Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.contributor.author | Musso, Carlos | |
| dc.contributor.author | Juarez, Rossina | |
| dc.contributor.author | González-Torres, Henry Joseth | |
| dc.contributor.author | Capotondo, Mercedes | |
| dc.contributor.author | Terrasa, Sergio | |
| dc.contributor.author | Aroca-Martinez, Gustavo | |
| dc.date.accessioned | 2026-02-13T15:07:30Z | |
| dc.date.available | 2026-02-13T15:07:30Z | |
| dc.date.issued | 2026 | |
| dc.description.abstract | Context: Renal functional reserve (RFR) refers to the kidney’s capability to increase its basal glomerular filtration rate (GFR) by at least 20 % after an adequate stimulus, such as a protein overload. As far as we know, no studies have yet reported the behavior of electrolyte excretion during the renal functional reserve test. Material and methods: A prospective study to evaluate serum and urinary changes in electrolytes, nitrogenous waste products, glucose, protein, and albumin during the renal functional reserve test in healthy young adults, evaluating their cimetidine-aided creatinine clearance and renal functional reserve test (Hellerstein). Results: There was a statistically significant increase in glomerular filtration rate (positive renal functional reserve) and serum glucose, as well as a significant reduction in serum values of nitrogen derivatives and electrolytes in 46 healthy young adult volunteers during the renal functional reserve test. Regarding the urinary fractional excretion of these substances, significant increases were observed for nitrogenous waste products and electrolytes, except for phosphorus, glucose, protein, and albumin urinary excretion, which suffered no change. Conclusion: The renal functional reserve significantly modified not only glomerular filtration rate but also nitrogenous waste products and electrolyte serum levels, as well as their urinary fractional excretion values in healthy young adults (mean age: 35 years). | spa |
| dc.description.abstract | Contexto: la reserva funcional renal (RFR) es la capacidad del riñón para aumentar su tasa de filtración glomerular basal (TFG) hasta al menos un 20 % tras un estímulo adecuado, como una sobrecarga proteica. Hasta donde sabemos, aún no se ha descrito qué ocurre con la excreción de electrolitos durante la prueba de reserva funcional renal. Material y métodos: estudio prospectivo para evaluar los cambios en los electrolitos séricos y urinarios, productos de desecho nitrogenados, glucosa, proteínas y albúmina durante la prueba de reserva funcional renal en adultos jóvenes sanos, evaluando su aclaramiento de creatinina con cimetidina y la prueba de reserva funcional renal (Hellerstein). Resultados: se observó un aumento estadísticamente significativo de la tasa de filtración glomerular (reserva funcional renal positiva) y de la glucosa sérica, así como una reducción significativa de los valores séricos de derivados nitrogenados y electrolitos en 46 voluntarios adultos jóvenes sanos durante la prueba de reserva funcional renal. En cuanto a la excreción fraccional urinaria de estas sustancias, se observó un aumento significativo de los productos de desecho nitrogenados y de los electrolitos, con excepción de la excreción urinaria del fósforo, la glucosa, las proteínas y la albúmina, la cual no presentó cambios. Conclusión: la reserva renal modificó significativamente no solo la tasa de filtración glomerular, sino también los niveles séricos de los productos de desecho nitrogenados y de los electrolitos, así como sus valores de excreción fraccional urinaria, en adultos jóvenes sanos (edad media: 35 años). | eng |
| dc.format.mimetype | ||
| dc.identifier.citation | Musso CG, Juarez R, Gonzalez-Torres H, Capotondo M, Terrasa S, Aroca-Martinez G. Serum and urine electrolyte and nitrogenous waste product changes during the renal functio- nal reserve test. Rev. Colomb. Nefrol. 2026; 13(1), e818. https://doi.org/10.22265/acnef.13.1.818 | |
| dc.identifier.doi | http://doi.org/10.22265/acnef.13.1.818 | |
| dc.identifier.issn | 2500-5006 (Electrónico) | |
| dc.identifier.issn | 2389-7708 (Impreso) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/17357 | |
| dc.identifier.url | https://revistanefrologia.org/index.php/rcn/article/view/818/1282 | |
| dc.language.iso | eng | |
| dc.publisher | Asociación Colombiana de Nefrología e Hipertensión Arterial | spa |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Revista Colombiana de Nefrología | spa |
| dc.source | Rev. Colomb. Nefrol. | spa |
| dc.source | Vol. 13 No. 1 Año 2026 | spa |
| dc.subject | Reserva renal | spa |
| dc.subject | Electrolitos | spa |
| dc.subject | Fisiología renal | spa |
| dc.subject | Riñón | spa |
| dc.subject | Tasa de filtración glomerular | spa |
| dc.subject | Estudios prospectivos | spa |
| dc.subject.keywords | Renal reserve | eng |
| dc.subject.keywords | Electrolytes | eng |
| dc.subject.keywords | Renal physiology | eng |
| dc.subject.keywords | Kidney | eng |
| dc.subject.keywords | Glomerular filtration rate | eng |
| dc.subject.keywords | Prospective studies | eng |
| dc.title | Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test | eng |
| dc.title.translated | Cambios en los electrolitos séricos y urinarios y en los productos de desecho nitrogenados durante la prueba de reserva funcional renal | spa |
| dc.type.driver | info:eu-repo/semantics/article | |
| dc.type.spa | Artículo científico | |
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| oaire.version | info:eu-repo/semantics/publishedVersion | |
| sb.sede | Sede Barranquilla | spa |