Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria

D’Marco, Luis; Guerra-Torres, Xavier; Viejo, Iris; Lopez-Romero, Luis; Yugueros, Alejandra; Bermúdez, Valmore

Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria

Archivos

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Fecha

2022

Autores

D’Marco, Luis

Guerra-Torres, Xavier

Viejo, Iris

Lopez-Romero, Luis

Yugueros, Alejandra

Bermúdez, Valmore

Editor

Touch Medical Media

Resumen

Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage kidney disease worldwide. Its pathogenic mechanism is complex, and it can affect the entire structures of the kidneys such as the glomerulus, tubules and interstitium. Currently, the urinary albumin excretion rate and the estimated glomerular filtration rate are widely accepted as diagnostic criteria. However, some studies have reported a different or non-classical clinical course of DKD, with some patients showing declined kidney function with normal levels of albuminuria, known as the ‘non-albuminuric DKD’ phenotype. The pathogenesis of this phenotype remains unclear, but some clinical and pathological features have been postulated. This review explores the evidence regarding this topic.