Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus
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Fecha
2019
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Multidisciplinary Digital Publishing Institute (MDPI)
Resumen
The complex physiology of eukaryotic cells is regulated through numerous mechanisms,
including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these
mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity,
and their subcellular localization as well as modulation of the di erential expression of genes in
response to external and internal stimuli that allow an organism to respond or adapt to accordingly.
However, alterations in these mechanisms have been evidenced in several autoimmune diseases,
including systemic lupus erythematosus (SLE). The present review aims to provide an approach to
the current knowledge of the implications of these mechanisms in SLE pathophysiology.
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Palabras clave
Posttranslational modifications, Epigenetic mechanisms, Systemic lupus erythematosus, Ubiquitination, SUMOylation, Glycosylation, Hydroxylation, Phosphorylation, Sulfation, Acetylation