Biomarcadores moleculares en sepsis: revisión sistemática
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Fecha
2018
Autores
Fruto Maldonado, Jennifer
Velasquez, Luz Adriana
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Editor
Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
Antecedentes: La sepsis es una condición común que se asocia con una mortalidad inaceptablemente alta, para muchos de los que sobreviven, morbilidad a largo plazo. La Asamblea Mundial de la Salud y la OMS hicieron de la sepsis una prioridad mundial de salud en 2017 y han adoptado medidas para mejorar la prevención, el diagnóstico y el tratamiento, el uso de biomarcadores predictores de la evolución de sepsis al shock séptico y por ende la mortalidad alta que conlleva este último.
Objetivos: Describir el estado del arte de los biomarcadores moleculares propuestos para el diagnóstico y pronóstico de sepsis, sepsis grave y choque séptico, mediante la revisión sistemática de bases de datos en el periodo de 2014-2018.
Materiales y Métodos: Articulo de revisión en la que se analizaron los registros de los últimos 5 años (2014-2018) que se encontraban en las bases de datos:
MEDLINE (NML) PubMed. Clasificados por año de publicación e incluyendo solo artículos de investigación y de revisión que evaluaran o trataran las Palabras clave: “Presepsin”, “Biomarcadores”, “Sepsis”, “Shock séptico”.
Resultados: Para la revisión se tuvieron en cuenta 32 artículos caracterizados por ser publicados en el periodo comprendido entre 2014 y 2018, los cuales describieron aspectos teóricos de la Presipsina CD14 soluble en relación con otros biomarcadores moleculares existentes actualmente con valores diagnósticos para el desarrollo de sepsis y choque séptico.
Background: Sepsis is a common condition that is associated with unacceptably high mortality, for many of those who survive, long-term morbidity. The World Health Assembly and WHO made sepsis a global health priority in 2017 and have adopted measures to improve prevention, diagnosis and treatment, the use of predictive biomarkers of the progression from sepsis to septic shock and for hence the high mortality associated with the latter. Objective: To describe the state of the art of the molecular biomarkers proposed for the diagnosis and prognosis of sepsis, severe sepsis and septic shock, through the systematic review of databases in the period 2014-2018. Materials and Methods: Review article in which the records of the last 5 years (2014-2018) that were in the databases were analyzed: MEDLINE (NML) PubMed. Classified by year of publication and including only research and review articles that evaluate or address the Keywords: "Presepsin", "Biomarkers", "Sepsis", "Septic shock". Results: For the review, 32 articles characterized by being published in the period between 2014 and 2018 were taken into account, which described theoretical aspects of soluble CD14 Presipsin in relation to other currently existing molecular biomarkers with diagnostic values for the development of sepsis and shock septic.
Background: Sepsis is a common condition that is associated with unacceptably high mortality, for many of those who survive, long-term morbidity. The World Health Assembly and WHO made sepsis a global health priority in 2017 and have adopted measures to improve prevention, diagnosis and treatment, the use of predictive biomarkers of the progression from sepsis to septic shock and for hence the high mortality associated with the latter. Objective: To describe the state of the art of the molecular biomarkers proposed for the diagnosis and prognosis of sepsis, severe sepsis and septic shock, through the systematic review of databases in the period 2014-2018. Materials and Methods: Review article in which the records of the last 5 years (2014-2018) that were in the databases were analyzed: MEDLINE (NML) PubMed. Classified by year of publication and including only research and review articles that evaluate or address the Keywords: "Presepsin", "Biomarkers", "Sepsis", "Septic shock". Results: For the review, 32 articles characterized by being published in the period between 2014 and 2018 were taken into account, which described theoretical aspects of soluble CD14 Presipsin in relation to other currently existing molecular biomarkers with diagnostic values for the development of sepsis and shock septic.
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Palabras clave
Presepsin, Soluble CD-14, Biomarkers, Sepsis, Septic Shock