Relación de niveles de NS-1 con infección primaria/secundaria del virus del dengue en la costa colombiana.
| datacite.rights | http://purl.org/coar/access_right/c_16ec | spa |
| dc.contributor.advisor | Cadena Bonfanti, Andrés Ángelo | spa |
| dc.contributor.advisor | González Torrez, Henry Joseth | spa |
| dc.contributor.advisor | Chang, Aileen | spa |
| dc.contributor.advisor | Herrera Gómez, Carlos Andrés | spa |
| dc.contributor.author | López Sanjuanelo, Samira del Carmen | spa |
| dc.date.accessioned | 2023-01-17T15:40:34Z | |
| dc.date.available | 2023-01-17T15:40:34Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Introducción: La infección por dengue es una enfermedad transmitida por la picadura del mosquito hembra Aedes, principalmente de la especie Aedes aegypti, cuyos síntomas inician de 4 a 7 días posterior a la picadura del mosquito caracterizados por fiebre , dolor de cabeza y erupción cutánea, asociada además a complicaciones graves como hemorragias y shock las cuales son desencadenadas por compromiso en la permeabilidad vascular y mecanismos que reducen volumen plaquetario , considerada una de las principales causas de morbilidad y mortalidad a nivel mundial. Objetivo: Relacionar los niveles de NS-1 con infección primaria/secundaria del virus del dengue en el atlántico colombiano. Metodología: se realizó un estudio analítico, longitudinal, retrospectivo de carácter cuantitativo, con la participación de 36 pacientes incluyendo hombres, mujeres y niños con sintomatología y diagnostico serológico confirmado por laboratorio para el virus del dengue, ubicados en el departamento del atlántico y magdalena entre el año 2018- 2020. Todos los datos de los pacientes se almacenaban en la base de datos REDCap de la Universidad George Washington. | spa |
| dc.description.abstract | Introduction: Dengue infection is a disease transmitted by the bite of the female Aedes mosquito, mainly of the Aedes aegypti species, whose symptoms begin 4 to 7 days after the mosquito bite, characterized by fever, headache and skin rash, also associated with to serious complications such as hemorrhage and shock which are triggered by compromised vascular permeability and mechanisms that reduce platelet volume, considered one of the main causes of morbidity and mortality worldwide. Objective: To relate the levels of NS-1 with primary/secondary dengue virus infection in the Colombian Atlantic. Methodology: An analytical, longitudinal, retrospective quantitative study was carried out, with the participation of 36 patients including men, women and children over 8 with symptoms and laboratory-confirmed serological diagnosis for dengue virus located in the department of the Atlantic and the cupcake between the years 2018-2020. All patient data was stored in the George Washington University REDCap database. | spa |
| dc.format.mimetype | spa | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/11721 | |
| dc.language.iso | spa | spa |
| dc.publisher | Ediciones Universidad Simón Bolívar | spa |
| dc.publisher | Facultad de Ciencias de la Salud | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Dengue | spa |
| dc.subject | NS-1 | spa |
| dc.subject | Trombocitopenia | spa |
| dc.subject | Fuga plasmática | spa |
| dc.subject | Shock | spa |
| dc.subject | Serotipos | spa |
| dc.subject | Infección primaria | spa |
| dc.subject | Infección secundaria | spa |
| dc.subject | Thrombocytopenia | eng |
| dc.subject | Plasma leak | eng |
| dc.subject | Shock | eng |
| dc.subject | Serotypes | eng |
| dc.subject | Primary infection | eng |
| dc.subject | Secondary infection | eng |
| dc.title | Relación de niveles de NS-1 con infección primaria/secundaria del virus del dengue en la costa colombiana. | spa |
| dc.type.driver | info:eu-repo/semantics/other | spa |
| dc.type.spa | Otros | spa |
| dcterms.references | Áñez, G. (2007). Evolución molecular del virus dengue: Un área de investigación prioritaria. Investigación Clínica, 48(3), 273–276. | spa |
| dcterms.references | Avirutnan, P., Punyadee, N., Noisakran, S., Komoltri, C., Thiemmeca, S., Auethavornanan, K., Jairungsri, A., Kanlaya, R., Tangthawornchaikul, N., Puttikhunt, C., Pattanakitsakul, S.-N., Yenchitsomanus, P.-T., Mongkolsapaya, J., Kasinrerk, W., Sittisombut, N., Husmann, M., Blettner, M., Vasanawathana, S., Bhakdi, S., & Malasit, P. (2006). Vascular leakage in severe dengue virus infections: A potential role for the nonstructural viral protein NS1 and complement. The Journal of Infectious Diseases, 193(8), 1078–1088. https://doi.org/10.1086/500949 | spa |
| dcterms.references | Balsitis, S. J., Coloma, J., Castro, G., Alava, A., Flores, D., McKerrow, J. H., Beatty, P. R., & Harris, E. (2009). Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. The American Journal of Tropical Medicine and Hygiene, 80(3), 416–424. | spa |
| dcterms.references | Beatty, P. R., Puerta-Guardo, H., Killingbeck, S. S., Glasner, D. R., Hopkins, K., & Harris, E. (2015). Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination. Science Translational Medicine, 7(304), 304ra141. https://doi.org/10.1126/scitranslmed.aaa3787 | spa |
| dcterms.references | Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., Myers, M. F., George, D. B., Jaenisch, T., Wint, G. R. W., Simmons, C. P., Scott, T. W., 5 Farrar, J. J., & Hay, S. I. (2013). The global distribution and burden of dengue. Nature, 496(7446), 504–507. https://doi.org/10.1038/nature12060 | spa |
| dcterms.references | Boletín Epidemiológico. (n.d.). Retrieved October 13, 2022, from https://www.ins.gov.co/buscador-eventos/Paginas/Vista-Boletin-Epidemilogico.aspx | spa |
| dcterms.references | Bossi, F., Fischetti, F., Pellis, V., Bulla, R., Ferrero, E., Mollnes, T. E., Regoli, D., & Tedesco, F. (2004). Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. Journal of Immunology (Baltimore, Md.: 1950), 173(11), 6921–6927. https://doi.org/10.4049/jimmunol.173.11.6921 | spa |
| dcterms.references | Cardier, J. E., Balogh, V., Perez-Silva, C., Romano, E., Rivas, B., Bosch, N., & Rothman, A. L. (2006). Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease. Cytokine, 34(3–4), 155–160. https://doi.org/10.1016/j.cyto.2006.04.002 | spa |
| dcterms.references | Cass, L. M., Efthymiopoulos, C., & Bye, A. (1999). Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers. Clinical Pharmacokinetics, 36 Suppl 1, 1–11. https://doi.org/10.2165/00003088-199936001-00001 | spa |
| dcterms.references | Chang, H.-H., Shyu, H.-F., Wang, Y.-M., Sun, D.-S., Shyu, R.-H., Tang, S.-S., & Huang, Y.-S. (2002). Facilitation of cell adhesion by immobilized dengue viral nonstructural protein 1 (NS1): Arginine-glycine-aspartic acid structural mimicry within the dengue viral NS1 antigen. The Journal of Infectious Diseases, 186(6), 743–751. https://doi.org/10.1086/342600 | spa |
| dcterms.references | Chao, C.-H., Wu, W.-C., Lai, Y.-C., Tsai, P.-J., Perng, G.-C., Lin, Y.-S., & Yeh, T.-M. (2019). Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLoS Pathogens, 15(4), e1007625. https://doi.org/10.1371/journal.ppat.1007625 | spa |
| dcterms.references | de Azeredo, E. L., Monteiro, R. Q., & de-Oliveira Pinto, L. M. (2015). Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Mediators of Inflammation, 2015, 313842. https://doi.org/10.1155/2015/313842 | spa |
| dcterms.references | Dengue y dengue grave. (n.d.). Retrieved October 13, 2022, from https://www.who.int/es/news-room/fact-sheets/detail/dengue-and-severe-dengue | spa |
| dcterms.references | Espinosa, D. A., Beatty, P. R., Puerta-Guardo, H., Islam, M. N., Belisle, J. T., Perera, R., & Harris, E. (2019). Increased serum sialic acid is associated with morbidity and mortality in a murine model of dengue disease. The Journal of General Virology, 100(11), 1515–1522. https://doi.org/10.1099/jgv.0.001319 | spa |
| dcterms.references | Glasner, D. R., Puerta-Guardo, H., Beatty, P. R., & Harris, E. (2018). The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis. Annual Review of Virology, 5(1), 227–253. https://doi.org/10.1146/annurev-virology-101416-041848 | spa |
| dcterms.references | Grinnell, F., Billingham, R. E., & Burgess, L. (1981). Distribution of fibronectin during wound healing in vivo. The Journal of Investigative Dermatology, 76(3), 181–189. https://doi.org/10.1111/1523-1747.ep12525694 | spa |
| dcterms.references | Halstead, S. B. (1980a). Dengue haemorrhagic fever—A public health problem and a field for research. Bulletin of the World Health Organization, 58(1), 1–21. | spa |
| dcterms.references | Halstead, S. B. (1980b). Fiebre hemorrágica del dengue: Un problema de salud pública y un campo de investigación. Boletín de La Organización Mundial de La Salud., 58. | spa |
| dcterms.references | Infecciones por virus y rickettsias | Diagnóstico clínico y tratamiento, 2017 | AccessMedicina | McGraw Hill Medical. (n.d.). Retrieved October 13, 2022, from https://accessmedicina.mhmedical.com/content.aspx?bookid=2197§ionid=174409706 | spa |
| dcterms.references | Jawetz, Melnick & Adelberg Microbiología Médica, 28e | AccessMedicina | McGraw Hill Medical. (n.d.). Retrieved October 13, 2022, from https://accessmedicina.mhmedical.com/book.aspx?bookID=2955 | spa |
| dcterms.references | Kurosu, T., Chaichana, P., Yamate, M., Anantapreecha, S., & Ikuta, K. (2007). Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1. Biochemical and Biophysical Research Communications, 362(4), 1051–1056. https://doi.org/10.1016/j.bbrc.2007.08.137 | spa |
| dcterms.references | La Russa, V. F., & Innis, B. L. (1995). Mechanisms of dengue virus-induced bone marrow suppression. Bailliere’s Clinical Haematology, 8(1), 249–270. https://doi.org/10.1016/s0950-3536(05)80240-9 | spa |
| dcterms.references | Libraty, D. H., Young, P. R., Pickering, D., Endy, T. P., Kalayanarooj, S., Green, S., Vaughn, D. W., Nisalak, A., Ennis, F. A., & Rothman, A. L. (2002). High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. The Journal of Infectious Diseases, 186(8), 1165–1168. https://doi.org/10.1086/343813 | spa |
| dcterms.references | Lin, C. F., Lei, H. Y., Liu, C. C., Liu, H. S., Yeh, T. M., Wang, S. T., Yang, T. I., Sheu, F. C., Kuo, C. F., & Lin, Y. S. (2001). Generation of IgM anti-platelet autoantibody in dengue patients. Journal of Medical Virology, 63(2), 143–149. | spa |
| dcterms.references | Lin, G.-L., Chang, H.-H., Lien, T.-S., Chen, P.-K., Chan, H., Su, M.-T., Liao, C.-Y., & Sun, D.-S. (2017). Suppressive effect of dengue virus envelope protein domain III on megakaryopoiesis. Virulence, 8(8), 1719–1731. https://doi.org/10.1080/21505594.2017.1343769 | spa |
| dcterms.references | Lytton, S. D., Nematollahi, G., van Tong, H., Xuan Anh, C., Hung, H. V., Hoan, N. X., Diez, G., Schumacher, T., Landt, O., Melchior, W., Fuchs, D., Toan, N. L., Velavan, T. P., & Song, L. H. (2020). Predominant secondary dengue infection among Vietnamese adults mostly without warning signs and severe disease. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 100, 316–323. https://doi.org/10.1016/j.ijid.2020.08.082 | spa |
| dcterms.references | Malavige, G. N., & Ogg, G. S. (2017). Pathogenesis of vascular leak in dengue virus infection. Immunology, 151(3), 261–269. https://doi.org/10.1111/imm.12748 | spa |
| dcterms.references | Mapua, C. A., Inoue, S., Cruz, D. J. M., Pancho, M. A. M., Tanig, C. Z., Nagatake, T., Matias, R. R., Morita, K., Carlos, C. C., Natividad, F. F., Oishi, K., Igarashi, A., & Cinco, M. T. D. D. (2005). COMPARISON OF CLINICAL FEATURES AND HEMATOLOGIC ABNORMALITIES BETWEEN DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER AMONG CHILDREN IN THE PHILIPPINES. The American Journal of Tropical Medicine and Hygiene, 73(2), 435–440. https://doi.org/10.4269/ajtmh.2005.73.435 | spa |
| dcterms.references | Markiewski, M. M., Nilsson, B., Ekdahl, K. N., Mollnes, T. E., & Lambris, J. D. (2007). Complement and coagulation: Strangers or partners in crime? Trends in Immunology, 28(4), 184–192. https://doi.org/10.1016/j.it.2007.02.006 | spa |
| dcterms.references | Martínez-Cuellar, C., Lovera, D., Galeano, F., Gatti, L., & Arbo, A. (2020). Non-structural protein 1 (NS1) of dengue virus detection correlates with severity in primary but not in secondary dengue infection. Journal of Clinical Virology, 124, 104259. https://doi.org/10.1016/j.jcv.2020.104259 | spa |
| dcterms.references | Muller, D. A., Depelsenaire, A. C. I., & Young, P. R. (2017). Clinical and Laboratory Diagnosis of Dengue Virus Infection. The Journal of Infectious Diseases, 215(suppl_2), S89–S95. https://doi.org/10.1093/infdis/jiw649 | spa |
| dcterms.references | Puerta-Guardo, H., Glasner, D. R., & Harris, E. (2016). Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. PLoS Pathogens, 12(7), e1005738. https://doi.org/10.1371/journal.ppat.1005738 | spa |
| dcterms.references | Reyes, A. J. R., Ruge, D. G., & Herrera, L. C. P. (2019). INFORME DE EVENTO DENGUE, COLOMBIA, 2019. 04, 24. | spa |
| dcterms.references | Soo, K.-M., Khalid, B., Ching, S.-M., & Chee, H.-Y. (2016). Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections. PloS One, 11(5), e0154760. https://doi.org/10.1371/journal.pone.0154760 | spa |
| dcterms.references | Sun, D.-S., King, C.-C., Huang, H.-S., Shih, Y.-L., Lee, C.-C., Tsai, W.-J., Yu, C.-C., & Chang, H.-H. (2007). Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice. Journal of Thrombosis and Haemostasis: JTH, 5(11), 2291–2299. https://doi.org/10.1111/j.1538-7836.2007.02754.x | spa |
| dcterms.references | Woon, Y. L., Hor, C. P., Hussin, N., Zakaria, A., Goh, P. P., & Cheah, W. K. (2016). A Two-Year Review on Epidemiology and Clinical Characteristics of Dengue Deaths in Malaysia, 2013-2014. PLoS Neglected Tropical Diseases, 10(5), e0004575. https://doi.org/10.1371/journal.pntd.0004575 | spa |
| dcterms.references | World Health Organization. Regional Office for South-East Asia. (2011). Comprehensive Guideline for Prevention and Control of Dengue and Dengue Haemorrhagic Fever. Revised and expanded edition. WHO Regional Office for South-East Asia. https://apps.who.int/iris/handle/10665/204894 | spa |
| oaire.version | info:eu-repo/semantics/acceptedVersion | spa |
| sb.programa | Especialización en Medicina Interna | spa |
| sb.sede | Sede Barranquilla | spa |