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Genetic variation underpinning ADHD risk in a caribbean community

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dc.contributor.authorPuentes-Rozo, Pedro J.
dc.contributor.authorAcosta-López, Johan E.
dc.contributor.authorCervantes-Henríquez, Martha L.
dc.contributor.authorMartínez-Banfi, Martha L.
dc.contributor.authorMejia-Segura, Elsy
dc.contributor.authorSánchez-Rojas, Manuel
dc.contributor.authorAnaya-Romero, Marco E.
dc.contributor.authorAcosta-Hoyos, Antonio
dc.contributor.authorGarcía-Llinás, Guisselle A.
dc.contributor.authorMastronardi, Claudio A.
dc.contributor.authorPineda, David A.
dc.contributor.authorCastellanos, F. Xavier
dc.contributor.authorArcos-Burgos, Mauricio
dc.contributor.authorVélez, Jorge I.
dc.date.accessioned2019-09-03T15:34:39Z
dc.date.available2019-09-03T15:34:39Z
dc.date.issued2019
dc.description.abstractAttention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 10x-4), rs2282794-FGF1 (A allele; p = 1.33 10x-2), rs2122642-ADGRL3 (C allele, p = 3.5 10x-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.eng
dc.identifier.issn20734409
dc.identifier.urihttps://hdl.handle.net/20.500.12442/3886
dc.language.isoengeng
dc.publisherPublished by MDPeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceRevista Cellspa
dc.sourceVol. 8 No. 8 (2019)spa
dc.source.urihttps://doi.org/10.3390/cells8080907spa
dc.subjectADHDeng
dc.subjectADGRL3eng
dc.subjectLPHN3eng
dc.subjectSNAP25eng
dc.subjectFGF1eng
dc.subjectGeneticseng
dc.subjectCaribbean communityeng
dc.subjectFBATeng
dc.subjectPredictive genomicseng
dc.titleGenetic variation underpinning ADHD risk in a caribbean communityeng
dc.typearticleeng
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