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Nephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infection

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datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
dc.contributor.authorAroca-Martínez, Gustavo
dc.contributor.authorCadena-Bonfanti, Andrés
dc.contributor.authorAvendaño-Echavez, Lil
dc.contributor.authorConde-Manotas, Juan C.
dc.contributor.authorPérez, Rafael
dc.contributor.authorGarcía, Raúl
dc.contributor.authorOrozco, Carlos
dc.contributor.authorMusso, Carlos G.
dc.date.accessioned2023-03-29T19:56:12Z
dc.date.available2023-03-29T19:56:12Z
dc.date.issued2023
dc.description.abstractIntroduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by pulmonary involvement. However, there are reports on patients also suffering from concomitant renal involvement, with clinical manifestations such as hematuria, proteinuria, elevated nitrogen levels and acute kidney injury. Objective: The present study reports two clinical cases of nephrotic syndrome associated with coronavirus disease (COVID-19). Clinical case presentation: Histological imaging by electron microscopy showed, in one case, evidence of minimal changes and fusion of podocytes pedicels, and in the other one, podocytopathy with pedicels loss (70 %) and focal sclerosis of capillary loops. Discussion: Proteinuria in COVID-19 can be secondary to glomerular and acute tubular lesions, with a multifactorial origin: Hemodynamic factors, cytokine storms, secondary infections, druginduced nephrotoxicity and direct viral infection (proximal tubule cells and podocytes). The latter mechanisms could be explained by SARS-CoV2 renal tropism. Conclusion: The present report presents two cases of nephrotic syndrome secondary to podocytopathy in patients suffering from acute COVID-19 infection.eng
dc.description.abstractIntroducción: el síndrome respiratorio agudo severo inducido por coronavirus-2 (SARS-CoV-2) se caracteriza por la instalación de una afectación pulmonar. Sin embargo, existen reportes de afectación renal concomitante, con manifestaciones clínicas como hematuria, proteinuria y daño renal agudo. Objetivo: presentamos dos casos clínicos de síndrome nefrótico asociado a enfermedad por coronavirus (COVID-19). Presentación del caso: un paciente presentó evidencia histológica de cambios mínimos y fusión de pedicelos de podocitos en muestras histológicas evaluadas por microscopía electrónica. Discusión: la proteinuria en COVID-19 puede ser secundaria a lesiones glomerulares y tubulares agudas, con un origen multifactorial: factores hemodinámicos, tormentas de citocinas, infecciones secundarias, nefrotoxicidad inducida por fármacos e infección viral directa de las células del túbulo proximal y podocitos. Esta última podría deberse a una infección directa por el virus debido al mayor tropismo renal de este. Conclusión: el presente informe presenta dos casos de síndrome nefrótico secundario a podocitopatía en pacientes con infección aguda por COVID-19.spa
dc.format.mimetypepdfeng
dc.identifier.citationMusso CG, Aroca-Martínez G, Cadena-Bonfanti A, Avendaño-Echavez L, Conde-Manotas JC, Perez R, et al. Nephrotic Syndrome Secondary to Podocythopathy in SARS-COV2 Infection. Rev. Colomb. Nefrol. 2023; 10(2), e628. https://doi.org/10.22265/acnef.10. 2.628eng
dc.identifier.doihttps://doi.org/10.22265/acnef.10.2.628
dc.identifier.issn25005006
dc.identifier.urihttps://hdl.handle.net/20.500.12442/12108
dc.identifier.urlhttps://revistanefrologia.org/index.php/rcn/article/view/628
dc.language.isospaspa
dc.publisherAsociación Colombiana de Nefrología e Hipertensión Arterialspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionaleng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceRevista Colombiana de Nefrologíaspa
dc.sourceVol. 10 No. 2 (2023)
dc.subjectPodocytopathyeng
dc.subjectNephrotic syndromeeng
dc.subjectSARS-CoV-2spa
dc.subjectPodocitopatíaspa
dc.subjectSíndrome nefróticospa
dc.titleNephrotic Syndrome Secondary to Podocytopathy in SARS-COV2 Infectioneng
dc.title.translatedSíndrome nefrótico secundario a podocitopatía en infección por SARS-COV2spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.spaArtículo científicospa
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