Features of Dengue and Chikungunya Infections of Colombian Children under 24 Months of Age Admitted to the Emergency Department
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Fecha
2017
Autores
Paternina-Caicedo, Angel
De la Hoz-Restrepo, Fernando
Díaz-Quijano, Fredi
Caicedo-Torres, William
Badillo-Viloria, María Auxiliadora
Bula-Anichiarico, Doris
Alvis-Guzmán, Nelson
Mattar, Salim
Constenla, Dagna
Pinzón-Redondo, Hernando
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Editor
Oxford University Press
Resumen
We aimed to assess clinical and laboratory differences between dengue and chikungunya in children
<24 months of age in a comparative study. We collected retrospective clinical and laboratory data
confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective
data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months
(22 September 2014–14 December 2014). Sensitivity and specificity [with 95% confidence interval
(CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency
admission best characterized dengue, with a sensitivity of 67% (95% CI, 53–79) and specificity of
95% (95% CI, 82–99). The algorithm developed with classification and regression tree analysis
showed a sensitivity of 93% (95% CI, 68–100) and specificity of 38% (95% CI, 9–76) to diagnose
dengue. Our study provides potential differential characteristics between chikungunya and dengue
in young children, especially low platelet counts.
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Palabras clave
Dengue, Chikungunya, Severe dengue, Complications, Children