Examinando por Autor "Aroca, Gustavo"
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Ítem Anxiety and Depression in Patients Hospitalized With Chronic Kidney Disease in Barranquilla Clinics, Colombia(Canadian Center of Science and Education, 2018-10) Sierra Llamas, Carmen A.; Donado Castillo, Rafael E.; Aroca, Gustavo; Depine, Santos Ángel; Gaviria, Gladys; Martínez, ÁlvaroThe purpose of this study is to determine the levels of anxiety and depression in patients aged between 18 and 70 years, hospitalized with chronic kidney disease in a clinic entity of the city of Barranquilla. The type of research is descriptive, presenting the information through the indicators and statistical tables, the Hospital Scale of Anxiety and Depression of, Zigmond & Smith (1983), which evaluates the detection of depressive and anxious disorders in the non-psychiatric hospital context. The application of the Scale was performed in the hospital entity of the city of Barranquilla to 50 patients with Chronic Kidney Disease. The results they are beneficial in the short term, because they create new research proposals applied to another population group diagnosed with chronic diseases, especially for the evaluation and intervention in the area of health psychology. In the long term, new theories, methods of intervention and evaluation applied to the population of patients with chronic kidney disease will be studied. In the same way, the results show marked trends related to depression, an aspect that is consistent with the deterioration that affects the individual in the course of the disease and also show a positive correlation of the study variables, depression and anxiety disorders in patients with CKD can be due to a symptomatology or consequence of psychological burnout.Ítem Asociación de variantes polimórficas de los sistemas PTPN22, TNF y VDR en niños con nefritis lúpica: un estudio en tríos de familias colombianas(Instituto Nacional de Salud, 2017) Garavito, Gloria; Egea, Eduardo; Fang, Luis; Malagón, Clara; Olmos, Carlos; González, Luz; Guarnizo, Pilar; Aroca, Gustavo; López, Guillermo; Iglesias, AntonioIntroducción. El lupus eritematoso sistémico es una enfermedad autoinmune cuya gravedad varía según la raza, género y edad de aparición. Esta disparidad también se observa en los marcadores genéticos asociados con la enfermedad presentes en los genes PTPN22, VDR y TNF. La estratificación genética que presentan las diferentes poblaciones en el mundo puede estar influyendo dicha variabilidad. Objetivo. Analizar la asociación y heredabilidad de variantes genéticas de los genes PTPN22, VDR y TNF con nefritis lúpica pediátrica (NLp) en familias colombianas. Materiales y métodos. Se realizó un estudio basado en familias con 46 tríos (caso/padre y madre). Se genotipificaron las variantes rs2476601 de PTPN22; rs361525 y rs1800629 de TNF; TaqI [rs731236], ApaI [rs7975232], BsmI [rs1544410] y FokI [rs2228570] de VDR mediante qPCR. Se estimó el efecto de la sobretransmisión del alelo de riesgo de padres a hijos y el desequilibrio de ligamiento de los loci VDR y TNF. Resultados. Se observó que el alelo A de rs2476601 en PTPN22 se distribuyó en el 8,69 % [n=16] de los padres mientras que en los casos es de 19,5 % [n=18] al igual que es sobretransmitido de padres a hijos 17 veces más con relación al alelo G (p=0,028). Los polimorfismos de TNF y VDR no se mostraron en desequilibrio de transmisión. Las variantes TaqI, ApaI y BsmI del VDR se mostraron en desequilibrio de ligamiento. Conclusión. Estos hallazgos muestran una asociación del polimorfismo rs2476601 de PTPN22 con NLp debido a su sobretransmisión en el grupo de familias estudiadas.Ítem Association of FokI polymorphism of the VDR genewith systemic lupus erythematosus in anadolescent population of the Colombian Caribbean(Elsevier, 2023) Garavito, Gloria; Fang, Luis; Domínguez-Vargas, Alex; Moreno-Woo, Ana; López-Luch, Guillermo; Iglesias, Antonio; Aroca, Gustavo; Egea, EduardoVitamin D and vitamin D receptor (VDR) polymorphisms are associated withautoimmune diseases including systemic lupus erythematosus (SLE). The aim of this studyis to assess the genetic association between VDR polymorphisms: TaqI, ApaI, Bsml and FokIand SLE with serum levels of Vitamin D in the Colombian Caribbean population.Method: Case and control study. One hundred and thirty-three patients with SLE and 100healthy individuals were included. VDR polymorphism were genotyped by RT-PCR andTaqman®probes. Allelic, genotypic and haplotype associations were estimated. Serum vita-min D concentrations were quantified by Elisa. Values of 30 to 100 ng/ml were establishedas a normal reference range. P values <.05 were considered statistically significant.Results: A high prevalence of SLE was observed in women (94%) and was associated witha higher risk of SLE [OR: 10.8; 95% CI: 4.7–24.6] (p < .05). Moreover, higher risk of SLE wasobserved in individuals with FokI VDR [rs2228570] [OR: 1.58; 95% CI: 1.05−2.36] in allelic mod-els. The ACCA Haplotype of TaqI/ApaI/Bsml/FokI polymorphisms was associated with higherrisk of SLE [OR = 2.28, 95% CI = 1.12−4.66, psim <.01]. Vitamin D deficiency was evidenced in11.3% of the patients.Ítem Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community: In search of shared genetic markers(Elsevier, 2024) Garavito-De Egea, Gloria; Domínguez-Vargas, Alex; Vélez, Jorge I.; Aroca, Gustavo; Fang, Luis; Navarro-Quiroz, Elkin; Espitaleta, Zilac; Del Toro-Camargo, Kenny; Martínez-Ariza, Leticia; González-Vargas, Tatiana; García, Susana; Arcos-Burgos, MauricioIn summary, our study outlines oligogenic common variation underpinning the susceptibility to develop T1D. These genetic polymorphisms are also shared by patients suffering from other diseases such as LN and JIA, indicating that the shared genetic architecture defined by pleiotropy and epistasis shapes the genetic susceptibility of these disorders in this multiethnic population. Given the predicted functional nature of these genetic variants, it is very likely that in this understudied multiethnic population, genes harboring these mutations are major contributors to AID immunopathology and provide new insights into the autoimmune tautology in this group of diseases.Ítem COVID-19 en pacientes en hemodiálisis en Colombia: reporte de 7 casos(Instituto Nacional de Salud, 2020) Aroca, Gustavo; Vélez-Verbel, María; Cadena, Andrés; Avendaño, Lil Geraldine; Hernández, Sandra; Sierra, Angélica; Cabarcas, Omar; Santos Ángel, Santos ÁngelA finales del año 2019, en Wuhan, China, se inició el brote de un nuevo coronavirus el cual se dispersó por todo el mundo, infectando y cobrando miles de vidas. A la fecha se conocen ciertas comorbilidades que se consideran factores de riesgo para desenlaces poco satisfactorios de la enfermedad, sin embargo, es poco lo que se ha descrito con respecto a pacientes en hemodiálisis, a pesar de tratarse de una población de alto riesgo de infección, complicaciones y muerte. En este artículo se describe el curso clínico durante la enfermedad COVID-19 en 7 pacientes en hemodiálisis permanente, y se describen las manifestaciones clínicas y complicaciones. Se realizan recomendaciones para realizar manejo en pacientes con enfermedad renal crónica.Ítem Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course(Public Library of Science, 2022) Lombardi, Raúl; Ferreiro, Alejandro; Ponce, Daniela; Claure-Del Granado, Rolando; Aroca, Gustavo; Venegas, Yanissa; Pereira, Mariana; Chavez-Iñiguez, Jonathan; Rojas, Nelson; Villa, Ana; Colombo, Marcos; Carlino, Cristina; Guimaraes, Caio; Younes-Ibrahim, Mauricio; Rizo, Lilia Maria; Guzmán, Gisselle; Varela, Carlos; Rosa-Diez, Guillermo; Janiques, Diego; Ayala, Roger; Coronel, Galo; Roessler, Eric; Amor, Serena; Osorio, Washington; Rivas, Natalia; Pereira, Benedito; de Azevedo, Caroline; Flores, Adriana; Ubillo, José; Raño, Julieta; Yu, Luis; Burdmann, Emmanuel A.; Rodríguez, Luis; Galagarza-Gutiérrez, Gianny; Curitomay-Cruz, JesúsThe Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54–74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.Ítem Low performance of sinovac vaccine particularly with belatacept therapy in a study with different types of COVID-19 vaccines in transplanted patients(Elsevier, 2023) Arias-Murillo, Jazmín Roció; Salinas-Nova, María Angélica; Caicedo, Tatiana; Galindo-Borda, Marisol; Meneses-Gil, Ximena; Montero, Camilo; Girón, Fernando; Pedraza, Nestor; Aroca, Gustavo; Ospina-Martínez, Martha Lucía; Mercado-Reyes, MarcelaThe huge impact of SARS-CoV-2 infections on organ transplant recipients makes it necessary to optimize vaccine efficacy in this population. To effectively implement multiple strategies, it is crucial to understand the performance of each type of available vaccine. In our study, the antibody titer was measured, and the presence of antibodies against SARS-CoV-2 was evaluated after 90 days of immunization; furthermore, the differences between hybrid immunity, immunity by vaccination, and immunosuppressant type were identified. As a result, of the patients included in this study (n = 160), 53% showed antibodies against SARS-CoV-2 90 days after the first dose in patients who had completed the vaccination schedule. Antibody titers were higher in patients with hybrid immunity, and the proportion of nonresponsive patients was higher among those who received the immunosuppressant belatacept in their post-transplant regimen (P = .01). Only 15% of patients treated with this medicine seroconverted and patients vaccinated with Corona- Vac and treated with belatacept showed no response. In conclusion, a reduced response to vaccines against SARS-CoV-2 was identified in the transplant population, and this response varied with the type of vaccine administered and the immunosuppressive treatment.Ítem May measurement month 2018: an analysis of blood pressure screening results from Colombia(European Society of Cardiology, 2020) Lopez-Jaramillo, Patricio; Otero, Johanna; Alvernia, Juliana; Ney-Salazar, Daniela; Lopez-Lopez, Jose; Accini, Jose L.; Aroca, Gustavo; Urina-Triana, Miguel; Sánchez-Vallejo, Gregorio; Arcos, Edgar; Casanova, María E.; García, Henry; Beaney, Thomas; Chis Ster, Anca; Poulter, Neil R.High blood pressure (BP) is the leading global preventable cause of death and the most common risk factor for cardiovascular disease (CVD). However, due to its asymptomatic nature, the lack of awareness of this condition causes underdiagnosis and low rates of adherence to pharmacological treatment. Looking for practical approaches to increase awareness worldwide, the International Society of Hypertension (ISH) implemented the 2nd May Measurement Month campaign in 2018 (MMM18). In order to contribute to this initiative, Colombia participated as one of the 89 countries involved in this hypertension screening programme. Blood pressure was measured in subjects from 11 departments in Colombia. Under the leadership of the Fundacio´n Oftalmolo´gica de Santander (FOSCAL), 400 volunteers across the country collected the data following the MMM protocol. Measurements from 35 548 participants with a mean age of 41.9 years were obtained. In total, 9475 (26.7%) of the total population studied had hypertension. Of those with hypertension, 69.9% of these subjects were aware of their condition, 65.0% were on antihypertensive medication, and 43.1% had controlled BP. Of those on medication, 66.3% had controlled BP. Hypertension screening, awareness, treatment, and control should be a priority in public health objectives due to its elevated burden of disease and direct association with increased CVD. The MMM campaign provided a positive impact in the diagnosis of hypertension across Colombia. Although efforts are being made to expand treatment capability and adherence, still more are needed to insure a broader coverage of antihypertensive medication in Colombia.Ítem May Measurement Month 2022: results from the global blood pressure screening campaign(BMJ, 2024) Beaney, Thomas; Keziah Kerr, Gabriele; Kiru, Gaia ; McArdle, Harsha; Schlaich, Markus; Schutte, Aletta E.; Stergiou, George S.; Ji-guang, Wang; Marin, Marcos J.; Henandez-Hernandez, Rafael; F. Diaz, Alejandro Bimbo; Alcocer, Luis; Lopez-Jaramillo, Patricio; Poulter, Neil; Lopez-Lopez, José P.; Otero, Odont Johanna; Zulma, Urbina; Sanchez-Vallejo, Gregorio; Narváez, Claudia; Camacho, Paul A.; Urina-Triana, Miguel; Quintero, Adalberto; Aroca, Gustavo; Campos, Alfonso; Arcos, Edgar; Pérez-Mayorga, Maritza; Mosquera, Walter; García-Ortiz, Luis H.Introduction Elevated blood pressure (BP) is the major contributor to mortality and disease burden worldwide. May Measurement Month (MMM) is a global BP screening campaign, which aims to raise awareness of BP measurement and provide evidence to inform and influence related health policy. Methods This cross-sectional survey included individuals aged≥18 years recruited through opportunistic sampling at sites in 60 countries during MMM 2022. Each participant had three sitting BP measurements and a questionnaire was completed including demographics, comorbidities and lifestyle factors. Hypertension was defined as a systolic BP≥140 mm Hg and/or a diastolic BP≥90 mm Hg (average of the second and third readings) or taking antihypertensive medication. Multiple imputation was used to estimate BP readings where any participant’s BP readings were missing. Linear mixed effects models were used to identify associations between participant characteristics and systolic or diastolic BP. Results Of the 715 518 participants surveyed (excluding 50 200 self-measured home BP screenees recruited via the ZOE Health Study app), 257 421 (36.0%) were identified as hypertensive, of whom 57.6% were aware and 49.3% were on antihypertensive medication. Of all participants with hypertension, 26.1% were controlled to <140/90 mm Hg and 12.0% to <130/80 mm Hg. Of those taking antihypertensive medication, 52.7% were taking only one drug class, 52.9% were controlled to <140/90 mm Hg and 24.4% to 130/80 mm Hg. In total, 190 314 (26.6% of total surveyed, 73.9% of hypertensives) participants screened were found to have untreated or inadequately treated hypertension. Only 27.6% of treated hypertensive participants were taking a statin. Substantial coexistence of diabetes, overweight and hypertension was apparent among participants.Ítem Molecular Mechanisms of Diabetic Kidney Disease(MDPI, 2022) Rico-Fontalvo, Jorge; Aroca, Gustavo; Cabrales, José; Daza-Arnedo, Rodrigo; Yánez-Rodríguez, Tomas; Martínez-Ávila, María Cristina; Uparella-Gulfo, Isabella; Raad-Sarabia, MaríaThe inflammatory component of diabetic kidney disease has become of great interest in recent years, with genetic and epigenetic variants playing a fundamental role in the initiation and progression of the disease. Cells of the innate immune system play a major role in the pathogenesis of diabetic kidney disease, with a lesser contribution from the adaptive immune cells. Other components such as the complement system also play a role, as well as specific cytokines and chemokines. The inflammatory component of diabetic kidney disease is of great interest and is an active research field, with the hope to find potential innovative therapeutic targets.Ítem Prevalence of proteinuria, hypertension, and diabetes in an indigenous population of the biodiverse jungle of the Colombian pacific coast(International Society of Nephrology (ISN), 2025) Ramírez Marmolejo, Roberto; Ramírez Isaza, Sofia; Isaza Echeverri, Lina Maria; Hernán Mejía, Carlos; Elcy Rojas, Myrian; Aroca, GustavoIntroduction: In Colombia, South America, in 2018, 1,905,617 people identified themselves as indigenous. Recognizing 115 ethnic groups We visited the Chonara Huena and Ipua Euja communities, in the jungle area of the Pacific coast. (See image#1) This study aimed to determine the prevalence of Hypertension, Diabetes, Proteinuria, Obesity, and poor nutrition(See images#2,3) Methods: It was developed by a direct visit to the population, where a sampling was made with people who voluntarily accepted to participate in capillary glucose, spontaneous albuminuria, blood pressure, and anthropometry, recording information in a survey. This is a descriptive cross-sectional prevalence study. With consent for the publication of data and images, with the approval of the ethics committee of the Simón Bolívar University of Barranquilla Results: The Colombian Pacific rainforest region has an area of 83,170 km2 which corresponds to about 7% of the territory. It is the second most tropical biodiverse region in the worldÍtem Refractory nephrotic syndrome in focal and segmental glomerulosclerosis by pmm2 genetic variant(International Society of Nephrology (ISN), 2025) Dulce M., Jaime Arturo; Conde, Juan; Aroca, GustavoIntroduction: Nephrotic syndrome (NS) is a clinical condition charac terized by massive proteinuria, edema, hypoalbuminemia, and hyper lipidemia. The etiology may be secondary to systemic, metabolic, infectious, neoplastic, and pharmacological diseases. There is a group of primary causes of unknown etiology whose pathophysiological mech anism is immunological whose most frequent histological pattern in adults is focal segmental glomerulosclerosis (FSGS), minimal change disease and membranous nephropathy that represent podocithopathies. Currently, the KDIGO guidelines add that FSGS may have a genetic etiology, which merits a different diagnostic and therapeutic approach due to its refractoriness to immunosuppressive management, deter mining the causative gene is of great importance to predict its relapse in transplantation. A diversity of genes contributing to podocitopathies (NEPH1, TRPC6, CRB2, FAT1) located in the diaphragm slit has been highlighted, but very few cases have been reported with the PMM2 genetic variant.