Análisis molecular y filogenético de SARS-CoV-2 presente en Colombia
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Fecha
2022
Autores
Rivera Roca, Sirly Johanna
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Ediciones Universidad Simón Bolivar
Facultad de Ciencias Básicas y Biomédicas
Facultad de Ciencias Básicas y Biomédicas
Resumen
l SARS-CoV-2 es un virus que constituye una importante amenaza para la salud a nivel mundial, debido a las altas tasas de infección y mortalidad que presenta.
Pese a esto sus rasgos genéticos y los procesos evolutivos a los que está sometido aún son desconocido y es poca la información que existe en nuestro país. Para poder entender los procesos evolutivos a los que está sometido este nuevo virus, es importante obtener una filogenia de las diferentes variantes circulantes, analizar esta variabilidad entre otras características, tanto en nuestro
territorio como en el mundo. En esta investigación, se realizó un análisis bioinformático de los genes de
importancia estructural y funcional del virus, determinando de esta forma características genómicas y filogenéticas, de los subtipos de SARS-CoV-2
circulantes, mediante el método de inferencia bayesiana, adicionalmente se exploraron las relaciones entre las proteínas de algunas cepas y el grado de
conservación total de la proteína E en todos los continentes.
SARS-CoV-2 is a virus that has caused major health threats in the world. The genetic traits and evolutionary processes of each of its proteins in Colombia are still largely unknown. In order to have more information on their phylogeny, variability or evolutionary mutability, in the strains that circulate in Colombia, in relation to the strains of the world, a bioinformatic analysis of the genes that translate to structural and accessory proteins was carried out, determining in this way genomic and phylogenetic characteristics of the circulating SARS-CoV-2 subtypes, through Bayesian inference methods and thus be participants in the construction of important bases, for the advancement of new diagnostic and treatment methods, finding relationships between the proteins of some strains and the total conservation of protein E in all continents.
SARS-CoV-2 is a virus that has caused major health threats in the world. The genetic traits and evolutionary processes of each of its proteins in Colombia are still largely unknown. In order to have more information on their phylogeny, variability or evolutionary mutability, in the strains that circulate in Colombia, in relation to the strains of the world, a bioinformatic analysis of the genes that translate to structural and accessory proteins was carried out, determining in this way genomic and phylogenetic characteristics of the circulating SARS-CoV-2 subtypes, through Bayesian inference methods and thus be participants in the construction of important bases, for the advancement of new diagnostic and treatment methods, finding relationships between the proteins of some strains and the total conservation of protein E in all continents.
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Palabras clave
Evolución, Filogenética, Variabilidad, Genoma, Mutabilidad, Evolution, Phylogenetics, Variability, Genome, Mutability