Caracterización Genómica del Bacteriófago vB_EcoP_BaqEco_A
| datacite.rights | http://purl.org/coar/access_right/c_f1cf | |
| dc.contributor.advisor | Lozano Solano, Dayan | |
| dc.contributor.author | Quiñones Vásquez, Solangie | |
| dc.date.accessioned | 2025-07-01T21:55:28Z | |
| dc.date.available | 2025-07-01T21:55:28Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | La resistencia a los antibióticos representa una amenaza creciente para la salud pública global, lo que ha impulsado la búsqueda urgente de estrategias terapéuticas alternativas. Los bacteriófagos, en especial aquellos que codifican enzimas líticas como las endolisinas, han surgido como agentes prometedores capaces de eliminar bacterias resistentes sin afectar las células humanas ni alterar la microbiota beneficiosa. No obstante, la escasa caracterización genómica y funcional de nuevos fagos limita su aplicación clínica. En este estudio, se caracterizó el fago vB_EcoP_BaqEcoA, evidenciando una organización genómica modular y la presencia de un gen que codifica un ARNt para arginina. Esta característica podría mejorar su eficiencia lítica contra Escherichia coli y respalda su clasificación dentro de la familia Kuravirus. Estos hallazgos contribuyen al creciente catálogo de fagos con potencial terapéutico y destacan la importancia de seguir explorando la biodiversidad fágica como herramienta frente a infecciones bacterianas multirresistentes. | spa |
| dc.description.abstract | Antibiotic resistance poses a growing threat to global public health, prompting the urgent need for alternative therapeutic strategies. Bacteriophages, particularly those encoding lytic enzymes such as endolysins, have emerged as promising agents capable of selectively targeting resistant bacteria without harming human cells or disrupting beneficial microbiota. Despite this potential, the limited genomic and functional characterization of novel phages hinders their clinical application. In this study, we characterized the phage vB_EcoP_BaqEcoA, revealing a modular genomic organization and the presence of a gene encoding a tRNA for arginine. This genomic feature may enhance its lytic efficiency against Escherichia coli and supports its classification within the Kuravirus family. These findings contribute to the expanding catalog of phages with therapeutic potential and highlight the importance of continued exploration of phage biodiversity for combating multidrug-resistant bacterial infections. | eng |
| dc.format.mimetype | ||
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/16780 | |
| dc.language.iso | spa | |
| dc.publisher | Ediciones Universidad Simón Bolívar | spa |
| dc.publisher | Facultad de Ciencias Básicas y Biomédicas | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | eng |
| dc.rights.accessrights | info:eu-repo/semantics/embargoedAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Bacteriófago | spa |
| dc.subject | Escherichia coli | spa |
| dc.subject | Fagoterapia | spa |
| dc.subject | Anotación | spa |
| dc.subject.keywords | Bacteriophage | eng |
| dc.subject.keywords | Escherichia coli | eng |
| dc.subject.keywords | Phage therapy | eng |
| dc.subject.keywords | Annotation | eng |
| dc.title | Caracterización Genómica del Bacteriófago vB_EcoP_BaqEco_A | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | |
| dc.type.spa | Trabajo de grado máster | |
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| oaire.version | info:eu-repo/semantics/acceptedVersion | |
| sb.investigacion | Genética microbiana | spa |
| sb.programa | Maestría en Genética | spa |
| sb.sede | Sede Barranquilla | spa |
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