Caracterización Genómica del Bacteriófago vB_EcoP_BaqEco_A
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Fecha
2025
Autores
Quiñones Vásquez, Solangie
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias Básicas y Biomédicas
Facultad de Ciencias Básicas y Biomédicas
Resumen
La resistencia a los antibióticos representa una amenaza creciente para la salud pública global, lo que ha
impulsado la búsqueda urgente de estrategias terapéuticas alternativas. Los bacteriófagos, en especial
aquellos que codifican enzimas líticas como las endolisinas, han surgido como agentes prometedores
capaces de eliminar bacterias resistentes sin afectar las células humanas ni alterar la microbiota
beneficiosa. No obstante, la escasa caracterización genómica y funcional de nuevos fagos limita su
aplicación clínica. En este estudio, se caracterizó el fago vB_EcoP_BaqEcoA, evidenciando una
organización genómica modular y la presencia de un gen que codifica un ARNt para arginina. Esta
característica podría mejorar su eficiencia lítica contra Escherichia coli y respalda su clasificación dentro
de la familia Kuravirus. Estos hallazgos contribuyen al creciente catálogo de fagos con potencial
terapéutico y destacan la importancia de seguir explorando la biodiversidad fágica como herramienta
frente a infecciones bacterianas multirresistentes.
Antibiotic resistance poses a growing threat to global public health, prompting the urgent need for alternative therapeutic strategies. Bacteriophages, particularly those encoding lytic enzymes such as endolysins, have emerged as promising agents capable of selectively targeting resistant bacteria without harming human cells or disrupting beneficial microbiota. Despite this potential, the limited genomic and functional characterization of novel phages hinders their clinical application. In this study, we characterized the phage vB_EcoP_BaqEcoA, revealing a modular genomic organization and the presence of a gene encoding a tRNA for arginine. This genomic feature may enhance its lytic efficiency against Escherichia coli and supports its classification within the Kuravirus family. These findings contribute to the expanding catalog of phages with therapeutic potential and highlight the importance of continued exploration of phage biodiversity for combating multidrug-resistant bacterial infections.
Antibiotic resistance poses a growing threat to global public health, prompting the urgent need for alternative therapeutic strategies. Bacteriophages, particularly those encoding lytic enzymes such as endolysins, have emerged as promising agents capable of selectively targeting resistant bacteria without harming human cells or disrupting beneficial microbiota. Despite this potential, the limited genomic and functional characterization of novel phages hinders their clinical application. In this study, we characterized the phage vB_EcoP_BaqEcoA, revealing a modular genomic organization and the presence of a gene encoding a tRNA for arginine. This genomic feature may enhance its lytic efficiency against Escherichia coli and supports its classification within the Kuravirus family. These findings contribute to the expanding catalog of phages with therapeutic potential and highlight the importance of continued exploration of phage biodiversity for combating multidrug-resistant bacterial infections.
Descripción
Palabras clave
Bacteriófago, Escherichia coli, Fagoterapia, Anotación
