Molecular Mechanisms of Diabetic Kidney Disease
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Fecha
2022
Autores
Rico-Fontalvo, Jorge
Aroca, Gustavo
Cabrales, José
Daza-Arnedo, Rodrigo
Yánez-Rodríguez, Tomas
Martínez-Ávila, María Cristina
Uparella-Gulfo, Isabella
Raad-Sarabia, María
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MDPI
Resumen
The inflammatory component of diabetic kidney disease has become of great interest in
recent years, with genetic and epigenetic variants playing a fundamental role in the initiation and
progression of the disease. Cells of the innate immune system play a major role in the pathogenesis of
diabetic kidney disease, with a lesser contribution from the adaptive immune cells. Other components
such as the complement system also play a role, as well as specific cytokines and chemokines. The
inflammatory component of diabetic kidney disease is of great interest and is an active research field,
with the hope to find potential innovative therapeutic targets.
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Palabras clave
Genetics, Epigenetic, Inflammatory, Innate, Adaptive, Cytokines, Innovation
