Eficacia de una crema lipolítica en un tratamiento de sobrepeso y obesidad
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Fecha
2019
Autores
Kalmar, Isaac
Cortés-Castell, Ernesto
Rizo-Baeza, Mercedes
Consuegra, José Rafael
Jiménez-Cabas, Javier
Título de la revista
ISSN de la revista
Título del volumen
Editor
Sociedad Venezolana de Farmacología Clínica y Terapéutica
Resumen
Objetivo. Evaluar la eficacia coadyuvante de una combinación
de ingredientes cosméticos en forma de crema lipolítica
con dieta hipocalórica y actividad física comparada con dieta
hipocalórica y actividad física para el tratamiento del sobrepeso
y la obesidad en pacientes.
Material y métodos. Se realizó un estudio monocéntrico,
abierto y aleatorizado de grupos paralelos de 102 pacientes
que consultaron a un centro de nutrición médico-clínico para
el tratamiento del sobrepeso y la obesidad. Los perímetros
de altura, brazo, cintura, cadera y muslo y el análisis de la
composición corporal segmentaria con un equipo de impedancia
se estudiaron en pacientes de 18 a 99 años de ambos
sexos con asistencia voluntaria y con presencia de sobrepeso
u obesidad durante un período de 16 semanas consecutivas.
Los datos se analizaron estadísticamente comparando
los valores iniciales y finales de todos los valores en ambos
grupos. La seguridad fue monitoreada por la incidencia de
eventos adversos. Un valor de p<0,001 fue considerado
como de significación estadística.
Resultados. Del total de 102 pacientes, se aplicaron los criterios
de inclusión y exclusión; se incluyeron y analizaron 45
y 47 casos, respectivamente. La edad oscila entre 39,16 y
42,09 años (p = 0,246); el peso inicial 85,9 kg vs 85,08 kg
(p = 0,810); perímetros: cintura inicial de 100,4 cm frente a
99,7 cm (p = 0,826); brazo inicial de 32,9 cm vs 33,4 cm (p =
0,453); cadera inicial: 108,6cm vs 107,7 (p = 0,666). Peso final
82,6 kg vs 78,7 kg (p = 0,227); perímetros: cintura final de
94,9 cm frente a 90,9 cm (p = 0,144); brazo final de 31,8 cm
frente a 31,4 cm (p = 0,453); Cadera final: 106,7 cm vs 102,1
(p = 0,074). No hubo ningún informe de efectos secundarios
no deseados con el uso de crema lipolítica, presentando
una buena aceptabilidad. Los pacientes con crema lipolítica
como adyuvante en el tratamiento del sobrepeso u obesidad
perdieron mayor IMC, mayor porcentaje de peso y mayor
porcentaje de grasa (p<0,001).
Objective. To evaluate the coadyouvant efficacy of a combination of cosmetics ingredients in the form of a lipolytic cream with hypocaloric diet and physical activity and compared with hypocaloric diet and physical activity for overweight and obesity treatment in patients. Material and methods. It was conducted a monocentric, open-label, randomized study of parallel groups of 102 patients that consulted in a medical-clinical nutrition center for overweight and obesity treatment. Height, arm, waist, hip and thigh perimeters and the analysis of segmental body composition with an impedance team were studied in patients between 18 and 99 years, of both sexes with voluntary attendance and with presence of overweight or obesity during a period of 16 consecutive weeks. The data were statistically analyzed by comparing the initial and final values of all the values in both groups. Safety was monitored by the incidence of adverse events. A value of p<0.001 was considered as statistical significance. Results. Of the total of 102 patients, the inclusion and exclusion criteria were applied; 45 and 47 cases are included and analyzed respectively. The age ranges between 39.16 vs 42.09 years (p = 0.246); initial weight 85.9 kg vs 85.08 kg (p = 0.810); perimeters: initial waist of 100.4cm vs 99.7cm (p = 0.826); initial arm of 32.9cm vs 33.4cm (p = 0.453); initial hip: 108.6cm vs 107.7 (p = 0.666). Final weight 82.6 kg vs 78.7 kg (p = 0.227); perimeters: final waist of 94.9 cm vs 90.9 cm (p = 0.144); final arm of 31.8 cm vs 31.4 cm (p = 0.453); final hip: 106.7 cm vs 102, 1 (p = 0.074). There was no report of unwanted side effects with the use of lipolytic cream, presented good acceptability. Patients with lipolytic cream as adjuvant in the treatment of overweight or obesity lose greater BMI, greater percentage of weight and greater percentage of fat (p <0.001). Conclusion. Patients with lipolytic cream as adjuvant in the treatment of overweight or obesity lose greater BMI, greater percentage of weight and greater percentage of fat.
Objective. To evaluate the coadyouvant efficacy of a combination of cosmetics ingredients in the form of a lipolytic cream with hypocaloric diet and physical activity and compared with hypocaloric diet and physical activity for overweight and obesity treatment in patients. Material and methods. It was conducted a monocentric, open-label, randomized study of parallel groups of 102 patients that consulted in a medical-clinical nutrition center for overweight and obesity treatment. Height, arm, waist, hip and thigh perimeters and the analysis of segmental body composition with an impedance team were studied in patients between 18 and 99 years, of both sexes with voluntary attendance and with presence of overweight or obesity during a period of 16 consecutive weeks. The data were statistically analyzed by comparing the initial and final values of all the values in both groups. Safety was monitored by the incidence of adverse events. A value of p<0.001 was considered as statistical significance. Results. Of the total of 102 patients, the inclusion and exclusion criteria were applied; 45 and 47 cases are included and analyzed respectively. The age ranges between 39.16 vs 42.09 years (p = 0.246); initial weight 85.9 kg vs 85.08 kg (p = 0.810); perimeters: initial waist of 100.4cm vs 99.7cm (p = 0.826); initial arm of 32.9cm vs 33.4cm (p = 0.453); initial hip: 108.6cm vs 107.7 (p = 0.666). Final weight 82.6 kg vs 78.7 kg (p = 0.227); perimeters: final waist of 94.9 cm vs 90.9 cm (p = 0.144); final arm of 31.8 cm vs 31.4 cm (p = 0.453); final hip: 106.7 cm vs 102, 1 (p = 0.074). There was no report of unwanted side effects with the use of lipolytic cream, presented good acceptability. Patients with lipolytic cream as adjuvant in the treatment of overweight or obesity lose greater BMI, greater percentage of weight and greater percentage of fat (p <0.001). Conclusion. Patients with lipolytic cream as adjuvant in the treatment of overweight or obesity lose greater BMI, greater percentage of weight and greater percentage of fat.
Descripción
Palabras clave
Lipólisis, Crema para la piel, Obesidad, Sobrepeso, Lipolysis, Skin cream, Obesity, Overweight