The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises
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Fecha
2022
Autores
Ortega, Ángel
Vera, Ivana
Diaz, Maria P.
Navarro, Carla
Rojas, Milagros
Torres, Wheeler
Parra, Heliana
Salazar, Juan
De Sanctis, Juan B.
Bermúdez, Valmore
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Editor
MDPI
Resumen
The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways’ role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.
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Palabras clave
YAP/TAZ, Hippo signaling pathway, carcinogenesis, Tumor microenvironment, neoplastic stem cells, cell proliferation, drug resistance, chemoresistance, immunotherapy
Citación
Ortega, Á.; Vera, I.; Diaz,
M.P.; Navarro, C.; Rojas, M.; Torres,
W.; Parra, H.; Salazar, J.; Sanctis,
J.B.D.; Bermúdez, V. The YAP/TAZ
Signaling Pathway in the Tumor
Microenvironment and
Carcinogenesis: Current Knowledge
and Therapeutic Promises. Int. J. Mol.
Sci. 2022, 23, 430. https://doi.org/
10.3390/ijms23010430
