Viabilidad del adipocito asociado al uso de ácido tranexámico: efecto en la neovascularización, adaptabilidad y citomorfología adipocítica
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Fecha
2025
Autores
Contreras Ríos, Arturo
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
Introducción: El ácido tranexámico (ATX) es un fármaco antifibrinolítico sintético,
accesible y económico, aprobado para la administración intravenosa, tópica y oral,
utilizado principalmente para reducir el sangrado y favorecer la hemostasia. Sin
embargo, los efectos de impregnación del (AXT) en el tejido adiposo no se han
estudiado.
Objetivo: Evaluar el efecto de diferentes dosis de impregnación con ATX in vitro, en
muestras de tejido adiposo a través del estudio histológico por medio de
microscopía óptica sobre la viabilidad, neovascularización, adaptación y
citomorfología adipocítica.
Metodología: Las muestras de tejido adiposo fueron obtenidas por escisión en
bloque de abdominoplastia fijadas con formol y teñidas con la técnica de
Hematoxilina-Eosina (H-E). Se realizó análisis histológico para comparar la muestra
control con las muestras tratadas con ATX a 50, 100 y 500 mg.
Conclusiones: A las concentraciones más altas de 100-500mg se observó la
morfología del adipocito preservado con aumento de capilares y cantidad menor de
tejido fibroconectivo. La preservación de la citoestructura, integración y la
funcionalidad del adipocito resulta esencial para lograr resultados regenerativos,
reconstructivos y estéticos óptimos y seguros.
Introduction: Tranexamic acid (TXA) is an approved, cost-effective synthetic antifibrinolytic agent. It has been widely used both intravenously and orally as a systemic prophylactic treatment, reducing bleeding and the need for blood transfusions by 30% to 40%. However, its application in fat grafting procedures has not been studied, highlighting the need to evaluate its viability in this context. Objectives: To assess, through histological analysis, the effects and viability of adipose tissue in association with the use of TXA in vitro. Methodology: Dermo-adipose tissue samples were obtained via block excision during abdominoplasty. Histological analysis will involve the comparison of control samples and samples treated with tranexamic acid at 50, 100 & 500 mg previously fixed with formol Conclusions: At the highest concentration, preservation of adipose tissue was observed, with cytomorphological integrity of adipocytes and evidence of focal vascular proliferation. These findings suggest that ATX is a safe and effective option not only for minimizing bleeding, but also for promoting adipocyte viability and integration.
Introduction: Tranexamic acid (TXA) is an approved, cost-effective synthetic antifibrinolytic agent. It has been widely used both intravenously and orally as a systemic prophylactic treatment, reducing bleeding and the need for blood transfusions by 30% to 40%. However, its application in fat grafting procedures has not been studied, highlighting the need to evaluate its viability in this context. Objectives: To assess, through histological analysis, the effects and viability of adipose tissue in association with the use of TXA in vitro. Methodology: Dermo-adipose tissue samples were obtained via block excision during abdominoplasty. Histological analysis will involve the comparison of control samples and samples treated with tranexamic acid at 50, 100 & 500 mg previously fixed with formol Conclusions: At the highest concentration, preservation of adipose tissue was observed, with cytomorphological integrity of adipocytes and evidence of focal vascular proliferation. These findings suggest that ATX is a safe and effective option not only for minimizing bleeding, but also for promoting adipocyte viability and integration.
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Palabras clave
Ácido tranexámico, Adipocito, Injerto de adipocitos, Viabilidad
