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The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorOrtega, Ángel
dc.contributor.authorVera, Ivana
dc.contributor.authorDiaz, Maria P.
dc.contributor.authorNavarro, Carla
dc.contributor.authorRojas, Milagros
dc.contributor.authorTorres, Wheeler
dc.contributor.authorParra, Heliana
dc.contributor.authorSalazar, Juan
dc.contributor.authorDe Sanctis, Juan B.
dc.contributor.authorBermúdez, Valmore
dc.date.accessioned2022-04-01T18:28:42Z
dc.date.available2022-04-01T18:28:42Z
dc.date.issued2022
dc.description.abstractThe yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.eng
dc.format.mimetypepdfspa
dc.identifier.citationOrtega, Á.; Vera, I.; Diaz, M.P.; Navarro, C.; Rojas, M.; Torres, W.; Parra, H.; Salazar, J.; Sanctis, J.B.D.; Bermúdez, V. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises. Int. J. Mol. Sci. 2022, 23, 430. https://doi.org/ 10.3390/ijms23010430eng
dc.identifier.doihttps://doi.org/10.3390/ijms23010430
dc.identifier.issn14220067
dc.identifier.urihttps://hdl.handle.net/20.500.12442/9506
dc.language.isoengeng
dc.publisherMDPIspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceInternational Journal of Molecular Scienceseng
dc.sourceVol. 23, No. 1 (2022)
dc.subjectYAP/TAZeng
dc.subjectHippo signaling pathwayeng
dc.subjectcarcinogenesiseng
dc.subjectTumor microenvironmenteng
dc.subjectneoplastic stem cellseng
dc.subjectcell proliferationeng
dc.subjectdrug resistanceeng
dc.subjectchemoresistanceeng
dc.subjectimmunotherapyeng
dc.titleThe YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promiseseng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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