226 miRNAs associated with genes and processes. Moreover, we highlight that alterations of miRNAs such as hsa-miR-30a-5p, hsa-miR-16-5p, hsa-miR-142-5p, and hsa-miR-324-3p are most commonly associated with post-translational modifications. In addition, altered miRNAs that are most frequently associated with susceptibility-related genes are hsa-miR-16-5p, hsamiR- 374a-5p, hsa-miR-34a-5p, hsa-miR-31-5p, and hsa-miR-1-3p.Ítem The role of glycosyltransferases in colorectal cancer(MDPI, 2021) Fernández-Ponce, Cecilia; Geribaldi-Doldán, Noelia; Sánchez-Gomar, Ismael; Navarro Quiroz, Roberto; Atencio Ibarra, Linda; Gomez Escorcia, Lorena; Fernández-Cisnal, Ricardo; Aroca Martinez, Gustavo; García-Cózar, Francisco; Navarro Quiroz, ElkinColorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-translational modifications (PTMs) have been extensively studied in malignancies due to its relevance in tumor pathogenesis and therapy. This review is focused on the dysregulation of glycosyltransferase expression in CRC and its impact in cell function and in several biological pathways associated with CRC pathogenesis, prognosis and therapeutic approaches. Glycan structures act as interface molecules between cells and their environment and in several cases facilitate molecule function. CRC tissue shows alterations in glycan structures decorating molecules, such as annexin-1, mucins, heat shock protein 90 (Hsp90), β1 integrin, carcinoembryonic antigen (CEA), epidermal growth factor receptor (EGFR), insulin-like growth factor-binding protein 3 (IGFBP3), transforming growth factor beta (TGF-β) receptors, Fas (CD95), PD-L1, decorin, sorbin and SH3 domain-containing protein 1 (SORBS1), CD147 and glycosphingolipids. All of these are described as key molecules in oncogenesis and metastasis. Therefore, glycosylation in CRC can affect cell migration, cell–cell adhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemness regulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization and gut microbiota composition; all such functions are associated with the prognosis and evolution of the disease. According to these findings, multiple strategies have been evaluated to alter oligosaccharide processing and to modify glycoconjugate structures in order to control CRC progression and prevent metastasis. Additionally, immunotherapy approaches have contemplated the use of neoantigens, generated by altered glycosylation, as targets for tumor-specific T cells or engineered CAR (Chimeric antigen receptors) T cells.