La velocidad de onda de pulso y el envejecimiento arterial en sujetos con y sin diabetes mellitus tipo 2
Cargando...
Fecha
2018
Autores
Buelvas-Herazo, Jannes
Urina-Triana, Miguel
Mantilla- Morrón, Mirary
Urina-Jassir, Daniela
Galeano-Muñoz, Luisa
Urina-Triana, Manuel
Quintero-Baiz, Adalberto
Título de la revista
ISSN de la revista
Título del volumen
Editor
Cooperativa servicios y suministros 212518 RS
Resumen
Introducción y Objetivos: La velocidad de onda de pulso
(VOP) es un procedimiento para evaluar la rigidez arterial
con utilidad pronostica cardiovascular. En este estudio
comparamos la VOP entre sujetos con y sin Diabetes Mellitus
tipo 2 (DM2) para conocer sus diferencias y cuáles son
los factores que las ocasionan.
Métodos y Materiales: Estudio de cohorte en 39 sujetos
(12 con DM2 y 27 sin DM2). Después de reposo de 15 minutos,
se midió en la arteria braquial en forma oscilométrica
la VOP mediante dispositivo Mobil-O-Graph, y con
dos tomas consecutivas se obtuvo el promedio. El valor
obtenido se comparó contra los valores normales esperados
de referencia de acuerdo con la edad. Se calculó la
edad arterial aproximada. Se utilizó SPSS para Mac versión
24 para hacer los análisis y se consideró significancia estadística
a una p<0.05.
Resultados: Los sujetos con DM2 tuvieron mayor VOP
que los sujetos sin DM2 (p=0.02); a mayor tiempo de
evolución de la DM2 mayor fue la VOP (p=0.01). La correlación
bivariada bilateral (correlación de Pearson) entre
edad cronológica y edad arterial aproximada calculada
por el Mobil-O-Graph fue 0,957 (p=0.00) y entre la VOP y
la edad cronológica fue de 0,914 (p=0,000).
Conclusiones: La VOP aumentada está relacionada con
el tiempo de evolución de la DM2 y existió correlación positiva
con la edad cronológica. Más estudios se necesitan
para definir valores de referencia y de normalidad del VOP
y debería ser una herramienta de evaluación cardiovascular
en el sujeto con DM2.
Introduction and Objectives: Pulse wave velocity (PWV) is a measure of arterial stiffness which has been used to determine cardiovascular prognosis. In this study, we compared PWV between patients with and without Diabetes Mellitus type 2 (DM2) in order to identify their differences and associated factors. Methods and Materials: This was a cohort study where 39 subjects were enrolled (12 with DM2 and 27 without DM2). PWV was measured in the brachial artery through oscillometry using a Mobil-O-Graph device after 15 minutes of rest. An average value was obtained from two consecutive measurements. We compared this measurement with the normal expected values of reference according to patient’s age. The approximate arterial age was also calculated. SPSS for Mac version 24 was used to make the analyzes and statistical significance was considered a p value <0.05. Results: Subjects with DM2 had higher PWV than subjects without DM2 (p = 0.02). Additionally, the longer time with DM2 a higher PWV was seen (p = 0.01). Bilateral bivariate correlation (Pearson correlation) between chronological age and approximate arterial age was 0.957 (p = 0.00) whereas between PWV and chronological age was 0.914 (p = 0.000). Conclusions: We concluded that higher levels of PWV are correlated to the time of evolution of DM2. PWV has also a positive correlation with chronological age. More studies with bigger populations are yet needed to determine reference and normal values of PWV, as it may be used as a tool for cardiovascular assessment in patients with DM2.
Introduction and Objectives: Pulse wave velocity (PWV) is a measure of arterial stiffness which has been used to determine cardiovascular prognosis. In this study, we compared PWV between patients with and without Diabetes Mellitus type 2 (DM2) in order to identify their differences and associated factors. Methods and Materials: This was a cohort study where 39 subjects were enrolled (12 with DM2 and 27 without DM2). PWV was measured in the brachial artery through oscillometry using a Mobil-O-Graph device after 15 minutes of rest. An average value was obtained from two consecutive measurements. We compared this measurement with the normal expected values of reference according to patient’s age. The approximate arterial age was also calculated. SPSS for Mac version 24 was used to make the analyzes and statistical significance was considered a p value <0.05. Results: Subjects with DM2 had higher PWV than subjects without DM2 (p = 0.02). Additionally, the longer time with DM2 a higher PWV was seen (p = 0.01). Bilateral bivariate correlation (Pearson correlation) between chronological age and approximate arterial age was 0.957 (p = 0.00) whereas between PWV and chronological age was 0.914 (p = 0.000). Conclusions: We concluded that higher levels of PWV are correlated to the time of evolution of DM2. PWV has also a positive correlation with chronological age. More studies with bigger populations are yet needed to determine reference and normal values of PWV, as it may be used as a tool for cardiovascular assessment in patients with DM2.
Descripción
Palabras clave
Rigidez vascular, Diabetes Mellitus, Velocidad de onda de pulso, Vascular rigidity, Diabetes Mellitus, Pulse wave velocity