The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | eng |
| dc.contributor.author | Ortega, Ángel | |
| dc.contributor.author | Vera, Ivana | |
| dc.contributor.author | Diaz, Maria P. | |
| dc.contributor.author | Navarro, Carla | |
| dc.contributor.author | Rojas, Milagros | |
| dc.contributor.author | Torres, Wheeler | |
| dc.contributor.author | Parra, Heliana | |
| dc.contributor.author | Salazar, Juan | |
| dc.contributor.author | De Sanctis, Juan B. | |
| dc.contributor.author | Bermúdez, Valmore | |
| dc.date.accessioned | 2022-04-01T18:28:42Z | |
| dc.date.available | 2022-04-01T18:28:42Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed. | eng |
| dc.format.mimetype | spa | |
| dc.identifier.citation | Ortega, Á.; Vera, I.; Diaz, M.P.; Navarro, C.; Rojas, M.; Torres, W.; Parra, H.; Salazar, J.; Sanctis, J.B.D.; Bermúdez, V. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises. Int. J. Mol. Sci. 2022, 23, 430. https://doi.org/ 10.3390/ijms23010430 | eng |
| dc.identifier.doi | https://doi.org/10.3390/ijms23010430 | |
| dc.identifier.issn | 14220067 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/9506 | |
| dc.language.iso | eng | eng |
| dc.publisher | MDPI | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | International Journal of Molecular Sciences | eng |
| dc.source | Vol. 23, No. 1 (2022) | |
| dc.subject | YAP/TAZ | eng |
| dc.subject | Hippo signaling pathway | eng |
| dc.subject | carcinogenesis | eng |
| dc.subject | Tumor microenvironment | eng |
| dc.subject | neoplastic stem cells | eng |
| dc.subject | cell proliferation | eng |
| dc.subject | drug resistance | eng |
| dc.subject | chemoresistance | eng |
| dc.subject | immunotherapy | eng |
| dc.title | The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises | eng |
| dc.type.driver | info:eu-repo/semantics/article | eng |
| dc.type.spa | Artículo científico | spa |
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