Asociación entre noveles elevados de lipoproteína(a) (≥50 MG/DL) y la presencia de enfermedad cardiovascular aterosclerótica establecida en adultos de Barranquilla, Colombia
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Fecha
2026
Autores
Mercado Marchena, Riguey Cecilia
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
Antecedentes: La enfermedad cardiovascular aterosclerótica (ECVA) constituye una causa principal de morbimortalidad. La lipoproteína(a) es un marcador predominantemente genético con propiedades aterogénicas y protrombóticas; el umbral ≥50 mg/dL se usa con frecuencia para definir niveles elevados. En el Caribe colombiano, la evidencia clínica local sobre la frecuencia de Lp(a) elevada y su asociación con ECVA establecida es limitada.
Objetivo: Analizar la asociación entre Lp(a) ≥50 mg/dL y la presencia de ECVA establecida en una población adulta atendida en Barranquilla, Colombia.
Métodos: Estudio observacional analítico, transversal retrospectivo, realizado en una IPS de cuarto nivel en Barranquilla entre el 01 de enero de 2024 y el 30 de agosto de 2025. Se incluyeron adultos (≥18 años) con medición de Lp(a) y evaluación clínica documentada (n = 492), mediante muestreo no probabilístico por conveniencia. La exposición principal fue Lp(a).
Background: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality. Lipoprotein(a) [Lp(a)] is a predominantly genetically determined biomarker with atherogenic and prothrombotic properties; a threshold of ≥50 mg/dL is commonly used to define elevated levels. In the Colombian Caribbean region, local clinical evidence on the frequency of elevated Lp(a) and its association with established ASCVD is limited. Objective: To analyze the association between Lp(a) ≥50 mg/dL and the presence of established ASCVD in an adult population receiving care in Barranquilla, Colombia. Methods: An observational, analytical, retrospective cross-sectional study was conducted at a quaternary-care institution in Barranquilla between January 1, 2024 and August 30, 2025. Adults (≥18 years) with an Lp(a) measurement and documented clinical evaluation were included (n = 492) using non-probabilistic convenience sampling. The primary exposure was Lp(a)
Background: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality. Lipoprotein(a) [Lp(a)] is a predominantly genetically determined biomarker with atherogenic and prothrombotic properties; a threshold of ≥50 mg/dL is commonly used to define elevated levels. In the Colombian Caribbean region, local clinical evidence on the frequency of elevated Lp(a) and its association with established ASCVD is limited. Objective: To analyze the association between Lp(a) ≥50 mg/dL and the presence of established ASCVD in an adult population receiving care in Barranquilla, Colombia. Methods: An observational, analytical, retrospective cross-sectional study was conducted at a quaternary-care institution in Barranquilla between January 1, 2024 and August 30, 2025. Adults (≥18 years) with an Lp(a) measurement and documented clinical evaluation were included (n = 492) using non-probabilistic convenience sampling. The primary exposure was Lp(a)
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Palabras clave
Lipoproteína(a), Enfermedad cardiovascular aterosclerótica, Factores de riesgo, Estudios transversales
