Microangiopatía trombótica: estudio histopatológico
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Fecha
2016
Autores
Ahumada, María José
Molina - Molina, Isamar
Rodríguez – Vizcaíno, Liliana
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
Antecedentes: La Microangiopatía trombótica se puede definir como una lesión estructural de la pared vascular. Esta entidad, se puede dividir en dos: síndrome hemolítico urémico y purpura trombocitopénica trombótica.
Objetivos: Describir a cada uno de los pacientes de consulta externa diagnosticados con Microangiopatía trombótica de la Clínica de la Costa de Barranquilla
Materiales y Métodos: Estudio de serie de casos entre los años 2007 – 2014. Se tomó una población total de 58 pacientes de la plataforma de Nefrored®, un Registro poblacional de enfermedad renal crónica de la Región caribe colombiana. Se tabuló la información en Microsoft Excel® 2010 de aquellos pacientes con inmunofluorescencia negativa, que en este caso el resultado es alrededor de 13.
Resultados: Dentro de los parámetros fuertemente asociados con la Microangiopatía trombótica se encontraron: Disminución de la hemoglobina y aumento tanto de la proteinuria y la hematuria.
Conclusiones: Se concluye que esta enfermedad es adquirida principalmente por el síndrome hemolítico urémico, principalmente por vía oro-fecal (contaminación de alimentos). Se ha encontrado que las pruebas realizadas solo 13 pacientes de 58 que padecían cualquiera de las glomerulopatías, son negativos para la inmunofluorescencia, muchos de estos pacientes a parte de presentar el síndrome urémico hemolítico, se asocian a diferentes nefropatías como IRC, síndromes nefróticos y nefríticos. Además, han tenido variaciones en valores como la disminución de la hemoglobina y aumento tanto de la proteinuria y la hematuria
Background: Thrombotic microangiopathy can be defined as a structural lesion of the vascular wall. This entity can be divided into two: haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura Objective: To describe each of the outpatients diagnosed with thrombotic microangiopathy Materials and Methods: A case series study was conducted between 2007 and 2014. A total population of 58 patients was taken from the Nefrored® platform, a population register of chronic kidney disease in the Colombian Caribbean Region. The information was tabulated in Microsoft Excel® 2010 of those patients with negative immunofluorescence, which in this case the result is around 13. Results: Among the parameters strongly associated with thrombotic microangiopathy were: Decreased hemoglobin and increased both proteinuria and hematuria. Conclusions: The disease is acquired mainly due to the haemolytic uraemic syndrome, mainly via oro-fecal route (food contamination). It has been found that the tests performed only 13 patients of 58 who suffered any of the glomerulopathies, are negative for immunofluorescence, many of these patients, apart from presenting haemolytic uremic syndrome, are associated with different nephropathies such as CRF, nephrotic and nephrotic syndromes. In addition, there have been variations in values such as decreased hemoglobin and increased both proteinuria and hematuria KeyWords: Thrombotic thrombocytopenic microangiopathy, haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura, hematuria, proteinuria, plasmapheresis.
Background: Thrombotic microangiopathy can be defined as a structural lesion of the vascular wall. This entity can be divided into two: haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura Objective: To describe each of the outpatients diagnosed with thrombotic microangiopathy Materials and Methods: A case series study was conducted between 2007 and 2014. A total population of 58 patients was taken from the Nefrored® platform, a population register of chronic kidney disease in the Colombian Caribbean Region. The information was tabulated in Microsoft Excel® 2010 of those patients with negative immunofluorescence, which in this case the result is around 13. Results: Among the parameters strongly associated with thrombotic microangiopathy were: Decreased hemoglobin and increased both proteinuria and hematuria. Conclusions: The disease is acquired mainly due to the haemolytic uraemic syndrome, mainly via oro-fecal route (food contamination). It has been found that the tests performed only 13 patients of 58 who suffered any of the glomerulopathies, are negative for immunofluorescence, many of these patients, apart from presenting haemolytic uremic syndrome, are associated with different nephropathies such as CRF, nephrotic and nephrotic syndromes. In addition, there have been variations in values such as decreased hemoglobin and increased both proteinuria and hematuria KeyWords: Thrombotic thrombocytopenic microangiopathy, haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura, hematuria, proteinuria, plasmapheresis.
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Microangiopatía trombótica trombocitopénica, Síndrome hemolítico urémico, Purpura trombocitopénica trombótica, Hematuria, Proteinuria, Plasmaféresis, Thrombotic thrombocytopenic microangiopathy, Haemolytic uraemic syndrome, Thrombotic thrombocytopenic purpura, Plasmapheresis