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Análisis molecular y filogenético de SARS-CoV-2 presente en Colombia

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datacite.rightshttp://purl.org/coar/access_right/c_16eceng
dc.contributor.advisorArquéz Mendoza, Moisés Alberto
dc.contributor.advisorLozano Solano, Dayan
dc.contributor.authorRivera Roca, Sirly Johanna
dc.date.accessioned2022-02-14T20:40:23Z
dc.date.available2022-02-14T20:40:23Z
dc.date.issued2022
dc.description.abstractl SARS-CoV-2 es un virus que constituye una importante amenaza para la salud a nivel mundial, debido a las altas tasas de infección y mortalidad que presenta. Pese a esto sus rasgos genéticos y los procesos evolutivos a los que está sometido aún son desconocido y es poca la información que existe en nuestro país. Para poder entender los procesos evolutivos a los que está sometido este nuevo virus, es importante obtener una filogenia de las diferentes variantes circulantes, analizar esta variabilidad entre otras características, tanto en nuestro territorio como en el mundo. En esta investigación, se realizó un análisis bioinformático de los genes de importancia estructural y funcional del virus, determinando de esta forma características genómicas y filogenéticas, de los subtipos de SARS-CoV-2 circulantes, mediante el método de inferencia bayesiana, adicionalmente se exploraron las relaciones entre las proteínas de algunas cepas y el grado de conservación total de la proteína E en todos los continentes.spa
dc.description.abstractSARS-CoV-2 is a virus that has caused major health threats in the world. The genetic traits and evolutionary processes of each of its proteins in Colombia are still largely unknown. In order to have more information on their phylogeny, variability or evolutionary mutability, in the strains that circulate in Colombia, in relation to the strains of the world, a bioinformatic analysis of the genes that translate to structural and accessory proteins was carried out, determining in this way genomic and phylogenetic characteristics of the circulating SARS-CoV-2 subtypes, through Bayesian inference methods and thus be participants in the construction of important bases, for the advancement of new diagnostic and treatment methods, finding relationships between the proteins of some strains and the total conservation of protein E in all continents.e
dc.format.mimetypepdfspa
dc.identifier.urihttps://hdl.handle.net/20.500.12442/9364
dc.language.isospaspa
dc.publisherEdiciones Universidad Simón Bolivarspa
dc.publisherFacultad de Ciencias Básicas y Biomédicasspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEvoluciónspa
dc.subjectFilogenéticaspa
dc.subjectVariabilidadspa
dc.subjectGenomaspa
dc.subjectMutabilidadspa
dc.subjectEvolutionspa
dc.subjectPhylogeneticseng
dc.subjectVariabilityeng
dc.subjectGenomeeng
dc.subjectMutabilityeng
dc.titleAnálisis molecular y filogenético de SARS-CoV-2 presente en Colombiaspa
dc.type.driverinfo:eu-repo/semantics/masterThesiseng
dc.type.spaTrabajo de grado másterspa
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oaire.versioninfo:eu-repo/semantics/acceptedVersioneng
sb.programaMaestría en Genéticaspa
sb.sedeSede Barranquillaspa

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