Obesity-Related kidney disease: A growing threat to renal health
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Fecha
2025
Autores
León-Román, Juan Carlos
López Martínez, Marina
Esteves, Alexandra
Ciudin, Andreea
Núñez Delgado, Sara
Álvarez, Tiffany
Lecube, Albert
Rico-Fontalvo, Jorge
Soler, María José
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MDPI
Resumen
Obesity represents a serious and growing disease worldwide. The pathophysiological
changes secondary to chronic inflammation lead to the development of diseases that increase the morbidity and mortality of individuals. Chronic kidney disease (CKD) is a
condition with deleterious effects that acts bidirectionally with obesity. From approximately 20% to 30% of individuals share phenotypes of CKD and obesity, increasing their
cardiovascular risk and the risk of other complications. Obesity and CKD form a vicious
cycle in which inflammation is the central axis of multiorgan damage. Despite increasing
the risk of cardiac and renal mortality, CKD progresses in relation to body mass index and
albuminuria. Nowadays, the implementation of the new medications aimed at mitigating
the peak of inflammation is becoming a cornerstone of treatments for obesity, diabetes,
cardiovascular diseases, and renal disease.
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León-Román, J.; López-Martínez, M.; Esteves, A.; Ciudin, A.; Núñez-Delgado, S.; Álvarez, T.; Lecube, A.; Rico-Fontalvo, J.; Soler, M.J. Obesity-Related Kidney Disease: A Growing Threat to Renal Health. Int. J. Mol. Sci. 2025, 26, 6641. https://doi.org/10.3390/ijms26146641
