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Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico

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datacite.identifier.urihttps://revistanefrologia.org/index.php/rcn/article/view/492
datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
dc.contributor.authorArrieta Bravo, Valentina
dc.contributor.authorRangel Gómez, Tiffany
dc.contributor.authorPacheco Lugo, Lisandro
dc.date.accessioned2022-01-26T16:26:23Z
dc.date.available2022-01-26T16:26:23Z
dc.date.issued2021
dc.description.abstractEl lupus eritematoso sistémico (LES) es una enfermedad compleja y altamente heterogénea que afecta múltiples órganos, incluyendo articulaciones, corazón, sistema hematopoyético, sistema nervioso y riñón, siendo este último el de peor pronóstico y el que conlleva a nefritis lúpica (NL). Aunque la etiopatogénesis del LES aún no se conoce con claridad, se cree que la susceptibilidad genética y las modificaciones epigenéticas aberrantes favorecen su desenlace. Para establecer una terapia precisa es necesario evaluar de manera eficiente y objetiva el compromiso de órganos y la actividad de la enfermedad, lo cual es muy difícil por las pocas pruebas de laboratorio clínico disponibles en la actualidad. En las últimas décadas la búsqueda de nuevos biomarcadores de LES ha sido una tendencia y se han identificado varios promisorios a nivel de genómica, metabolómica, proteómica y transcriptómica. En esta revisión se resume el estado del arte relacionado con estudios transcriptómicos que han identificado diversos transcritos potencialmente útiles como biomarcadores del LES y la NLspa
dc.description.abstractSystemic Lupus Erythematosus is a complex and highly heterogeneous disease affecting multiple organs such as joints, heart, hematopoietic system, nervous system and kidney, the latter being the worst prognosis and leading to lupus nephritis (LN). While the etiopathogenesis of SLE is still not completely clear, is believed that genetic susceptibility and aberrant epigenetic modifications favor the outcome of the disease. In order to establish an accurate therapy, it is necessary to efficiently and objectively assess organ involvement and disease activity, which is very dificult due to the clinical laboratory tests currently available. In recent decades, the search for new SLE biomarkers has been a trend and many promising biomarkers have been identified at the genomic, metabolomic, proteomic and transcriptomic levels. In this review we summarize the state of the art related to transcriptomic studies that have identified various potentially useful transcripts as biomarkers of SLE and NL.eng
dc.description.sponsorshipSystemic Lupus Erythematosus is a complex and highly heterogeneous disease affecting multiple organs such as joints, heart, hematopoietic system, nervous system and kidney, the latter being the worst prognosis and leading to lupus nephritis (LN). While the etiopathogenesis of SLE is still not completely clear, is believed that genetic susceptibility and aberrant epigenetic modifications favor the outcome of the disease. In order to establish an accurate therapy, it is necessary to efficiently and objectively assess organ involvement and disease activity, which is very dificult due to the clinical laboratory tests currently available. In recent decades, the search for new SLE biomarkers has been a trend and many promising biomarkers have been identified at the genomic, metabolomic, proteomic and transcriptomic levels. In this review we summarize the state of the art related to transcriptomic studies that have identified various potentially useful transcripts as biomarkers of SLE and NL.spa
dc.format.mimetypepdfspa
dc.identifier.doihttps://doi.org/10.22265/acnef.8.1.492
dc.identifier.issn25005006
dc.identifier.urihttps://hdl.handle.net/20.500.12442/9307
dc.language.isospaspa
dc.publisherAsociación Colombiana de Nefrología e hipertensión Arterialspa
dc.publisherFacultad de Ciencias de la Saludspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceVol. 8, Num. 1 (2021)spa
dc.sourceRevista Colombiana de Nefrología. Rev. Colomb. Nefrol.spa
dc.subjectLupus eritematoso sistémicospa
dc.subjectNefritis lúpicaspa
dc.subjectBiomarcadoresspa
dc.subjectMicroARNsspa
dc.subjectSystemic lupus erythematosuseng
dc.subjectLupus nephritiseng
dc.subjectBiomarkerseng
dc.subjectMicroRNAseng
dc.titleExplorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémicospa
dc.title.translatedExploring the power of transcriptomic approaches to identify biomarkers associated to renal damage in Systemic Lupus Erythematosus patientseng
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.spaArtículo científicospa
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