Statin associated adverse reactions in Latin America: a scoping review
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Fecha
2021
Autores
Urina-Jassir, Manuel
Pacheco-Paez, Tatiana
Paez-Canro, Carol
Urina-Triana, Miguel
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BMJ Publishing Group
Resumen
Objectives We aim to describe the frequency and type
of adverse drug reactions (ADRs) in patients on statins in
published studies from Latin American (LATAM) countries.
Design Scoping review.
Methods A literature search was conducted in three
databases (PubMed, EMBASE and LILACS) in addition
to a manual search in relevant journals from LATAM
universities or medical societies. A snowballing technique
was used to identify further references. Randomised
controlled trials (RCTs) and observational studies between
2000 and 2020 were included. Studies were considered
eligible if they included adults on statin therapy from
LATAM and reported data on ADRs. Data on ADRs were
abstracted and presented by study design.
Results Out of 8076 articles, a total of 20 studies were
included (7 RCTs and 13 observational studies). We
identified three head-to-head statin RCTs, two statinversus-policosanol RCTs and only two placebo-controlled
trials. The statin-related ADRs frequency ranged from
0% to 35.1% in RCTs and 0% to 28.4% in observational
studies. The most common ADRs were muscle-related
events including myalgia and elevated creatine
phosphokinase. Other reported ADRs were gastrointestinal
symptoms, headache and altered fasting plasma glucose.
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Urina-Jassir M, Pacheco-Paez T, Paez-Canro C, et al. Statin associated adverse reactions in Latin America: a scoping review. BMJ Open 2021;11:e050675. doi:10.1136/ bmjopen-2021-050675
