Features of Dengue and Chikungunya Infections of Colombian Children under 24 Months of Age Admitted to the Emergency Department

dc.contributor.authorPaternina-Caicedo, Angel
dc.contributor.authorDe la Hoz-Restrepo, Fernando
dc.contributor.authorDíaz-Quijano, Fredi
dc.contributor.authorCaicedo-Torres, William
dc.contributor.authorBadillo-Viloria, María Auxiliadora
dc.contributor.authorBula-Anichiarico, Doris
dc.contributor.authorAlvis-Guzmán, Nelson
dc.contributor.authorMattar, Salim
dc.contributor.authorConstenla, Dagna
dc.contributor.authorPinzón-Redondo, Hernando
dc.description.abstractWe aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014–14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53–79) and specificity of 95% (95% CI, 82–99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68–100) and specificity of 38% (95% CI, 9–76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts.eng
dc.publisherOxford University Presseng
dc.rights.licenseLicencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalspa
dc.sourceJournal of Tropical Pediatricseng
dc.sourceVol. 64, No. 1 (2018)spa
dc.subjectSevere dengueeng
dc.titleFeatures of Dengue and Chikungunya Infections of Colombian Children under 24 Months of Age Admitted to the Emergency Departmenteng
dcterms.referencesFuruya-Kanamori L, Liang S, Milinovich G, et al. Codistribution and co-infection of chikungunya and dengue viruses. BMC Infect Dis 2016;16:84. [cited 12 December 2016] http://www.ncbi.nlm.nih.gov/pubmed/26936191.eng
dcterms.referencesBhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue. Nature 2013;496:504–7. [cited 12 December 2016] http://www.ncbi.nlm.nih.gov/pubm ed/23563266.eng
dcterms.referencesMattar S, Miranda J, Pinzon H, et al. Outbreak of chikungunya virus in the North Caribbean area of Colombia: clinical presentation and phylogenetic analysis. J Infect Dev Ctries 2015;9:1126–32. [cited 12 December 2016] http:// www.jidc.org/index.php/journal/article/view/6670.eng
dcterms.referencesPinzón-Redondo H, Paternina-Caicedo A, Barrios-Redondo K, et al. Risk Factors for Severity of Chikungunya in Children: A Prospective Assessment. Pediatr Infect Dis J 2016;35:702–4. [cited 12 December 2016] http://content. wkhealth.com/linkback/openurl?sid¼WKPTLP:landingpage &an¼00006454-201606000-00024.eng
dcterms.referencesFullerton LM, Dickin SK, Schuster-Wallace CJ. Mapping global vulnerability to dengue using the water associated disease index, 2012. Hamilton, Canada: United Nations University.eng
dcterms.referencesInstituto Nacional de Salud. Comportamiento de los eventos de vigilancia en salud p ublica. Boletin Epidemiologico Semana. 2014, 17–19. [cited 12 December 2016] http:// www.ins.gov.co/boletin-epidemiologico/Boletn Epidemiol gico/2014 Boletin epidemiologico semana 53.pdf.spa
dcterms.referencesPinzón-Redondo H, Paternina-Caicedo A, Alvis-Guzman N, et al. Performance of two World Health Organization Dengue classifications in a pediatric cohort from Colombia. Value Heal 2015;18:A248–9. [cited 12 December 2016] http://linkinghub.elsevier.com/retrieve/pii/S10983015150 15041.eng
dcterms.referencesWorld Bank Group. 2016. [cited 1 May 2016] http:// www.worldbank.org/.eng
dcterms.referencesOviedo M, Mendez N, Mattar S, et al. Epidemic outbreak of chikungunya in two neighboring towns in the Colombian Caribbean: a survival analysis. Arch Public Heal 2017;75:1.eng
dcterms.referencesVillamil-Gómez W, Alba-Silvera L, Menco-Ramos A, et al. Congenital chikungunya virus infection in Sincelejo, Colombia: a case series. J Trop Pediatr 2015;61:386–92. [cited 12 December 2016] http://www.ncbi.nlm.nih.gov/ pubmed/26246086.eng
dcterms.referencesKliegman R, Nelson WE. Nelson Textbook of Pediatrics. 19th edn. Philadelphia, PA: Elsevier/Saunders, 2011, 2610.eng


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