Examinando por Autor "Cadena Bonfanti, Andres"
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Ítem Epigenetic mechanisms and posttranslational modifications in systemic Lupus Erythematosus(Multidisciplinary Digital Publishing Institute (MDPI), 2019) Navarro Quiroz, Elkin; Chavez-Estrada, Valeria; Macias-Ochoa, Karime; Ayala-Navarro, María Fernanda; Flores-Aguilar, Aniyensy Sarai; Morales-Navarrete, Francisco; De la Cruz Lopez, Fernando; Gomez Escorcia, Lorena; G. Musso, Carlos; Aroca Martinez, Gustavo; Gonzales Torres, Henry; Diaz Perez, Anderson; Cadena Bonfanti, Andres; Sarmiento Gutierrez, Joany; Meza, Jainy; Diaz Arroyo, Esperanza; Bello Lemus, Yesit; Ahmad, Mostapha; Navarro Quiroz, RobertoThe complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.Ítem Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus(Public Library of Science, 2019) Navarro Quiroz, Elkin; Navarro Quiroz, Roberto; Pacheco Lugo, Lisandro; Aroca Martínez, Gustavo; Gómez Escorcia, Lorena; Gonzalez Torres, Henry; Cadena Bonfanti, Andres; Marmolejo, Maria del Carmen; Sanchez, Eduardo; Villarreal Camacho, Jose Luis; Lorenzi, Hernan; Torres, Augusto; Navarro, Kelvin Fernando; Navarro Rodriguez, Pablo; Villa, Joe Luis; Fernández- Ponce, CeciliaThe aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone modifications in systemic lupus erythematosus (SLE). To identify miRNA dysregulation in SLE, we used miR2Disease and PhenomiR for information about miRNAs exhibiting differential regulation in disease and other biological processes, and HMDD for information about experimentally supported human miRNA–disease association data from genetics, epigenetics, circulating miRNAs, and miRNA–target interactions. This information was incorporated into the miRNA analysis. High-throughput sequencing revealed circulating miRNAs associated with kidney damage in patients with SLE. As the main finding of our in silico analysis of miRNAs differentially expressed in SLE and their interactions with disease-susceptibility genes, post-translational modifications, and transcription factors; we highlight 226 miRNAs associated with genes and processes. Moreover, we highlight that alterations of miRNAs such as hsa-miR-30a-5p, hsa-miR-16-5p, hsa-miR-142-5p, and hsa-miR-324-3p are most commonly associated with post-translational modifications. In addition, altered miRNAs that are most frequently associated with susceptibility-related genes are hsa-miR-16-5p, hsamiR- 374a-5p, hsa-miR-34a-5p, hsa-miR-31-5p, and hsa-miR-1-3p.