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Lamin A expression in circulating osteoprogenitors as a potential biomarker for frailty: The Nepean Osteoporosis and Frailty (NOF) Study

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dc.contributor.authorAl Saedi⁠, Ahmed
dc.contributor.authorGunawardene, Piumali
dc.contributor.authorBermeo, Sandra
dc.contributor.authorVogrin, Sara
dc.contributor.authorBoersma, Derek
dc.contributor.authorPhu, Steven
dc.contributor.authorSingh⁠, Lakshman
dc.contributor.authorSuriyaarachchi, Pushpa
dc.contributor.authorDuque, Gustavo
dc.date.accessioned2018-03-07T22:37:28Z
dc.date.available2018-03-07T22:37:28Z
dc.date.issued2018-02
dc.description.abstractLamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study. We quantified physical performance and disability, and stratified frailty in this population. Lamin A expression in epithelial and COP cells was quantified by flow cytometry. Linear regression models estimated the relationship between lamin A expression in buccal and COP cells, and prevalent disability and frailty. Lamin A expression in buccal cells showed no association with either disability or frailty. Low lamin A expression values in COP cells were associated with frailty. Frail individuals showed 60% lower levels of lamin A compared to non-frail (95% CI − 36 to − 74%, p < 0.001) and 62% lower levels compared to pre-frail (95%CI − 40 to − 76%, p < 0.001). In summary, we have identified lamin A expression in COP cells as a strong indicator of frailty. Further work is needed to understand lamin A expression as a risk stratifier, biomarker, or therapeutic target in frail older persons.eng
dc.identifier.issn05315565
dc.identifier.urihttp://hdl.handle.net/20.500.12442/1808
dc.language.isoengspa
dc.publisherElseviereng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseLicencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalspa
dc.sourceExperimental Gerontologyeng
dc.sourceVol. 102 (2018)eng
dc.source.urihttps://www.sciencedirect.com/science/article/pii/S0531556517307428?via%3Dihub
dc.subjectLamin Aeng
dc.subjectAgingeng
dc.subjectFrailtyeng
dc.subjectCOP cellseng
dc.subjectCirculating osteoprogenitorseng
dc.subjectFlow cytometryeng
dc.titleLamin A expression in circulating osteoprogenitors as a potential biomarker for frailty: The Nepean Osteoporosis and Frailty (NOF) Studyeng
dc.typearticlespa
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