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Enfermedad de Huntington: una aproximación desde la investigación

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorSánchez-Rojas, Manuel
dc.contributor.authorPuentes Rozo, Pedro
dc.contributor.authorPineda, David A.
dc.contributor.authorAcosta-López, Johan
dc.contributor.authorMejía-Segura, Elsy
dc.contributor.authorCervantes-Henríquez, Martha
dc.contributor.authorMartínez-Banfi, Martha
dc.contributor.authorAhmad, Mostapha
dc.contributor.authorRosa Ríos Anillo, Margarita
dc.contributor.authorPineda-Alhucema, Wilmar
dc.contributor.authorNoguera-Machacón, Luz M.
dc.contributor.authorDe la Hoz, Moisés
dc.contributor.authorJiménez-Figueroa, Giomar
dc.contributor.authorEscudero-Cabarcas, Johana
dc.contributor.authorArcos-Burgos, Mauricio
dc.contributor.authorVélez, Jorge I.
dc.contributor.authorMontoya Grajeda, José
dc.contributor.authorRodríguez Gómez, Odette
dc.contributor.authorRuvalcaba Medina, Anareli
dc.contributor.authorHernández Panduro, Carlos
dc.contributor.authorDe la Luz Escalante, Horacio
dc.contributor.authorOrdeñana Xicotencatl, Letty
dc.contributor.authorCarmona Rúa, Geraldine
dc.contributor.authorVergara Ortega, Katiana
dc.contributor.authorMuñoz, Yulieth
dc.contributor.authorChacón, Tatiana
dc.contributor.authorEspaña Roa, Siria
dc.contributor.authorSánchez-Barrios, Cristian
dc.date.accessioned2023-02-08T13:30:10Z
dc.date.available2023-02-08T13:30:10Z
dc.date.issued2021
dc.description.abstractLa Enfermedad de Huntington es una enfermedad huérfana, con sintomatología descrita en su etapa clínica, pero con manifestaciones psiquiátricas en etapa prodrómica aun no formalmente caracterizadas. Objetivo: Identificar los principales trastornos mentales en pacientes en la etapa prodrómica de la Enfermedad de Huntington, así como los instrumentos utilizados para la captación de estos síntomas. Materiales y Métodos: Se realizó la revisión de acuerdo con la declaración PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). La búsqueda se realizó en las bases de datos de Medline, Scopus, Medscape y en el portal web del estudio PREDICT-HD. Se usaron MeSH (Medical Subject Headings) y términos comunes para formular las estrategias de búsqueda. Resultados: De 159 estudios revisados, 4 fueron incluidos por la descripción de los instrumentos, los cuales fueron realizados en The University of Iowa, USA, pertenecientes al estudio PREDICT-HD (estudio observacional longitudinal diseñado para identificar marcadores neurobiológicos antes del inicio de la sintomatología motora de la EH); Se encontraron que la fatiga o baja energía está más relacionada con la alteración de la capacidad funcional, que la depresión en pacientes pre-HD; adicionalmente, los síntomas depresivos e historia de intento de suicidio se identificaron como factores de riesgo elevado en pacientes más cercanos al diagnóstico motor, de la misma manera la inconciencia incrementa en la progresión de HD durante el estado prodrómico en estos grupos. Conclusiones: Actualmente no existe un instrumento validado que contenga una amplia sensibilidad y especificidad a nivel mundial para captar manifestaciones psiquiátricas en la etapa presintomática de la enfermedad y que esta patología a pesar de tener una gran sintomatología descrita en su etapa clínica no presenta formalmente caracterizadas manifestaciones psiquiátricas en la etapa pre-HD.spa
dc.format.mimetypepdfspa
dc.identifier.isbn9786287533059 (versión digital)
dc.identifier.isbn9786287533042 (versión impresa)
dc.identifier.urihttps://hdl.handle.net/20.500.12442/11816
dc.language.isospaspa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEnfermedad de Huntingtonspa
dc.subjectEnfermedades genéticasspa
dc.titleEnfermedad de Huntington: una aproximación desde la investigaciónspa
dc.type.driverinfo:eu-repo/semantics/bookeng
dc.type.spaLibrospa
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