Genetic variation underpinning ADHD risk in a caribbean community
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Fecha
2019
Autores
Puentes-Rozo, Pedro J.
Acosta-López, Johan E.
Cervantes-Henríquez, Martha L.
Martínez-Banfi, Martha L.
Mejia-Segura, Elsy
Sánchez-Rojas, Manuel
Anaya-Romero, Marco E.
Acosta-Hoyos, Antonio
García-Llinás, Guisselle A.
Mastronardi, Claudio A.
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Published by MDP
Resumen
Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent
neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic
studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3),
SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs
harboured in genes previously reported to be associated with ADHD and evaluated their potential
association in 386 individuals belonging to 113 nuclear families from a Caribbean community in
Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele;
p = 2.46 10x-4), rs2282794-FGF1 (A allele; p = 1.33 10x-2), rs2122642-ADGRL3 (C allele, p = 3.5
10x-2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted =
0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD
conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African
American component, and provide evidence supporting the existence of specific patterns of genetic
stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial
to define risk and predict susceptibility to disease.
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Palabras clave
ADHD, ADGRL3, LPHN3, SNAP25, FGF1, Genetics, Caribbean community, FBAT, Predictive genomics
