Susceptibilidad genética frente al cáncer bucal por la infección del virus del papiloma humano
| dc.contributor.advisor | Yáñez Torregrosa, Zuleima | spa |
| dc.contributor.author | Rebolledo Cobos, Martha | spa |
| dc.date.accessioned | 2019-02-01T21:02:07Z | |
| dc.date.available | 2019-02-01T21:02:07Z | |
| dc.date.issued | 2019-01 | |
| dc.description.abstract | Los carcinógenos ambientales y el virus del papiloma humano (VPH), son los primordiales responsables del cáncer bucal (CB), factores de susceptibilidad en el genoma humano juegan un papel modulador del riesgo, sin embargo no todos los individuos expuestos a estos carcinógenos padecen cáncer. El objetivo de la presente revisión es describir los principales factores de susceptibilidad genética frente a CB por la infección del VPH, realizando una búsqueda sistemática en tres bases de datos en inglés; donde finalmente solo 7 artículos cumplieron con los criterios de selección. Se muestran polimorfismos genéticos en tres categorías importantes relacionados con el VPH y participando en la oncogénesis, evidenciándose tres artículos relativos a la desregulación de los mecanismos de control del ciclo celular, un artículo referente a mutaciones en la vía de la apoptosis y tres artículos con respecto a polimorfismos en genes de respuesta inflamatoria e inmune. El estudio de la asociación de polimorfismos para el desarrollo de CB frente al VPH es evidente, aunque se mantiene en estudio, no siempre el patrón de oncogénesis de todos los CB se encuentran relacionados solo con la presencia del VPH, si no, a otros factores ambientales o epigenéticos. | spa |
| dc.description.abstract | Environmental carcinogens and the human papillomavirus (HPV), are the primary responsible for oral cancer (CB), susceptibility factors in the human genome play a risk modulator role, however not all individuals exposed to these carcinogens suffer from cancer . The aim of the present review is to describe the main factors of genetic susceptibility to CB for HPV infection, carrying out a systematic search in three databases in English; where finally only 7 articles met the selection criteria. Genetic polymorphisms are shown in three important categories related to HPV and participating in oncogenesis, evidencing three articles related to the deregulation of cell cycle control mechanisms, an article referring to mutations in the pathway of apoptosis and three articles with respect to to polymorphisms in inflammatory and immune response genes. The study of the association of polymorphisms for the development of CB against HPV is evident, although it remains under study, not always the pattern of oncogenesis of all CB are related only to the presence of HPV, if not, to other factors environmental or epigenetic. | eng |
| dc.identifier.uri | http://hdl.handle.net/20.500.12442/2549 | |
| dc.language.iso | spa | spa |
| dc.publisher | Ediciones Universidad Simón Bolívar | spa |
| dc.publisher | Facultad de Ciencias Básicas y Biomédicas | spa |
| dc.publisher | Programa de Maestría en Genética | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.license | Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional | spa |
| dc.subject | Susceptibilidad genética | spa |
| dc.subject | Cáncer bucal | spa |
| dc.subject | Polimorfismos | spa |
| dc.subject | Infección por VPH | spa |
| dc.subject | Mutación | spa |
| dc.subject | (DECS) | spa |
| dc.subject | Genetic susceptibility | eng |
| dc.subject | Oral cancer | eng |
| dc.subject | Polymorphisms | eng |
| dc.subject | HPV infection | eng |
| dc.subject | Mutation | eng |
| dc.subject | (MESH) | eng |
| dc.title | Susceptibilidad genética frente al cáncer bucal por la infección del virus del papiloma humano | spa |
| dc.type | article | spa |
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