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Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus

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dc.contributor.authorNavarro Quiroz, Elkin
dc.contributor.authorChavez-Estrada, Valeria
dc.contributor.authorMacias-Ochoa, Karime
dc.contributor.authorAyala-Navarro, María Fernanda
dc.contributor.authorFlores-Aguilar, Aniyensy Sarai
dc.contributor.authorMorales-Navarrete, Francisco
dc.contributor.authorDe la Cruz Lopez, Fernando
dc.contributor.authorGomez Escorcia, Lorena
dc.contributor.authorG. Musso, Carlos
dc.contributor.authorAroca Martinez, Gustavo
dc.contributor.authorGonzales Torres, Henry
dc.contributor.authorDiaz Perez, Anderson
dc.contributor.authorCadena Bonfanti, Andres
dc.contributor.authorSarmiento Gutierrez, Joany
dc.contributor.authorMeza, Jainy
dc.contributor.authorDiaz Arroyo, Esperanza
dc.contributor.authorBello Lemus, Yesit
dc.contributor.authorAhmad, Mostapha
dc.contributor.authorNavarro Quiroz, Roberto
dc.date.accessioned2019-11-13T22:11:08Z
dc.date.available2019-11-13T22:11:08Z
dc.date.issued2019
dc.description.abstractThe complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.eng
dc.identifier.issn14220067
dc.identifier.urihttps://hdl.handle.net/20.500.12442/4335
dc.language.isoengeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)eng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceInternational Journal of Molecular Scienceseng
dc.sourceVol. 20, No. 22 (2019)spa
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dc.source.urihttps://doi.org/10.3390/ijms20225679spa
dc.subjectPosttranslational modificationseng
dc.subjectEpigenetic mechanismseng
dc.subjectSystemic lupus erythematosuseng
dc.subjectUbiquitinationeng
dc.subjectSUMOylationeng
dc.subjectGlycosylationeng
dc.subjectHydroxylationeng
dc.subjectPhosphorylationeng
dc.subjectSulfationeng
dc.subjectAcetylationeng
dc.titleEpigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosuseng
dc.typearticleeng

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