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Intrinsic and environmental basis of aging: A narrative review

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorNavarro, Carla
dc.contributor.authorSalazar, Juan
dc.contributor.authorDíaz, María P.
dc.contributor.authorChacin, Maricarmen
dc.contributor.authorSanteliz, Raquel
dc.contributor.authorVera, Ivana
dc.contributor.authorD'Marco, Luis
dc.contributor.authorParra, Heliana
dc.contributor.authorBernal, Mary Carlota
dc.contributor.authorCastro, Ana
dc.contributor.authorEscalona, Daniel
dc.contributor.authorGarcía-Pacheco, Henry
dc.contributor.authorBermúdez, Valmore
dc.date.accessioned2023-09-07T19:54:17Z
dc.date.available2023-09-07T19:54:17Z
dc.date.issued2023
dc.description.abstractLongevity has been a topic of interest since the beginnings of humanity, yet its aetiology and precise mechanisms remain to be elucidated. Aging is currently viewed as a physiological phenomenon characterized by the gradual degeneration of organic physiology and morphology due to the passage of time where both external and internal stimuli intervene. The influence of intrinsic factors, such as progressive telomere shortening, genome instability due to mutation buildup, the direct or indirect actions of age-related genes, and marked changes in epigenetic, metabolic, and mitochondrial patterns constitute a big part of its underlying endogenous mechanisms. On the other hand, several psychosocial and demographic factors, such as diet, physical activity, smoking, and drinking habits, may have an even more significant impact on shaping the aging process. Consequentially, implementing dietary and exercise patterns has been proposed as the most viable alternative strategy for attenuating the most typical degenerative aging changes, thus increasing the likelihood of prolonging lifespan and achieving successful aging.eng
dc.format.mimetypepdfeng
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2023.e18239
dc.identifier.issn24058440
dc.identifier.urihttps://hdl.handle.net/20.500.12442/13249
dc.language.isoengeng
dc.publisherElsevier Ltd.eng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceHeliyoneng
dc.sourceVolume 9, Issue 8 (2023)
dc.subjectAgingeng
dc.subjectTelomereseng
dc.subjectTelomeraseeng
dc.subjectObesityeng
dc.subjectChronic diseaseseng
dc.subjectAge-related geneseng
dc.titleIntrinsic and environmental basis of aging: A narrative revieweng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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