Asociación entre síntomas indicativos de asma y exposición a agentes contaminantes intradomiciliarios en niños menores de 7 años. Barranquilla febrero –mayo 2019
dc.contributor.advisor | Stand Niño, Ivan | |
dc.contributor.advisor | Márquez, Moisés | |
dc.contributor.author | Castro García, Angélica | |
dc.contributor.author | Villareal Dominguez, Edimer | |
dc.date.accessioned | 2019-06-25T19:53:56Z | |
dc.date.available | 2019-06-25T19:53:56Z | |
dc.date.issued | 2019 | |
dc.description.abstract | El asma es esencialmente una enfermedad del desarrollo, en la cual el desarrollo normal de los sistemas respiratorio e inmunitario es alterado por los impactos de exposiciones ambientales actuando sobre predisposiciones genéticas subyacentes. Se presenta un estudio analítico de corte transversal con aplicación de encuesta, diseñado bajo fundamentos cuantitativos con el objetivo de determinar la asociación entre los síntomas indicativos de asma en niños menores de 7 años y la exposición a agentes contaminantes intradomiciliarios, Barranquilla, periodo febrero –mayo 2019. La muestra fue a conveniencia, constituida por todos aquellos que cumplieron los criterios de inclusión, incluyéndose un total de 326 menores (Tres Ave Marías=102 y Urbanización el Parque= 224). Se concluye que los factores contaminantes intradomiciliarios que evidenciaron mayor asociación fueron el hacinamiento, parches o franjas de hongos en las paredes de la vivienda, el no aseo diario de la vivienda, el secado de ropa en la habitación del menor y la ubicación cercana a un alto flujo vehicular y la presencia de mascotas. | spa |
dc.description.abstract | Asthma is a developmental disease, in which the normal development of the respiratory and immune systems is altered by the effects of exposures on the main genetic predispositions. We present a cross-sectional analytical study with a survey application, designed under quantitative foundations with the objective of determining the association between symptoms indicative of asthma in children under 7 years and exposure to indoor pollutants, Barranquilla, February-May 2019. The sample was at convenience, constituted by all those who met the inclusion criteria, including a total of 326 minors (Tres Ave Marias = 102 and Urbanización el Parque = 224). It is concluded that the indoor household pollutants that showed the greatest association were overcrowding, patches or strips of fungi on the walls of the dwelling, no daily cleaning of the dwelling, drying clothes in the minor's room and the location near a high traffic flow and the presence of pets. | eng |
dc.identifier.uri | https://hdl.handle.net/20.500.12442/3341 | |
dc.language.iso | spa | spa |
dc.publisher | Ediciones Universidad Simón Bolívar | spa |
dc.publisher | Facultad de Ciencias de la Salud | spa |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | eng |
dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Contaminación intradomiciliaria | spa |
dc.subject | Asma | spa |
dc.subject | Intradomiciliary contamination | eng |
dc.subject | Asthma | eng |
dc.title | Asociación entre síntomas indicativos de asma y exposición a agentes contaminantes intradomiciliarios en niños menores de 7 años. Barranquilla febrero –mayo 2019 | spa |
dc.type | Other | spa |
dcterms.references | Marfortt DA, Josviack D, Lozano A, Cuestas E, Agüero L4, Castro-Rodriguez JA. Differences between preschoolers with asthma and allergies in urban and rural environments. J Asthma. 2017;12(4):1-7. | eng |
dcterms.references | Gavidia T, Pronczuk J, Sly P. Impactos ambientales sobre la salud respiratoria de los niños. Carga global de las enfermedades respiratorias pediátricas ligada al ambiente. Rev Chil Enf Respir. 2009;25:99-108. | spa |
dcterms.references | Sun Y, Zhang Y, Sundell J, Fan Z, Bao l. Dampness in dorm rooms and its associations with allergy and airways infections among college students in China: A cross-sectional study. Indoor Air. 2009;19:348-56. | eng |
dcterms.references | Hernández A, Grineski S. Exploring the efficacy of an environmental health intervention in Ciudad Juárez, México. Fam Community Health. 2010;33:343-53. | eng |
dcterms.references | Gern JE. The Urban Environment and Childhood Asthma Study. J Allergy Clin Immunol. 2010;125:545-49. | eng |
dcterms.references | Rodríguez L, Herrera A, Castro H, Niederbacher J, Vera L. Incidencia de síntomas respiratorios y su asociación con contaminación atmosférica en preescolares: un análisis multinivel. Cad Saude Pública. 2010;26:1411-8. | spa |
dcterms.references | Herrera A, Rodríguez L, Niederbacher J. Contaminación biológica intradomiciliaria y su relación con síntomas respiratorios indicativos de asma bronquial en preescolares de Bucaramanga, Colombia. Biomédica 2011;31:357-71 | spa |
dcterms.references | Barria R, Calvo M, Pino P. Contaminación intradomiciliaria por material particulado fino (MP2,5) en hogares de recién nacidos. Rev Chil Pediatr. 2016;87(5):343-35 | spa |
dcterms.references | Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2017. Available in: www.ginasthma.org | eng |
dcterms.references | Guía de bolsillo para profesionales de la Salud Actualización de 2016. Global Initiative for Asthma. 2016. | spa |
dcterms.references | Castro-Rodriguez JA, Brockmann PE, Marcus CL. Relation between asthma and sleep disordered breathing in children: is the association causal? Paediatr Respir Rev. 2017; 22: 72-75. | eng |
dcterms.references | National Health Interview Survey, National Center for Health Statistics, Centers for Disease Control and Prevention. Hyattsville; 2015. Disponible en: http://www.cdc.gov/nchs/fastats/asthma.htm | eng |
dcterms.references | Plaza AM, Ibáñez MD, Sánchez-Solís M, Bosque-García M, Cabero MJ, Corzo JL et al. Consenso para el abordaje del asma grave pediátrica en la práctica clínica habitual. An Pediatr (Barc). 2016;84(2):67-130. DOI: 10.1016/j.anpedi.2015.08.015 | spa |
dcterms.references | Pedraza AM, Stand I, Castaño S, Ruiz JP. Asma infantil. PRECOP SCP. 2011: 10(2).36-48. | spa |
dcterms.references | Arias-López JC, Ortíz-Vidal MA, Restrepo JC. Asma en población pediátrica: Factores de riesgo y diagnóstico. Una revisión actual. Salutem Scientia Spiritus 2018; 4(1):35-40. | spa |
dcterms.references | Llanos Y, Huerta J. Actualización en el tratamiento del asma en pediatría. Alergia, Asma e Inmunologia Pediátricas. 2018;1(27):10-17 | spa |
dcterms.references | James C, Bernstein DI. Allergen immunotherapy: an updated review of safety. Curr Opin Allergy Clin Immunol. 2017; 17(1): 55-59. | eng |
dcterms.references | Hall SC, Agrawal DK. Vitamin D and bronchial asthma: an overview of data from the past 5 years hall. Clin Ther. 2017;39 (5): 917-929. | eng |
dcterms.references | Anderson H, Ruggles R, Pandey K, Kapetanakis V, et al. Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). Occup Environ Med 2010;67:293-300. | eng |
dcterms.references | Larsen ST, Matsubara S, McConville G, Poulsen S, Gelfand E. Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. J Toxicol Environ Health A 2010;73:738-747. | eng |
dcterms.references | Rodríguez L, Rey J, Herrera, AB et al. Prevalencia de síntomas respiratorios indicativos de asma y asociación con contaminación atmosférica en preescolares de Bucaramanga, Colombia. Biomédica. 2010;30:15–22. | spa |
dcterms.references | Sanchez J. Physicochemical characteristics of gaseous and particulate air pollutants. Their impact on asthma. Iatreia 2012;25:369-379. | eng |
dcterms.references | Caraballo L, Puerta L, Martinez B, Moreno L. Identification of allergens from the mite Blomia tropicalis. Clin Exp Allergy 1994;24:1056-1060. | eng |
dcterms.references | Puerta L, Fernandez-Caldas E, Mercado D, Lockey RF, Caraballo LR. Sequential determinations of Blomia tropicalis allergens in mattress and floor dust samples in a tropical city. J Allergy Clin Immunol 1996;97:689-691. | eng |
dcterms.references | Fernandez-Caldas E, Puerta L, Mercado D, Lockey RF, Caraballo LR. Mite fauna, Der p I, Der f I and Blomia tropicalis allergen levels in a tropical environment. Clin Exp Allergy 1993;23:292-297. | eng |
dcterms.references | Fernandez-Caldas E, Puerta L, Caraballo L, Mercado D, Lockey RF. Sequential determinations of Dermatophagoides spp. allergens in a tropical city. J Investig Allergol Clin Immunol 1996;6:98-102. | eng |
dcterms.references | Heinrich J, Wichmann HE. Traffic related pollutants in Europe and their effect on allergic disease. Curr Opin Allergy Clin Immunol 2004;4:341-348. | eng |
dcterms.references | Trenga CA, Sullivan JH, Schildcrout JS, Shepherd KP, et al. Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study. Chest 2006;129:1614-1622. | eng |
dcterms.references | Anderson H, Ruggles R, Pandey K, Kapetanakis V, et al. Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). Occup Environ Med 2010;67:293-300. | eng |
dcterms.references | Sánchez J, Urrego J, Zakzuk J, Bornacelly A, et al. Niveles de contaminantes en el aire de Cartagena, Colombia. Revista Salud UIS 2013;45:35-4 | spa |
dcterms.references | Sánchez J, Caraballo L. Repercusión de la contaminación del aire en la aparición de asma. Revista Alegia México 2015;62:287-301. | spa |
dcterms.references | Poynter ME, Persinger RL, Irvin CG, Butnor KJ, et al. Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse. Am J Physiol Lung Cell Mol Physiol 2006;290:144-152. | eng |
dcterms.references | Babin SM, Burkom HS, Holtry RS, Tabernero NR, et al. Pediatric patient asthma-related emergency department visits and admissions in Washington, DC, from 2001-2004, and associations with air quality, socio-economic status and age group. Environ Health 2007;6:9. | eng |
dcterms.references | Villeneuve PJ, Chen L, Rowe BH, Coates F. Outdoor air pollution and emergency department visits for asthma among children and adults: a casecrossover study in northern Alberta, Canada. Environ Health 2007;6:40. | eng |
dcterms.references | Tecer LH, Alagha O, Karaca F, Tuncel G, Eldes N. Particulate matter (PM(2.5), PM(10-2.5), and PM(10)) and children’s hospital admissions for asthma and respiratory diseases: a bidirectional case-crossover study. J Toxicol Environ Health A 2008;71:512-520. | eng |
dcterms.references | Khalequzzaman M, Kamijima M, Sakai K, Chowdhury NA, et al. Indoor air pollution and its impact on children under five years old in Bangladesh. Indoor Air 2007;17:297-304. | eng |
dcterms.references | Brauer M, Hoek G, Smit HA, de Jongste JC, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J 2007;29:879-888. | eng |
dcterms.references | Skorge TD, Eagan TM, Eide GE, Gulsvik A, Bakke PS. The adult incidence of asthma and respiratory symptoms by passive smoking in uterus or in childhood. Am J Respir Crit Care Med 2005;172:61-66. | eng |
dcterms.references | Pinkerton KE, Joad JP. Influence of air pollution on respiratory health during perinatal development. Clin Exp Pharmacol Physiol 2006;33:269-272. | eng |
dcterms.references | Sarmiento R. Prevalence of respiratory symptoms associated with outdoor and indoor air pollution in Bogota 2012;1-12 doi:10.2495/SAFE130641 | eng |
dcterms.references | Rodriguez N, Martinez V, Sarmiento R, Medina K, Hernandez L. Factores de riesgo para enfermedad respiratoria en población de 5 a 14 años de una Localidad de Bogotá, 2012-2013. Rev. salud pública. 2013;15 (3): 408-420 | spa |
dcterms.references | Marco L. Ambiente y Asma, ¿Qué hay más allá de la Alergia?. Universidad Nacional de lña Plata, 2014. 1-215 | spa |
dcterms.references | OMS. Enfermedades respiratorias crónicas.10 datos sobre asma de la Organizacion Mundial de la Salud. Disponible en: http://www.who.int/es/newsroom/ facts-in-pictures/detail/10-datos-sobre-elasma | spa |
dcterms.references | Navarrete-Rodríguez E, Sienra-Monge JJL. Asma en pediatría. Revista de la Facultad de Medicina de la UNAM 2016; 59(4):5-15. | spa |
dcterms.references | Wolsk HM, Chawes BL, Litonjua AA, Hollis BW, Waage J, Stokholm J et al. Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials. PLoS ONE. 2017;12(10):e0186657. DOI: 10.1371/journal.pone.0186657 | eng |
dcterms.references | Feleszko W, Ruszczyński M, Jaworska J, Strzelak A, Zalewski BM, Kulus M. Environmental tobacco smoke exposure and risk of allergic sensitisation in children: a systematic review and metaanalysis. Arch Dis Child. 2014; 99(11):985- 92. DOI: 10.1136/archdischild-2013-305444 | eng |
dcterms.references | Johnston CF, Broom M, Shadbolt B, Todd DA. Smoking in the family is most predictive of the development of childhood asthma in preterm babies <30 weeks gestation: Results of the Respiratory Outcomes Study 2 (REPOS2). J Asthma. 2018; 55(7):705-711. DOI: 10.1080/02770903.2017.1366508 | eng |
dcterms.references | Voge GA, Carey WA, Ryu E, King KS, Wi CI, Juhn YJ. What accounts for the association between late preterm births and risk of asthma? Allergy Asthma Proc. 2017; 38(2):152-6. DOI: 10.2500/ aap.2017.38.4021 | eng |
dcterms.references | Haataja P, Korhonen P, Ojala R, Hirvonen M, Paassilta M, Gissler M, Luukkaala T, Tammela O. Asthma and atopic dermatitis in children born moderately and late preterm. Eur J Pediatr. 2016;175(6):799-808. DOI: 10.1007/s00431-016-2708-8 | eng |
dcterms.references | Oland AA. Psychological and lifestyle risk factors for asthma exacerbations and morbidity in children. World Allergy Organ J. 2017; 10(1):35. DOI: 10.1186/s40413-017-0169-9 | eng |
dcterms.references | Kashanian M, Mohtashami SS, Bemanian MH, Moosavi SAJ, Moradi Lakeh M. Evaluation of the associations between childhood asthma and prenatal and perinatal factors. Int J Gynaecol Obstet. 2017; 137(3):290-4. DOI: 10.1002/ijgo.12141 | eng |
dcterms.references | Hallit S, Raherison C, Abou Abdallah R, Hallit R, Salameh P. Correlation of types of food and asthma diagnosis in childhood: A case-control study. J Asthma. 2017; 19:1-9. DOI:10.1080/027709 03.2017.1379535 | eng |
dcterms.references | Hattevig G, Kjellman B, Björkstén B. Appearance of IgE antibodies to ingested and inhaled allergens during the first 12 years of life in atopic and non-atopic children. Pediatr Allergy Immunol. 1993;4(4):182-6. | eng |
dcterms.references | Ozturk AB, Turturice BA, Perkins DL, Finn PW. The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma. Curr Allergy Asthma Rep. 2017; 17(9):62. DOI: 10.1007/s11882-017-0730-1 | eng |
dcterms.references | Reynolds LA, Finlay BB. Early life factors that affect allergy development. Nat Rev Immunol. 2017; 17(8):518-28. DOI:10.1038/nri.2017.39 | eng |
dcterms.references | Lambert KA, Prendergast LA. The role of human rinovirus (HRV) species on asthma exacerbation severity in children and adolescents. J Asthma. 2018; 55(6):596-602. DOI:10.1080/02770903.2017.1362425 | eng |
dcterms.references | Jartti T, Gern JE. Role of viral infections in the development and exacerbation of asthma in children. J Allergy Clin Immunol. 2017; 140(4):895-906. DOI: 10.1016/j.jaci.2017.08.003 | eng |
dcterms.references | Herrera Am. Vitamina D y Asma: Artículo de revisión. Rev Chil Enf Respir. 2013; 29:149-54. | spa |
dcterms.references | Dunn NA, Neff LA, Maurer DM. A stepwise approach to pediatric asthma. J FamPract. 2017;66(5):280-6. | eng |
dcterms.references | National Heart Lung and Blood Institute. Asthma care quick reference: Diagnosing and managing asthma. 2012. | eng |
dcterms.references | Sánchez-García S, Habernau Mena A, Quirce S. Biomarkers in inflammometry pediatric asthma: Utility in daily clinical practice. Eur Clin Respir J. 2017; 4(1):1356- 60. | eng |
dcterms.references | Keller AC, Rodriguez D, Russo M. Nitric oxide paradox in asthma. Mem Inst Oswaldo Cruz 2005;100:19-23. | eng |
dcterms.references | Anderson SE, Wells JR, Fedorowicz A, Butterworth LF, et al. Evaluation of the contact and respiratory sensitization potential of volatile organic compounds generated by simulated indoor air chemistry. Toxicol Sci 2007;97:355-363. | eng |
dcterms.references | Nygaard UC, Ormstad H, Aase A, Løvik M. The IgE adjuvant effect of particles: characterisation of the primary cellular response in the draining lymph node. Toxicology 2005;206:181-193. | eng |
dcterms.references | Samuelsen M, Nygaard UC, Lovik M. Allergy adjuvant effect of particles from wood smoke and road traffic. Toxicology 2008;246:124-131. | eng |
dcterms.references | Pandya RJ, Solomon G, Kinner A, Balmes JR. Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect 2002;110:103-112. | eng |
dcterms.references | Leikauf GD. Hazardous air pollutants and asthma. Environ Health Perspect 2002;110:505-526. | eng |
dcterms.references | Hayes J, Strange RC. Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radic Res 1995;22:193- 207. | eng |
dcterms.references | Lim HB, Ichinose T, Miyabara Y, Takano H, et al. Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice. Free Radic Biol Med 1998;25:635-644. | eng |
dcterms.references | Li N, Xia T, Nel AE. The role of oxidative stress in ambient particulate matterinduced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 2008;44:1689-1699. | eng |
dcterms.references | Fakhrzadeh L, Laskin JD, Laskin DL. Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50. Am J Physiol Lung Cell Mol Physiol 2004;287:279-285. | eng |
dcterms.references | Cho HY, Zhang LY, Kleeberger SR. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Am J Physiol Lung Cell Mol Physiol 2001;280:537-546. | eng |
dcterms.references | Cho HY, Morgan DL, Bauer AK, Kleeberger SR. Signal transduction pathways of tumor necrosis factor–mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med 2007;175:829-839. | eng |
dcterms.references | Kleeberger SR, Reddy SP, Zhang LY, Cho HY, Jedlicka AE. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 2001;280:326-333. | eng |
dcterms.references | Dong L, Li H, Wang S, Li Y. Different doses of lipopolysaccharides regulate the lung inflammation of asthmatic mice via TLR4 pathway in alveolar macrophages. J Asthma 2009;46:229-233. | eng |
dcterms.references | Arif A, Shah SM. Association between personal exposure to volatile organic compounds and asthma among US adult population. Int Arch Occup Environ Health 2007;80:711-719. | eng |
dcterms.references | Abe S, Takizawa H, Sugawara I, Kudoh S. Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitro. Am J Respir Cell Mol Biol 2000;22:296-303. | eng |
dcterms.references | Eisenbarth S, Piggott D, Huleatt J, Visintin I, et al. Lipopolysaccharideenhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002;196:1645-1651. | eng |
dcterms.references | Hollingsworth J, Free M, Li Z, Andrews L, et al. Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4- dependent mechanism. J Allergy Clin Immunol 2010;125:1167-1170. | eng |
dcterms.references | Garantziotis S, Li Z, Potts E, Lindsey J, et al. TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. Am J Respir Crit Care Med 2010;181:666-675. | eng |
dcterms.references | Larsen ST, Matsubara S, McConville G, Poulsen S, Gelfand E. Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. J Toxicol Environ Health A 2010;73:738-747. | eng |
dcterms.references | Diaz-Sanchez D, Garcia MP, Wang M, Jyrala M, Saxon A. Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa. J Allergy Clin Immunol 1999;104:1183-1188. | eng |
dcterms.references | Diaz-Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol 1997;158:2406-2413. | eng |
dcterms.references | Diaz-Sanchez D, Dotson AR, Takenaka H, Saxon A. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest 1994;94:1417-1425. | eng |
dcterms.references | Nygaard UC, Aase A, Lovik M. The allergy adjuvant effect of particles-genetic factors influence antibody and cytokine responses. BMC Immunol 2005;6:11. | eng |
dcterms.references | Akbari O, DeKruyff R, Umetsu D. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001;2:725-731. | eng |
dcterms.references | Fahy O, Senechal S, Pène J, Scherpereel A, et al. Diesel exposure favors Th2 cell recruitment by mononuclear cells and alveolar macrophages from allergic patients by differentially regulating macrophage-derived chemokine and IFNgamma- induced protein-10 production. J Immunol 2002;168:5912-5919. | eng |
dcterms.references | Alexis NE, Zhou H, Lay JC, Harris B, et al. The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects. J Allergy Clin Immunol 2009;124:1222-1228. | eng |
dcterms.references | Lommatzsch M, Bratke K, Knappe T, Bier A, et al. Acute effects of tobacco smoke on human airway dendritic cells in vivo. Eur Respir J 2010;35:1130-1136. | eng |
dcterms.references | Sénéchal S, de Nadai P, Ralainirina N, Scherpereel A, et al. Effect of diesel on chemokines and chemokine receptors involved in helper T cell type 1/type 2 recruitment in patients with asthma. Am J Respir Crit Care Med 2003;168:215-221. | eng |
dcterms.references | Le Bellego F, Plante S, Chakir J, Hamid Q, Ludwig MS. Differences in MAP kinase phosphorylation in response to mechanical strain in asthmatic fibroblasts. Respir Res 2006;7:68. | eng |
dcterms.references | Quintana FJ, Basso AS, Iglesias AH, Korn T, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008;453:65- 71. | eng |
dcterms.references | Veldhoen M, Hirota K, Westendorf AM, Buer J, et al. The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins. Nature 2008;453:106-109. | eng |
dcterms.references | Stevens EA, Bradfield CA. Immunology: T cells hang in the balance. Nature 2008;453:46-47. | eng |
dcterms.references | Wilson RH, Whitehead GS, Nakano H, Free ME, et al. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 2009;180:720-730. | eng |
dcterms.references | Krishnamoorthy N, Oriss TB, Paglia M, Fei M, et al. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med 2008;14:565-573. | eng |
dcterms.references | VC. Epigenetics in asthma. Iatreia 2009;22:359-271. | eng |
dcterms.references | Marwick JA, Kirkham PA, Stevenson CS, Danahay H, et al. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J Respir Cell Mol Biol 2004;31:633-642. | eng |
dcterms.references | Ito K, Caramori G, Lim S, Oates T, et al. Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 2002;166:392-396. | eng |
dcterms.references | Adcock IM, Ford P, Ito K, Barnes PJ. Epigenetics and airways disease. Respir Res 2006;7:21. | eng |
dcterms.references | Liu F, Killian JK, Yang M, Walker RL, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 2010;29:3650-3664. | eng |
dcterms.references | Yang IV, Schwartz DA. Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol 2012;130:1243-1255. | eng |
dcterms.references | Liu J, Ballaney M, Al-alem U, Quan C, et al. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci 2008;102:76-81. | eng |
dcterms.references | Breton C, Byun H, Wenten M, Pan F, et al. Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 2009;180:462-467. | eng |
dcterms.references | Jiang R, Jones MJ, Sava F, Kobor MS, Carlsten C. Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics. Part Fibre Toxicol 2014;11:71. | eng |
dcterms.references | Borgie M, Ledoux F, Verdin A, Cazier F, et al. Genotoxic and epigenotoxic effects of fine particulate matter from rural and urban sites in Lebanon on human bronchial epithelial cells. Environ Res 2015;136:352-362. | eng |
dcterms.references | Kohli A, Garcia MA, Miller RL, Maher C, et al. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. Clin Epigenetics 2012;4:17. | eng |
dcterms.references | Hew KM, Walker AI, Kohli A, Garcia M, et al. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clin Exp Allergy 2015;45:238-248. | eng |
dcterms.references | Vrijens K, Bollati V, Nawrot TS. MicroRNAs as potential signatures of environmental exposure or effect: a systematic review. Environ Health Perspect 2015;123:399-411. | eng |
dcterms.references | Zhou F, Li S, Jia W, Lv G, et al. Effects of diesel exhaust particles on microRNA-21 in human bronchial epithelial cells and potential carcinogenic mechanisms. Mol Med Rep 2015;12:2329-2335. | eng |
dcterms.references | Knox RB, Suphioglu C, Taylor P, Desai R, et al. Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution. Clin Exp Allergy 1997;27:246-251. | eng |
dcterms.references | Ormstad H. Suspended particulate matter in indoor air: adjuvants and allergen carriers. Toxicology 2000;152:53-68. | eng |
dcterms.references | Yeh KW, Chang CJ, Huang JL. The association of seasonal variations of asthma hospitalization with air pollution among children in Taiwan. Asian Pac J Allergy Immunol 2011;29:34-41. | eng |
dcterms.references | Behrendt H, Becker WM, Fritzsche C, Sliwa-Tomczok W, et al. Air pollution and allergy: experimental studies on modulation of allergen release from pollen by air pollutants. Int Arch Allergy Immunol 1997;113:69-74. | eng |
dcterms.references | Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, et al. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101. PLoS One 2014;9:104520. | eng |
dcterms.references | Kleeberger SR. Genetic aspects of pulmonary responses to inhaled pollutants. Exp Toxicol Pathol 2005;57:147-153. | eng |
dcterms.references | Kleeberger SR. Genetic aspects of susceptibility to air pollution. Eur Respir J Suppl 2003;40:52-56. | eng |
dcterms.references | Kleeberger SR, Levitt RC, Zhang LY, Longphre M, et al. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nat Genet 1997;17:475-478. | eng |
dcterms.references | Cho HY, Zhang LY, Kleeberger SR. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-a receptors. Am J Physiol Lung Cel Mol Physiol 2001;280:537. | eng |
dcterms.references | Bernstein JA, Alexis N, Barnes C, Bernstein IL, et al. Health effects of air pollution. J Allergy Clin Immunol 2004;114:1116-1123. | eng |
dcterms.references | Winterton DL, Kaufman J, Keener CV, Quigley S, et al. Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma. Ann Allergy Asthma Immunol 2001;86:232-238. | eng |
dcterms.references | Ohtsuka Y, Brunson KJ, Jedlicka AE, Mitzner W, et al. Genetic linkage analysis of susceptibility to particle exposure in mice. Am J Respir Cell Mol Biol 2000;22:574-581. | eng |
dcterms.references | Ohtsuka Y, Clarke RW, Mitzner W, Brunson K, et al. Interstrain variation in murine susceptibility to inhaled acid-coated particles. Am J Physiol Lung Cell Mol Physiol 2000;278:469-476. | eng |
dcterms.references | Kleeberger SR, Reddy S, Zhang LY, Jedlicka AE. Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am J Respir Cell Mol Biol 2000;22:620-627. | eng |
dcterms.references | Cho HY, Jedlicka AE, Clarke R, Kleeberger SR. Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash. Physiol Genomics 2005;22:108-117. | eng |
dcterms.references | Wesselkamper SC, Chen LC, Gordon T. Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice. Respir Res 2005;6:73. | eng |
dcterms.references | von Mutius E, Le Souëf PN. Early gene-environment interactions: can they inform primary preventive strategies for asthma? Semin Respir Crit Care Med 2007;28:255-263. | eng |
dcterms.references | Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Effect of glutathione-Stransferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363:119- 125. | eng |
dcterms.references | Lee YL, Lin YC, Lee YC, Wang JY, et al. Glutathione S-transferase P1 gene polymorphism and air pollution as interactive risk factors for childhood asthma. Clin Exp Allergy 2004;34:1707-1713. | eng |
dcterms.references | Kabesch M, Hoefler C, Carr D, Leupold W, et al. Glutathione S transferase deficiency and passive smoking increase childhood asthma. Thorax 2004;59:569- 573. | eng |
dcterms.references | Gilliland FD, Li YF, Gong H Jr., Diaz-Sanchez D. Glutathione s-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke. Am J Respir Crit Care Med 2006;174:1335-1341. | eng |
dcterms.references | Romieu I, Ramirez-Aguilar M, Sienra-Monge JJ, Moreno-Macias H, et al. GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J 2006;28:953-959. | eng |
dcterms.references | Islam T, Berhane K, McConnell R, Gauderman W, et al. Glutathione-Stransferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax 2009;64:197-202. | eng |
dcterms.references | London SJ. Gene-air pollution interactions in asthma. Proc Am Thorac Soc 2007;4:217-220. | eng |
dcterms.references | Romieu I, Meneses F, Ramirez M, Ruiz S, et al. Antioxidant supplementation and respiratory functions among workers exposed to high levels of ozone. Am J Respir Crit Care Med 1998;158:226-232. | eng |
dcterms.references | Gavidia T, Pronczuk J, Sly PD. Impactos ambientales sobre la salud respiratoria de los niños: carga global de las enfermedades respiratorias pediátricas ligada al ambiente. Rev chil enferm respir. 2009;25(2):99–108 | spa |
sb.programa | Especialización en Pediatría | spa |
sb.sede | Sede Barranquilla | spa |
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