Correlaciones clínicas de los niveles de lactato sérico en pacientes con preeclampsia con síntomas graves
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Fecha
2024
Autores
Díaz-Pérez, Anderson
Redondo Cantillo, Tatiana Marcela
Córdoba Ramos, Sixta Mileydi
Franco Novella, Hernando
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Academia Nacional de Medicina
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
Objetivo: Analizar las correlaciones entre los niveles
de lactato sérico y varios parámetros clínicos en
pacientes con preeclampsia con síntomas graves.
Metodología: Estudio observacional, analítico,
transversal y retrospectivo. Se incluyó una muestra
de 100 pacientes diagnosticados con preeclampsia
con síntomas graves, admitidos en la unidad de
cuidados intensivos obstétricos de un hospital terciario
durante un período de 12 meses. Los datos clínicos
y paraclínicos se obtuvieron mediante la revisión
de historias clínicas electrónicas. Las variables
recolectadas incluyeron edad gestacional, presión
arterial, niveles de plaquetas, LDH, PTT, PT, INR,
fibrinógeno y lactato sérico. Se realizaron análisis
descriptivos, correlación de Pearson y regresión
logística. Resultado: Los niveles elevados de
lactato sérico se correlacionaron positivamente
con el potasio, leucocitos, edad gestacional, INR y
PaCO2, y negativamente con el hematocrito, PaO2,
sodio y bicarbonato. La regresión logística indicó
que el lactato elevado estaba significativamente
asociado con un mayor riesgo de disfunción orgánica
y síndrome HELLP. Conclusión: Los niveles de
lactato sérico constituyen un biomarcador relevante
para la evaluación de pacientes con preeclampsia
con síntomas graves, asociados con un mayor riesgo
de complicaciones graves. Estos hallazgos subrayan
la importancia del monitoreo continuo del lactato
sérico para mejorar el manejo clínico y los resultados
en pacientes con preeclampsia con síntomas graves.
Es crucial realizar investigaciones adicionales para
validar estos hallazgos y desarrollar protocolos
clínicos basados en evidencia.
Objective: To analyze correlations between serum lactate levels and various clinical parameters in patients with severe preeclampsia. Methodology: Observational, analytical, cross-sectional, and retrospective study. A sample of 100 patients diagnosed with preeclampsia with severe symptoms, admitted to the obstetric intensive care unit of a tertiary hospital for 12 months, was included. Clinical and paraclinical data were obtained by reviewing electronic medical records. The variables collected included gestationalage, blood pressure, platelet levels, LDH, PTT, PT, INR, fibrinogen, and serum lactate. Descriptive analyses, Pearson correlation, and logistic regression were performed. Results: Elevated serum lactate levels were positively correlated with potassium, leukocytes, gestational age, INR, and PaCO2 and negatively correlated with hematocrit, PaO2, sodium, and bicarbonate. Logistic regression indicated that elevated lactate was significantly associated with an increased risk of organ dysfunction and HELLP syndrome. Conclusion: Serum lactate levels are a relevant biomarker for the evaluation of patients with preeclampsia with severe symptoms associated with an increased risk of serious complications. These findings underscore the importance of continuous serum lactate monitoring to improve clinical management and outcomes in patients with preeclampsia with severe symptoms. Further research is crucial to validate these findings and develop evidence-based clinical protocols.
Objective: To analyze correlations between serum lactate levels and various clinical parameters in patients with severe preeclampsia. Methodology: Observational, analytical, cross-sectional, and retrospective study. A sample of 100 patients diagnosed with preeclampsia with severe symptoms, admitted to the obstetric intensive care unit of a tertiary hospital for 12 months, was included. Clinical and paraclinical data were obtained by reviewing electronic medical records. The variables collected included gestationalage, blood pressure, platelet levels, LDH, PTT, PT, INR, fibrinogen, and serum lactate. Descriptive analyses, Pearson correlation, and logistic regression were performed. Results: Elevated serum lactate levels were positively correlated with potassium, leukocytes, gestational age, INR, and PaCO2 and negatively correlated with hematocrit, PaO2, sodium, and bicarbonate. Logistic regression indicated that elevated lactate was significantly associated with an increased risk of organ dysfunction and HELLP syndrome. Conclusion: Serum lactate levels are a relevant biomarker for the evaluation of patients with preeclampsia with severe symptoms associated with an increased risk of serious complications. These findings underscore the importance of continuous serum lactate monitoring to improve clinical management and outcomes in patients with preeclampsia with severe symptoms. Further research is crucial to validate these findings and develop evidence-based clinical protocols.
Descripción
Palabras clave
Preeclampsia con síntomas graves, Lactato sérico, Monitoreo clínico, Biomarcadores, Complicaciones maternas
Citación
Díaz-Pérez, Anderson. (2024). Correlaciones clínicas de los niveles de lactato sérico en pacientes con preeclampsia con síntomas graves. Gaceta Médica de Caracas. 132. 950-960. 10.47307/GMC.2024.132.4.8.
