Molecular Mechanisms of Diabetic Kidney Disease

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Fecha

2022

Autores

Rico-Fontalvo, Jorge
Aroca, Gustavo
Cabrales, José
Daza-Arnedo, Rodrigo
Yánez-Rodríguez, Tomas
Martínez-Ávila, María Cristina
Uparella-Gulfo, Isabella
Raad-Sarabia, María

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MDPI

Resumen

The inflammatory component of diabetic kidney disease has become of great interest in recent years, with genetic and epigenetic variants playing a fundamental role in the initiation and progression of the disease. Cells of the innate immune system play a major role in the pathogenesis of diabetic kidney disease, with a lesser contribution from the adaptive immune cells. Other components such as the complement system also play a role, as well as specific cytokines and chemokines. The inflammatory component of diabetic kidney disease is of great interest and is an active research field, with the hope to find potential innovative therapeutic targets.

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Genetics, Epigenetic, Inflammatory, Innate, Adaptive, Cytokines, Innovation

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