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Comprehensive approach to skin ulcers caused by calciphylaxis in a patient with chronic renal failure, treated with topical sodium thiosulfate ointment: A case report

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datacite.rightshttp://purl.org/coar/access_right/c_abf2
dc.contributor.authorBertarini, Maria Florencia
dc.contributor.authorBelatti, Anahi Lorena
dc.contributor.authorGuido Musso, Carlos
dc.contributor.authorAroca-Martinez, Gustavo
dc.contributor.authorBohmer, Laura Vanesa
dc.contributor.authorEnz, Paula Andrea
dc.contributor.authorMazzuoccolo, Luis Daniel
dc.date.accessioned2025-09-30T20:28:10Z
dc.date.available2025-09-30T20:28:10Z
dc.date.issued2025
dc.description.abstractPurpose: This clinical case report aims to document the successful management of calcific arteriolopathy, also known as calciphylaxis, in a 74-year-old male patient with multiple comorbidities, including chronic kidney disease. The primary objectives were to highlight the effectiveness of a multidisciplinary approach –particularly the use of topical sodium thiosulfate– and to demonstrate the positive impact on glomerular filtration rate (GFR) following wound healing. Methods: The patient presented with two ulcers on the posterior aspect of the right leg, which developed after hospitalization for congestive heart failure. A comprehensive treatment strategy was employed, involving multiple medical specialties, including infectious disease, nephrology, and dermatology. Treatment included intravenous antibiotics, pain management, transitioning to new-generation anticoagulants, and the use of a unique ointment containing sodium thiosulfate for wound care. Results: After seven months, the patient achieved complete wound healing, and his glomerular filtration rate improved significantly. Three consecutive measurements of renal filtration parameters confirmed this positive impact. The topical application of sodium thiosulfate played a crucial role in wound healing, highlighting its potential as a treatment option for calciphylaxis. Conclusion: This case underscores the importance of interdisciplinary management in calcific arteriolopathy, addressing both underlying causes and localized wound care. The successful outcome and improved renal function following wound healing suggest that topical sodium thiosulfate can be a valuable treatment approach, particularly when systemic therapy is challenging. This report contributes to the limited literature on the topical use of sodium thiosulfate in calciphylaxis and emphasizes the need for comprehensive care in patients with this condition.eng
dc.description.abstractObjetivo: documentar el manejo exitoso de la arteriolopatía calcificante (calcifilaxis) en un paciente varón de 74 años con múltiples comorbilidades, incluida la enfermedad renal crónica. Se buscó destacar principalmente la efectividad de un abordaje multidisciplinario, acompañado del tratamiento local de tiosulfato de sodio tópico, y evidenciar el impacto positivo en la tasa de filtrado glomerular (TFG) tras la cicatrización de las heridas. Método: el paciente presentó dos úlceras en la cara posterior de la pierna derecha, que surgen tras una hospitalización por insuficiencia cardíaca congestiva. Se implementó una estrategia integral con la participación de infectología, nefrología y dermatología, que incluyó antibióticos intravenosos, control del dolor, cambio a anticoagulantes de nueva generación y aplicación de una pomada con tiosulfato de sodio para el cuidado local. Resultados: a los siete meses se logró la cicatrización completa de las lesiones y una mejoría significativa de la tasa de filtrado glomerular, confirmada por tres mediciones consecutivas de parámetros de filtrado renal. El tiosulfato de sodio tópico desempeñó un papel clave en la cicatrización, lo que respalda su potencial como opción terapéutica en calcifilaxis. Conclusión: este caso resalta la importancia del manejo interdisciplinario en la arteriolopatía calcificante, abordando tanto las causas subyacentes como el tratamiento local. La resolución de las lesiones y la mejoría de la función renal sugieren que el tiosulfato de sodio tópico puede ser una alternativa valiosa, especialmente cuando el tratamiento sistémico resulta complejo. Este reporte aporta evidencia a la escasa literatura sobre su uso tópico en calcifilaxis y refuerza la necesidad de un cuidado integral en estos pacientes.spa
dc.format.mimetypepdf
dc.identifier.citationBertarini MF, Belatti AL, Musso CG, Aroca-Martinez G, Bohmer LV, Enz PA, et al. Case report of successful comprehensive approach for calciphylaxis ulcers in a patient with renal failure, using topical sodium thiosulfate ointment. Rev. Colomb. Nefrol. 2025; 12(3), e787. https://doi.org/10.22265/acnef.12.3.787eng
dc.identifier.doihttps://doi.org/10.22265/acnef.12.3.787
dc.identifier.issn25005006 (electrónico)
dc.identifier.issn23897708 (impreso)
dc.identifier.urihttps://hdl.handle.net/20.500.12442/16991
dc.identifier.urlhttps://revistanefrologia.org/index.php/rcn/article/view/787
dc.language.isoeng
dc.publisherAsociación Colombiana de Nefrología e Hipertensión Arterialspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceRevista Colombiana de Nefrologíaspa
dc.sourceVol. 12, Núm. 3 (2025)spa
dc.subjectCalcifilaxisspa
dc.subjectTiosulfato de sodiospa
dc.subjectEnfermedad renal crónicaspa
dc.subjectManejo multidisciplinariospa
dc.subjectHerida crónicaspa
dc.subjectTasa de filtrado glomerularspa
dc.subject.keywordsCalciphylaxiseng
dc.subject.keywordsSodium thiosulfateeng
dc.subject.keywordsChronic kidney diseaseeng
dc.subject.keywordsMultidisciplinary managementeng
dc.subject.keywordsChronic woundeng
dc.subject.keywordsGlomerular filtration rateeng
dc.titleComprehensive approach to skin ulcers caused by calciphylaxis in a patient with chronic renal failure, treated with topical sodium thiosulfate ointment: A case reporteng
dc.title.translatedAbordaje integral de úlceras cutáneas por calcifilaxis en paciente con insuficiencia renal crónica, tratadas con pomada tópica de tiosulfato de sodio: un reporte de casospa
dc.type.driverinfo:eu-repo/semantics/article
dc.type.spaArtículo científico
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