Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community: In search of shared genetic markers
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.contributor.author | Garavito-De Egea, Gloria | |
| dc.contributor.author | Domínguez-Vargas, Alex | |
| dc.contributor.author | Vélez, Jorge I. | |
| dc.contributor.author | Aroca, Gustavo | |
| dc.contributor.author | Fang, Luis | |
| dc.contributor.author | Navarro-Quiroz, Elkin | |
| dc.contributor.author | Espitaleta, Zilac | |
| dc.contributor.author | Del Toro-Camargo, Kenny | |
| dc.contributor.author | Martínez-Ariza, Leticia | |
| dc.contributor.author | González-Vargas, Tatiana | |
| dc.contributor.author | García, Susana | |
| dc.contributor.author | Arcos-Burgos, Mauricio | |
| dc.date.accessioned | 2024-05-30T19:48:12Z | |
| dc.date.available | 2024-05-30T19:48:12Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | In summary, our study outlines oligogenic common variation underpinning the susceptibility to develop T1D. These genetic polymorphisms are also shared by patients suffering from other diseases such as LN and JIA, indicating that the shared genetic architecture defined by pleiotropy and epistasis shapes the genetic susceptibility of these disorders in this multiethnic population. Given the predicted functional nature of these genetic variants, it is very likely that in this understudied multiethnic population, genes harboring these mutations are major contributors to AID immunopathology and provide new insights into the autoimmune tautology in this group of diseases. | eng |
| dc.format.mimetype | ||
| dc.identifier.doi | https://doi.org/10.1016/j.gendis.2023.06.027 | |
| dc.identifier.issn | 23523042 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/14702 | |
| dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2352304223003392?via%3Dihub | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
| dc.source | Genes & Diseases | eng |
| dc.source | Vol. 11 No. 4, (2024) | |
| dc.title | Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community: In search of shared genetic markers | eng |
| dc.type.driver | info:eu-repo/semantics/article | eng |
| dc.type.spa | Artículo científico | spa |
| dcterms.references | Lettre G, Rioux JD. Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet. 2008;17(R2): R116eR121. | eng |
| dcterms.references | Zhernakova A, van Diemen CC, Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet. 2009;10(1):43e55. | eng |
| dcterms.references | Cotsapas C, Voight BF, Rossin E, et al. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet. 2011;7(8): e1002254. | eng |
| dcterms.references | Caliskan M, Brown CD, Maranville JC. A catalog of GWAS finemapping efforts in autoimmune disease. Am J Hum Genet. 2021; 108(4):549e563. | eng |
| dcterms.references | Vélez JI, Lopera F, Silva CT, et al. Familial Alzheimer’s disease and recessive modifiers. Mol Neurobiol. 2020;57(2):1035e1043. | eng |
| oaire.version | info:eu-repo/semantics/publishedVersion | eng |