Low performance of sinovac vaccine particularly with belatacept therapy in a study with different types of COVID-19 vaccines in transplanted patients

Cargando...
Miniatura

Fecha

2023

Autores

Arias-Murillo, Jazmín Roció
Salinas-Nova, María Angélica
Caicedo, Tatiana
Galindo-Borda, Marisol
Meneses-Gil, Ximena
Montero, Camilo
Girón, Fernando
Pedraza, Nestor
Aroca, Gustavo
Ospina-Martínez, Martha Lucía

Título de la revista

ISSN de la revista

Título del volumen

Editor

Elsevier

Resumen

The huge impact of SARS-CoV-2 infections on organ transplant recipients makes it necessary to optimize vaccine efficacy in this population. To effectively implement multiple strategies, it is crucial to understand the performance of each type of available vaccine. In our study, the antibody titer was measured, and the presence of antibodies against SARS-CoV-2 was evaluated after 90 days of immunization; furthermore, the differences between hybrid immunity, immunity by vaccination, and immunosuppressant type were identified. As a result, of the patients included in this study (n = 160), 53% showed antibodies against SARS-CoV-2 90 days after the first dose in patients who had completed the vaccination schedule. Antibody titers were higher in patients with hybrid immunity, and the proportion of nonresponsive patients was higher among those who received the immunosuppressant belatacept in their post-transplant regimen (P = .01). Only 15% of patients treated with this medicine seroconverted and patients vaccinated with Corona- Vac and treated with belatacept showed no response. In conclusion, a reduced response to vaccines against SARS-CoV-2 was identified in the transplant population, and this response varied with the type of vaccine administered and the immunosuppressive treatment.

Descripción

Palabras clave

Citación

This research was funded by the National Institute of Health, project code CEMIN-19-2021, an investment project strengthening the coordination of blood banks and donation and transplant networks, national code BPIN-2018011000083, and resources of the hospitals with transplant programs participating.

Colecciones