Repositorio :: Examinando por Autor "Bermudez, Valmore"

Examinando por Autor "Bermudez, Valmore"

Mostrando 1 - 10 de 10

Age-specific waist circumference cutoff-points for abdominal obesity diagnosis: a personalized strategy for a large Venezuelan population
(Springer, 2021) Bermudez, Valmore; Salazar, Juan; Martínez, María Sofía; Olivar, Luis Carlos; Nava, Manuel; Rojas, Milagros; Ortega, Ángel; Añez, Roberto; Toledo, Alexandra; Rojas, Joselyn; Chacín, Maricarmen; Rodríguez, Johel E.; D'Marco, Luis; Cano, Clímaco
Background Evidence shows that the ageing process is a determining factor in fat distribution, composition, and functionality. The goal of this research was to determine cut-off points for waist circumference according to age in the adult population from Maracaibo city, Venezuela. Methodology The Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with multi-stage randomized sampling. In this post-hoc analysis 1902 individuals ≥18 years and from both sexes were evaluated. Waist circumference ROC curves were built for each age group and sex, using metabolic phenotypes for classification. Results 52.2% (n = 992) were women, and the mean age was 38.7 ± 2. Cut-off points obtained for the <30 years age group were: 91 cm for women (Sensitivity: 96,8%, Specificity: 97,7%) and 94 cm for men (Sensitivity:100%, Specificity: 99,2%); for 30–49 years: women 94 cm (Sensitivity: 93.7%, Specificity: 97.1%) and men 95 cm (Sensitivity: 97.3%, Specificity: 100%); for ≥50 years: women 94 cm (Sensitivity: 91.8%, Specificity: 86.7%) and men 101 cm (Sensitivity: 100%, Specificity: 100%) Conclusion The use of specific cut-off points according to age groups is proposed to determine abdominal obesity in Maracaibo city due to the underestimation seen in young people and the overestimation observed in older people when using a unique cut-off point.
Association between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population [version 1; peer review: 2 approved, 1 approved with reservations]
(F1000 Research Ltda, 2019) Sánchez, María Patricia; Prieto, Carem; Mujica, Endrina; Vergara, Kendry; Valencia, Enifer; Villalobos, Eudymar; Medina, Mayerlim; Parra, Michael; D'Addosio, Rosanna; Hoedebecke, Kyle; Rodríguez, Johel E.; Bermudez, Valmore
Background: Adiponectin (ADIPOQ) is a hormone primarily synthesized by adipocytes and encoded by the ADIPOQ gene, which exerts anti-inflammatory, antiatheratogenic and insulin sensitizing functions. It has been shown that its plasma concentrations are decreased in individuals with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2), which could be due to variations in the gene coding for this protein. The aim of this study was to detect the +45 T>G polymorphism of the ADIPOQ gene in subjects with DM2 and MS in Maracaibo municipality, Zulia state, Venezuela. Methods: A total of 90 subjects who attended the Center for Metabolic Endocrine Research "Dr. Félix Gómez" were enrolled for this study, 46 of which had MS-DM2 and 44 of which were healthy control individuals. Genomic DNA was extracted from blood samples and PCR-restriction fragment length polymorphism analysis was carried out for the promoter region of the ADIPOQ gene. Likewise, the +45 T> G polymorphism was identified and correlated with MS and DM2 in the studied population. Results: The most frequent allele in both groups was the T allele, and the predominant genotype was homozygous T/T (79%). Genotypes with heterozygous T/G and G/G homozygous polymorphism were more frequent in the control group than in the MS-DM2 group. Regarding the individuals with T/G and G/G genotypes, statistically significant lower mean values were found for fasting glucose, total cholesterol, triacylglycerides, abdominal circumference, and for the medians of systolic and diastolic blood pressure. Odds ratio were calculated for the presence or absence of MS and DM2. Conclusions: The results suggested that the presence of the G allele exerts a protective effect on the carrier individuals, thus avoiding the appearance of the aforementioned metabolic alterations.
Attitudes of Medical Students Towards Psychiatry in Venezuela: a 6-Year Longitudinal Study
(Springer, 2021) Medina-Ortiz, Oscar; Pulido, Luis; Sanchez-Mora, Nora; Bermudez, Valmore; Pailhez, Guillem
Objective The authors evaluated changes in attitude towards psychiatry of medical students in one medical school in Venezuela. Methods Balon’s modified questionnaire was administered to first and sixth-year medical students to analyze their attitude towards psychiatry. The answers were compared with McNemar’s test. Results The students’ negative perception of psychiatry increased by the end of medical school with 45% of sixth-year students reportedly feeling uncomfortable when working with patients with psychiatric illness compared to only 8.3% of first-year medical students. Interest in specializing in psychiatry decreased from 2.6% in first-year medical students to 0% in sixth-year medical students (p=0.001). Conclusion Different factors may lead to the loss of interest in psychiatry of medical students in Venezuela, such as little time spent with patients, being in contact only with patients with psychosis, stigma about psychiatry among medical doctors and friends, feeling more comfortable with other specialties, and other specialties having a higher perceived status and being better paid.
Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela [version 1; referees: awaiting peer review]
(is published by F1000 Research Ltd, 2018-02) Bermudez, Valmore; Rojas, Joselyn; Salazar, Juan; Martinez, Maria Sofia; Olivar, Luis; Calvo, Maria Jose; Mindiola, Andres; Añez, Roberto; Wilches-Duran, Sandra; Cerda, Marcos; Graterol, Modesto; Graterol, Rosemily; Hernandez, Juan Diego; Garicano, Carlos; Velasco, Manuel
Background: In 1980, Reuben Andresen observed that in certain individuals, obesity did not increase mortality, introducing an atypical phenotype called “healthy obese”. Other studies reported that 10-15 % of lean individuals presented insulin resistance, hyperglycemia and dyslipidemia. The objective of this study was to evaluate biochemical and clinical characteristics of metabolic phenotypes in Maracaibo city. Methods: A descriptive, cross-sectional study with a randomized multistage sampling was performed including 1226 non diabetic individuals from both sexes. For phenotype definition, the subjects were first classified according to their BMI into Normal-Weight, Overweight and Obese; then divided in metabolically healthy and unhealthy using a two-step analysis cluster. To evaluate the relationship with coronary risk, a multiple logistic regression model was performed. Results: In the studied population, 5.2% (n=64) corresponded to unhealthy lean subjects, and 17.4% (n=217) to healthy obese subjects. Metabolically unhealthy normal-weight (MUNW) phenotype was found in males in 53.3% in contrast to 51.3% of metabolically unhealthy obese (MUO) phenotype found in females. An association between metabolically unhealthy phenotypes and a higher risk of a coronary event was found, especially for obese individuals (MHO: OR=1.85 CI95%: 1.11-3.09; p=0.02 and MUO: OR=2.09 CI95%: 1.34-3.28; p<0.01). Conclusion: Individuals with atypical metabolic phenotypes exist in Maracaibo city. Related factors may include insulin resistance, basal glucose levels, and triglycerides levels. Lastly, cardiovascular risk exhibited by healthy obese individuals should be classified in categories of major coronary risk related to lean subjects.
Cigarette smoking and metabolic syndrome components: a cross-sectional study from Maracaibo City, Venezuela [version 1; referees: 1 approved with reservations]
(F1000 Research Ltda, 2018-05-22) Bermudez, Valmore; Olivar, Luis Carlos; Torres, Wheeler; Navarro, Carla; Gonzalez, Robys; Morocho, Alicia; Mindiola, Andres; Chacin, Maricarmen; Arias, Victor; Añez, Roberto; Salazar, Juan; Riaño Garzon, Manuel; Diaz Camargo, Edgar; Judith Bautista, Maria; Rojas, Joselyn
Background: A growing body of evidence suggests that cigarette smoking can cause the onset of metabolic syndrome prior to cardiovascular diseases. Therefore, the objective of this study was to evaluate the relationship between smoking habit and metabolic syndrome components in an adult population from Maracaibo city, Venezuela. Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multi-stage sampling. In this sub-study, 2212 adults from both genders were selected. On the basis of their medical background, they were classified as smokers, non-smokers and former smokers. Metabolic syndrome was defined according to Harmonizing 2009 criteria, using population-specific abdominal circumference cut-off points. The association between risk factors was evaluated using a logistic regression model. Results: In the studied population, 14.8% were smokers, 15.4% were former smokers. In the multivariate analysis, the presence of metabolic syndrome (smokers: OR, 1.54; 95% CI, 1.11–2.14; p=0.010) and its components were related to cigarette smoking, with the exception of hyperglycemia. High blood pressure was inversely associated with current smoking status (smokers: OR, 0.70 (0.51–0.95); p=0.025).
Comparación de índices antropométricos para agregación de múltiples factores de riesgo en adultos de Cuenca, Ecuador
(Instituto Nacional de Salud, 2018) Torres, Maritza; Ortiz, Rina; Sigüencia, Wilson; Ordoñez, Maria; Alcántara, Víctor; Salazar, Juan; Añez, Roberto; Rojas, Joselyn; Bermudez, Valmore
Objetivos. El objetivo de este estudio es comparar la capacidad predictiva de diferentes índices antropométricos en la determinación de la agregación de múltiples factores de riesgo (AMFR) en la población adulta de la ciudad de Cuenca, Ecuador. Materiales y métodos. Se realizó un estudio descriptivo transversal con un muestreo aleatorio multietápico en 318 sujetos adultos a quienes se les realizó una evaluación clínica, antropométrica y de laboratorio; siendo la circunferencia abdominal, índice de masa corporal (IMC) e índice cintura altura (ICA) los índices evaluados. La AMFR se definió como la presencia de ≥ dos componentes del síndrome metabólico (excluyendo circunferencia abdominal). Se realizaron curvas COR para determinar el área bajo la curva (ABC) para cada índice. Resultados. De los 318 individuos, un 54,1% (n=172) presentaron AMFR. Según los resultados obtenidos por curvas COR, la mayor capacidad predictiva en mujeres se observó con el IMC y el ICA (ABC: 0,751 y 0,750, respectivamente) mientras que en hombres la circunferencia abdominal y el ICA mostraron una capacidad predictiva similar (ABC=0,762). El análisis multivariante ajustado por sexo y edad mostró que el ICA elevado (OR: 2,53; IC95%: 1,12-5,71; p=0,026) fue el mejor predictor de AMFR, seguido por el IMC (OR: 2,15; IC95%: 1,19-3,88; p=0,010). Conclusiones. La capacidad predictiva de los índices antropométricos está influenciada por el sexo, no obstante, el ICA es el mejor predictor de la AMFR en la población de Cuenca.
Data Mining and Endocrine Diseases: A New Way to Classify?
(Elsevier, 2018-04) Salazar, Juan; Espinoza, Cristobal; Mindiola, Andres; Bermudez, Valmore
Data mining consists of using large database analysis to detect patterns, relationships and models in order to describe (or even predict) the appearance of a future event; to accomplish this, it uses classification methods, rules of association, regression patterns, link and cluster analyses. Recently this approach has been used to propose a new diabetes mellitus classification, using information analysis techniques through which the selection bias minimally influences categorization, this new focus that includes data mining previously implemented to predict, identify biomarkers, complications, therapies, health policies, genetic and environmental effects of this disease; it could be generalized in the field of endocrinology, in the classification of other endocrine diseases.
Estigma percibido y calidad de vida relacionada con la salud en pacientes con diagnóstico de epilepsia en La Guajira
(Ediciones Universidad Simón Bolívar, 2023) Bravo Guzmán, Diana Judith; Zambrano León, José Antonio; García Puello, Floralinda; Bermudez, Valmore
Debido a la complejidad y curso crónico de la epilepsia, las personas con esta enfermedad se enfrentan a varios factores de carga social y psicológica que pueden ser generados por el estigma percibido, impactando en la calidad de vida relacionada con la salud mediante la discriminación y la autopercepción negativa. Objetivo: Analizar la relación entre el estigma percibido y el compromiso de la calidad de vida relacionada con la salud en pacientes con diagnóstico de epilepsia en el departamento de la Guajira. Metodología: Estudio cuantitativo, descriptivo transversal con fase analítica correlacional, constituido por 135 pacientes con diagnóstico de epilepsia de la Fundación Vida Con Amor IPS, en La Guajira Colombia. Resultados: El 50.4% fueron hombres; media de edad de 43 años y media de presentación de crisis epilépticas 24,8 años (DE:18,8), 59% presentaron estigma leve- moderado (p=0.8), 53% regular calidad de vida, relación 1:1 con el sexo (p=0.8). Existe correlación moderada entre el compromiso de la calidad de vida y el estigma percibido por la población de estudio (p<0,000). Conclusiones: Gran parte de la población se siente estigmatizada y más de la mitad tiene algún grado de compromiso en su calidad de vida relacionada con la salud, las variables clínicas que presentaron relación con dicha variable fueron: privación de sueño, cambios en la temperatura, etiología de la epilepsia y número de fármacos anticrisis, las situaciones estresantes fue la única que se relacionó con la calidad de vida y el estigma percibido.
Neurofeedback effects on cognitive performance in children with attention deficit
(Sociedad Venezolana de Farmacología Clínica y Terapéutica, 2018) Riaño-Garzón, Manuel E.; Díaz-Camargo, Edgar Alexis; Torrado-Rodríguez, Javier Leonardo; Uribe-Alvarado, J. Isaac; Contreras-Velásquez, Julio C.; Fierro-Zarate, Carmen Alexandra; Salazar, Juan; Bermudez, Valmore
The objective of this research was to analyze the effects of an intervention program through neurofeedback, on the cognitive performance in children with inattention indicators. A quasi-experimental pretest-posttest study was used under a positivist epistemology, with a comparative analysis for each evaluated cognitive process. A sample of 29 cases was intentionally selected from a group of children and young adolescents with low performance indicators from a Therapeutic Center from Cucuta-Colombia. The neurofeedback program was developed in 20 sessions with the purpose of increase low-beta waves (12-16 Hz) and inhibition theta waves (4-7 Hz). A comparative statistically analysis with five months of difference was carried out using Wilcoxon test, finding significant differences between the pretest and the posttest in neuropsychological tests of auditory-visual attention, encoding memory and planning. The results are discussed with empirical backgrounds that have shown positive effects in this type of interventions.
Relación entre los niveles de sobrecarga, ansiedad, depresión y los dominios de la calidad de vida en cuidadores primarios de pacientes con accidente cerebro vascular en dos instituciones prestadoras de servicios de salud de la ciudad de Barranquilla. Enero 2023 a Marzo de 2024
(Ediciones Universidad Simón Bolívar, 2024) Gallo Urina, Samir; Pulgar González, Melissa Paola; García Puello, Floralinda; Bermudez, Valmore; Vargas Manotas, José
Objetivo: Determinar la relación existente entre los niveles de sobrecarga, ansiedad, depresión y los dominios de calidad de vida en cuidadores primarios de pacientes con Accidente Cerebro Vascular. Metodología: muestra de 193 cuidadores primarios, seleccionados a través de muestreo no probabilístico. Los participantes fueron evaluados mediante cuestionarios validados: la escala WHOQOL-BREF para calidad de vida, GAD-7 para ansiedad, PHQ-9 para depresión, y la escala abreviada de Zarit para sobrecarga. Se utilizaron medidas descriptivas y la correlación de Spearman para evaluar la relación entre las variables principales del estudio (sobrecarga, ansiedad, depresión y los dominios de la calidad de vida), nivel de significancia estadística de p< 0,05. Resultados: Los resultados mostraron que el 27.2% de los cuidadores experimentan una sobrecarga intensa, mientras que el 30.4% presentaba ansiedad leve y el 14.1% sufría de depresión grave. En cuanto a la calidad de vida, el dominio físico se encontraba afectado en un 24.6% de los cuidadores, mientras que el dominio psicológico presentaba un deterioro significativo en el 18.8% de la muestra. Las correlaciones de Spearman indicaron una relación negativa significativa entre la sobrecarga y la calidad de vida en sus dominios físico, psicológico, social y del entorno. Conclusiones: se encontró que los cuidadores primarios de pacientes con ACV experimentan altos niveles de sobrecarga, ansiedad y depresión, los cuales impactan de manera negativa en su calidad de vida. Estos hallazgos subrayan la importancia de diseñar intervenciones orientadas a reducir la carga emocional y física de los cuidadores para mejorar tanto su bienestar como el de los pacientes.

Examinando por Autor "Bermudez, Valmore"

Resultados por página

Opciones de ordenación