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Profiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritis

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dc.contributor.authorNavarro-Quiroz, Elkin
dc.contributor.authorPacheco-Lugo, Lisandro
dc.contributor.authorNavarro-Quiroz, Roberto
dc.contributor.authorLorenzi, Hernan
dc.contributor.authorEspaña-Puccini, Pierine
dc.contributor.authorDõÂaz-Olmos, Yirys
dc.contributor.authorAlmendrales, Lisneth
dc.contributor.authorOlave, Valeria
dc.contributor.authorGonzalez-Torres, Henry
dc.contributor.authorDiaz-Perez, Anderson
dc.contributor.authorDominguez, Alex
dc.contributor.authorIglesias, Antonio
dc.contributor.authorGarcía, Raul
dc.contributor.authorAroca-Martinez, Gustavo
dc.date.accessioned2018-02-05T20:25:44Z
dc.date.available2018-02-05T20:25:44Z
dc.date.issued2017-11-14
dc.description.abstractRenal involvement in Systemic Lupus Erythematous (SLE) patients is one of the leading causes of morbidity and a significant contributor to mortality. It's estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV) is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. The aim of this study was to evaluate the relative abundance of circulating microRNAs in peripheral blood from Colombian patients with LN-IV. Circulating miRNAs in plasma of patients with diagnosis of LN-IV were compared with individuals without renal involvement (LNN group) and healthy individuals (CTL group). Total RNA was extracted from 10 ml of venous blood and subsequently sequenced using Illumina. The sequences were processed and these were analyzed using miRBase and Ensembl databases. Differential gene expression analysis was carried out with edgeR and functional analysis were done with DIANA-miRPath. Analysis was carried out using as variables of selection fold change ( 2 o -2) and false discovery rate (0.05). We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR- 485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p). These changes in the abundance of miRNAs could be interpreted as alterations in the miRNAs-mRNA regulatory network in the pathogenesis of LN, preceding the clinical onset of the disease. The findings thus contribute to understanding the disease process and are likely to pave the way towards identifying disease biomarkers for early diagnosis of LN.spa
dc.identifier.issn19326203
dc.identifier.urihttp://hdl.handle.net/20.500.12442/1600
dc.language.isoengspa
dc.publisherXu-jie Zhou, Peking University First Hospital, CHINAeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenselicencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionaleng
dc.sourcePLOS ONEeng
dc.sourceVol. 12 (2017)
dc.source.urihttps://doi.org/10.1371/journal.
dc.subjectLupusspa
dc.titleProfiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritiseng
dc.typearticlespa
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