Tuberculosis en pacientes pediátricos en el departamento del Atlántico, Colombia (2021– 2023)
| datacite.rights | http://purl.org/coar/access_right/c_16ec | |
| dc.contributor.advisor | Rodriguez Gomez , Luis Daniel | |
| dc.contributor.advisor | González Torres, Henry Joseth | |
| dc.contributor.author | Tatis Geney, Steffany Isabel | |
| dc.date.accessioned | 2026-02-04T21:21:32Z | |
| dc.date.available | 2026-02-04T21:21:32Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Introducción: La tuberculosis (TB) pediátrica continúa siendo un problema de salud pública relevante, especialmente en países en desarrollo, donde la desnutrición y las condiciones de vulnerabilidad social incrementan el riesgo de desenlaces desfavorables. Objetivo: Evaluar las características sociodemográficas, clínicas y paraclínicas y su impacto en los desenlaces del tratamiento en pacientes pediátricos diagnosticados con tuberculosis en el departamento del Atlántico entre 2021 y 2023. Métodos: Se realizó un estudio analítico, retrospectivo y transversal basado en el registro departamental de tuberculosis del Atlántico (Colombia), entre 2021 y 2023. Se incluyeron pacientes pediátricos de 1 a 18 años con diagnóstico confirmado de TB. Se evaluaron variables sociodemográficas, clínicas, paraclínicas y terapéuticas. Se aplicaron pruebas estadísticas comparativas, curvas de Kaplan-Meier y modelos de regresión de Cox. Resultados: Se analizaron 83 pacientes, de los cuales 21,7 % fallecieron. El 59 % eran masculinos y la mediana de edad fue 15 años; los fallecidos fueron significativamente más jóvenes (10 años; p=0,045). La desnutrición fue más frecuente en fallecidos (33 % vs 14 %) y se asoció con mayor riesgo de mortalidad (HR=3,73; IC95 %: 1,19–11,7; p=0,024). La neoplasia se presentó únicamente en fallecidos (11 %; p=0,045). La sobrevida a 12 meses no difirió entre TB pulmonar y extrapulmonar (75,5 % vs 60 %; p=0,56). Los pacientes con prueba molecular positiva tuvieron mayor probabilidad de sobrevida (73,7 % vs 48,3 %; p=0,03). Conclusiones: La desnutrición es un predictor independiente de mortalidad en TB pediátrica, mientras que la detección molecular temprana se asocia con mayor sobrevida. Estos hallazgos resaltan la necesidad de integrar programas de soporte nutricional y ampliar la cobertura de pruebas moleculares en el manejo de la TB infantil en contextos de alta vulnerabilidad. | spa |
| dc.description.abstract | Background: Pediatric tuberculosis (TB) remains a major public health challenge, particularly in low- and middle-income countries where malnutrition and social vulnerability increase the risk of poor outcomes. Objective: To evaluate the sociodemographic, clinical, and paraclinical characteristics and their impact on treatment outcomes in pediatric patients diagnosed with tuberculosis in the department of Atlántico, Colombia, between 2021 and 2023. Methods: We conducted an analytical, retrospective, cross-sectional study using the official TB registry from Atlántico, Colombia, between 2021 and 2023. Children and adolescents aged 1–18 years with confirmed TB were included. Sociodemographic, clinical, paraclinical, and therapeutic variables were assessed. Comparative statistical tests, Kaplan-Meier survival curves, and Cox regression models were applied. Results: A total of 83 patients were analyzed; 21.7 % died during follow-up. Overall, 59 % were male, with a median age of 15 years; deceased patients were significantly younger (10 years; p=0.045). Malnutrition was more frequent among deceased patients (33 % vs 14 %) and independently associated with mortality (HR=3.73; 95 %CI: 1.19–11.7; p=0.024). Neoplasia was exclusively observed in deceased patients (11 %; p=0.045). Twelve-month survival did not differ between pulmonary and extrapulmonary TB (75.5 % vs 60 %; p=0.56). Patients with positive molecular tests had higher survival probability (73.7 % vs 48.3 %; p=0.03). Conclusions: Malnutrition is an independent predictor of mortality in pediatric TB, while early molecular detection is associated with increased survival. These findings highlight the importance of strengthening nutritional support programs and expanding access to molecular diagnostics for pediatric TB in vulnerable settings. | eng |
| dc.format.mimetype | ||
| dc.identifier.uri | https://hdl.handle.net/20.500.12442/17334 | |
| dc.language.iso | spa | |
| dc.publisher | Ediciones Universidad Simón Bolívar | spa |
| dc.publisher | Facultad de Ciencias de la Salud | spa |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | |
| dc.subject | Tuberculosis Pediátrica | spa |
| dc.subject | Desnutrición | spa |
| dc.subject | Análisis de Supervivencia | spa |
| dc.subject | Técnicas de Diagnóstico Molecular | spa |
| dc.subject | Factores de Riesgo | spa |
| dc.subject.keywords | Tuberculosis, Pediatric | eng |
| dc.subject.keywords | Malnutrition | eng |
| dc.subject.keywords | Survival Analysis | eng |
| dc.subject.keywords | Molecular Diagnostic Techniques | eng |
| dc.subject.keywords | Risk Factors | eng |
| dc.title | Tuberculosis en pacientes pediátricos en el departamento del Atlántico, Colombia (2021– 2023) | spa |
| dc.type.driver | info:eu-repo/semantics/other | |
| dc.type.spa | Otros | |
| dcterms.references | Organization WH. Sep 30. 2025. p. 4 Tuberculosis fact sheet. Available from: https://www.who.int/news-room/fact-sheets/detail/tuberculosis | eng |
| dcterms.references | Marais BJ. Tuberculosis in children. | eng |
| dcterms.references | Roya-Pabón C, Restrepo A, Morales O, Arango C, Maya MA, Bermúdez M, et al. Acute Intrathoracic Tuberculosis in Children and Adolescents with Community-Acquired Pneumonia in an Area with an Intermediate Disease Burden. Pediatr Rep [Internet]. 2022 Feb 5;14(1):71–80. Available from: https://www.mdpi.com/2036-7503/14/1/11 | eng |
| dcterms.references | Moore BK, Graham SM, Nandakumar S, Doyle J, Maloney SA. Pediatric Tuberculosis: A Review of Evidence-Based Best Practices for Clinicians and Health Care Providers. Pathog (Basel, Switzerland) [Internet]. 2024 Jun 1;13(6). Available from: http://www.ncbi.nlm.nih.gov/pubmed/38921765 | eng |
| dcterms.references | World Health Organization W. Global Tuberculosis Report 2023. Vol. t/malaria/, January. 2023. 75 p. | eng |
| dcterms.references | Dodd PJ, Yuen CM, Sismanidis C, Seddon JA, Jenkins HE. The global burden of tuberculosis mortality in children: a mathematical modelling study. Lancet Glob Heal [Internet]. 2017 Sep;5(9):e898–906. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28807188 | eng |
| dcterms.references | Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA, et al. Adolescent tuberculosis. Lancet Child Adolesc Heal. 2020 Jan;4(1):68–79. | eng |
| dcterms.references | Plata-Casas L, González-Támara L, Cala-Vitery F. Tuberculosis Mortality in Children under Fifteen Years of Age: Epidemiological Situation in Colombia, 2010-2018. Trop Med Infect Dis [Internet]. 2022 Jun 25;7(7). Available from: http://www.ncbi.nlm.nih.gov/pubmed/35878129 | eng |
| dcterms.references | Yunda LFI, Sepúlveda EVF, Herrera KCM, Moreno GC. Pulmonary tuberculosis in a Pediatric Reference Hospital in Bogotá, Colombia. Int J mycobacteriology [Internet]. 2017;6(3):258–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28776524 | eng |
| dcterms.references | Ministerio de Salud y Protección Social de Colombia. Informe de Tuberculosis 2022 [Internet]. 2022. Available from: https://www.minsalud.gov.co | eng |
| dcterms.references | Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B. Paediatric tuberculosis. Lancet Infect Dis. 2008 Aug;8(8):498–510. | eng |
| dcterms.references | Tristram D, Tobin EH. Tuberculosis in Children [Internet]. StatPearls. 2025. Available from: http://www.ncbi.nlm.nih.gov/pubmed/37919487 | eng |
| dcterms.references | Nicol MP, Gnanashanmugam D, Browning R, Click ES, Cuevas LE, Detjen A, et al. A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis. Clin Infect Dis. 2015 Oct;61Suppl 3(Suppl 3):S164- 72. | eng |
| dcterms.references | Jenkins HE, Yuen CM. The burden of multidrug-resistant tuberculosis in children. Int J Tuberc Lung Dis. 2018 May;22(5):3–6. | eng |
| dcterms.references | Gaensbauer JT, Dash N, Verma S, Hall DJ, Adler-Shohet FC, Li G, et al. Multidrug-resistant tuberculosis in children: A practical update on epidemiology, diagnosis, treatment and prevention. J Clin Tuberc other Mycobact Dis. 2024 Aug;36:100449. | eng |
| dcterms.references | Torres-Duque CA, Fuentes Alcalá ZM, Rendón A, Migliori GB. Roadmap for Tuberculosis Elimination in Latin America and the Caribbean. Arch Bronconeumol. 2018 Jan;54(1):7–9. | eng |
| dcterms.references | Ministerio de Salud y Protección Social de Colombia. Guía de práctica clínica para la prevención, diagnóstico y tratamiento de la tuberculosis. 2022. | spa |
| dcterms.references | Ukoaka BM, Daniel FM, Wagwula PM, Ahmed MM, Udam NG, Okesanya OJ, et al. Prevalence, clinical characteristics, and treatment outcomes of childhood tuberculosis in Nigeria: a systematic review and meta-analysis. BMC Infect Dis. 2024 Dec;24(1):1447. | eng |
| dcterms.references | Seddon JA, Chiang SS, Esmail H, Coussens AK. The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis? Front Immunol. 2018;9:2946. | eng |
| dcterms.references | Miggiano R, Rizzi M, Ferraris DM. Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment. Pathog (Basel, Switzerland). 2020 May;9(5). | eng |
| dcterms.references | Kramnik I, Beamer G. Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies. Semin Immunopathol. 2016 Mar;38(2):221–37. | eng |
| dcterms.references | Rosser A, Stover C, Pareek M, Mukamolova G V. Resuscitation-promoting factors are important determinants of the pathophysiology in Mycobacterium tuberculosis infection. Crit Rev Microbiol. 2017 Sep;43(5):621–30. | eng |
| dcterms.references | World Health Organization. Global Tuberculosis Report 2024. World Health Organization W, editor. Geneva: WHO; 2024. 2024. 68 p. | eng |
| dcterms.references | Goletti D, Meintjes G, Andrade BB, Zumla A, Shan Lee S. Insights from the 2024 WHO Global Tuberculosis Report - More Comprehensive Action, Innovation, and Investments required for achieving WHO End TB goals. Int J Infect Dis. 2025 Jan;150:107325. | eng |
| dcterms.references | Garcia-Bereguiain MA, Rodriguez-Pazmiño AS, Franco-Sotomayor G, Orlando SA, González M, Ugarte-Gil C. “The end TB strategy” pathway in South America: out of track for 2025 milestones and 2035 eradication. Lancet Reg Heal - Am. 2025 Apr;44:101045. | eng |
| dcterms.references | Verkuijl S, Bastard M, Brands A, Viney K, Masini T, Mavhunga F, et al. Global reporting on TB in children and adolescents: how far have we come and what remains to be done? IJTLD open. 2024 Jan;1(1):3–6. | eng |
| dcterms.references | López DS, Valderrama Vergara JF, Fernández-Niño JA, Trujillo-Cáceres SJ. Tuberculosis and immigration: the challenges in the Latin American and Colombian context. Lancet Reg Heal Am. 2023 Nov;27:100600. | eng |
| dcterms.references | Williams PM, Pratt RH, Walker WL, Price SF, Stewart RJ, Feng PJI. Tuberculosis - United States, 2023. MMWR Morb Mortal Wkly Rep. 2024 Mar;73(12):265–70. | eng |
| dcterms.references | Cruz Martínez OA, García I, Puerto GM, Alvis-Zakzuk NJ, López MP, Moreno Cubides JC, et al. Tuberculosis patients face high treatment support costs in Colombia, 2021. PLoS One. 2024;19(4):e0296250. | eng |
| dcterms.references | Rueda ZV, Herrera-Diaz M, Marin D, Lopez L, Realpe T, Almeida-Rueda LM, et al. Transmission of Mycobacterium tuberculosis in four prisons in Colombia. Epidemiol Infect. 2025 Feb;153:e43. | eng |
| dcterms.references | Benjumea-Bedoya D, Marín DM, Robledo J, Barrera LF, López L, Del Corral H, et al. Risk of infection and disease progression in children exposed to tuberculosis at home, Colombia. Colomb medica (Cali, Colomb. 2019 Dec;50(4):261–74. | eng |
| dcterms.references | Finlayson H, Lishman J, Palmer M. What’s new in childhood tuberculosis. Curr Opin Pediatr. 2023 Apr;35(2):166–75. | eng |
| dcterms.references | World Health Organization. WHO Consolidated Guidelines on Tuberculosis. Module 5: Management of tuberculosis in children and adolescents (2022) y Operational Handbook (2022). World Health Organization, editor. 2022. 128 p. | eng |
| dcterms.references | Benjumea-Bedoya D, Robledo-Restrepo JA, Arbelaez-Montoya MP, Estupiñán-Bohorquez AF, Sabella-Jimenez VS, Restrepo-Gouzy AV, et al. Clinical practice guideline for the evaluation, treatment, and follow-up of children in contact with patients with pulmonary tuberculosis in Colombia. Colomb medica (Cali, Colomb. 2025;56(1):e6005918. | eng |
| dcterms.references | Lin PL, Flynn JL. The End of the Binary Era: Revisiting the Spectrum of Tuberculosis. J Immunol. 2018 Nov;201(9):2541–8. | eng |
| dcterms.references | Boisson-Dupuis S, Bustamante J, El-Baghdadi J, Camcioglu Y, Parvaneh N, El Azbaoui S, et al. Inherited and acquired immunodeficiencies underlying tuberculosis in childhood. Immunol Rev. 2015 Mar;264(1):103–20. | eng |
| dcterms.references | Jaganath D, Beaudry J, Salazar-Austin N. Tuberculosis in Children. Infect Dis Clin North Am. 2022 Mar;36(1):49–71. | eng |
| dcterms.references | Hamdar H, Nahle AA, Ataya J, Jawad A, Salame H, Jaber R, et al. Comparative analysis of pediatric pulmonary and extrapulmonary tuberculosis: A single-center retrospective cohort study in Syria. Heliyon. 2024 Sep;10(17):e36779. | eng |
| dcterms.references | Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, et al. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med. 2015 Jun;3(6):451–61. | eng |
| dcterms.references | Kay AW, González Fernández L, Takwoingi Y, Eisenhut M, Detjen AK, Steingart KR, et al. Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children. Cochrane database Syst Rev. 2020 Aug;8(8):CD013359. | eng |
| dcterms.references | Basile FW, Nabeta P, Ruhwald M, Song R. Pediatric Tuberculosis Diagnostics: Present and Future. J Pediatric Infect Dis Soc. 2022 Oct;11(Supplement_3):S85–93. | eng |
| dcterms.references | Gunasekera KS, Vonasek B, Oliwa J, Triasih R, Lancioni C, Graham SM, et al. Diagnostic Challenges in Childhood Pulmonary Tuberculosis-Optimizing the Clinical Approach. Pathog (Basel, Switzerland). 2022 Mar;11(4). | eng |
| dcterms.references | Palmer M, Gunasekera KS, van der Zalm MM, Morrison J, Simon Schaaf H, Goussard P, et al. The Diagnostic Accuracy of Chest Radiographic Features for Pediatric Intrathoracic Tuberculosis. Clin Infect Dis. 2022 Sep;75(6):1014– 21. | eng |
| dcterms.references | Dubois MM, Brooks MB, Malik AA, Siddiqui S, Ahmed JF, Jaswal M, et al. Age-specific Clinical Presentation and Risk Factors for Extrapulmonary Tuberculosis Disease in Children. Pediatr Infect Dis J. 2022 Aug;41(8):620–5. | eng |
| dcterms.references | Santiago-García B, Blázquez-Gamero D, Baquero-Artigao F, Ruíz-Contreras J, Bellón JM, Muñoz-Fernández MA, et al. Pediatric Extrapulmonary Tuberculosis: Clinical Spectrum, Risk Factors and Diagnostic Challenges in a Low Prevalence Region. Pediatr Infect Dis J. 2016 Nov;35(11):1175–81. | eng |
| dcterms.references | Lee JY, Kwon N, Goo GY, Cho SI. Inadequate housing and pulmonary tuberculosis: a systematic review. BMC Public Health. 2022 Mar;22(1):622. | eng |
| dcterms.references | Siddalingaiah N, Chawla K, Nagaraja SB, Hazra D. Risk factors for the development of tuberculosis among the pediatric population: a systematic review and meta-analysis. Eur J Pediatr. 2023 Jul;182(7):3007–19. | eng |
| dcterms.references | An Y, Teo AKJ, Huot CY, Tieng S, Khun KE, Pheng SH, et al. Barriers to childhood tuberculosis case detection and management in Cambodia: the perspectives of healthcare providers and caregivers. BMC Infect Dis. 2023 Feb;23(1):80. | eng |
| dcterms.references | Wobudeya E, Nanfuka M, Ton Nu Nguyet MH, Taguebue JV, Moh R, Breton G, et al. Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre- post intervention study. EClinicalMedicine. 2024 Apr;70:102527. | eng |
| dcterms.references | Singh S, Chegondi M, Chacham S, Kumar P, Goyal JP. Comparison of clinical and laboratory profile of pulmonary and extrapulmonary tuberculosis in children: A single-center experience from India. J Clin Transl Res. 2021 Aug;7(4):423–7. | eng |
| dcterms.references | Kay AW, Ness T, Verkuijl SE, Viney K, Brands A, Masini T, et al. Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children. Cochrane database Syst Rev. 2022 Sep;9(9):CD013359. | eng |
| dcterms.references | MacLean E, Sulis G, Denkinger CM, Johnston JC, Pai M, Ahmad Khan F. Diagnostic Accuracy of Stool Xpert MTB/RIF for Detection of Pulmonary Tuberculosis in Children: a Systematic Review and Meta-analysis. J Clin Microbiol. 2019 Jun;57(6). | eng |
| dcterms.references | Han C, Fang Y, Dong L, Guo D, Lei M, Guo W, et al. Correlation of tuberculosis-related anemia severity with tuberculosis-induced inflammation in children: a six-year retrospective study. Ital J Pediatr. 2024 Jun;50(1):116. | eng |
| dcterms.references | Vonasek BJ, Radtke KK, Vaz P, Buck WC, Chabala C, McCollum ED, et al. Tuberculosis in children with severe acute malnutrition. Expert Rev Respir Med. 2022 Mar;16(3):273–84. | eng |
| dcterms.references | d’Elbée M, Harker M, Mafirakureva N, Nanfuka M, Huyen Ton Nu Nguyet M, Taguebue JV, et al. Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study. EClinicalMedicine. 2024 Apr;70:102528. | eng |
| dcterms.references | Moges S, Lajore BA. Mortality and associated factors among patients with TB- HIV co-infection in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2024 Aug;24(1):773. | eng |
| dcterms.references | Carlucci JG, Blevins Peratikos M, Kipp AM, Lindegren ML, Du QT, Renner L, et al. Tuberculosis Treatment Outcomes Among HIV/TB-Coinfected Children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Network. J Acquir Immune Defic Syndr. 2017 Jun;75(2):156–63. | eng |
| dcterms.references | Cáceres G, Calderon R, Ugarte-Gil C. Tuberculosis and comorbidities: treatment challenges in patients with comorbid diabetes mellitus and depression. Ther Adv Infect Dis. 2022;9:20499361221095830. | eng |
| dcterms.references | Khattak M, Rehman AU, Muqaddas T, Hussain R, Rasool MF, Saleem Z, et al. Tuberculosis (TB) treatment challenges in TB-diabetes comorbid patients: a systematic review and meta-analysis. Ann Med. 2024 Dec;56(1):2313683. | eng |
| dcterms.references | Nowiński A, Wesołowski S, Korzeniewska-Koseła M. The impact of comorbidities on tuberculosis treatment outcomes in Poland: a national cohort study. Front Public Heal. 2023 Sep;11. | eng |
| dcterms.references | Sun JW, Bourgeois FT, Haneuse S, Hernández-Díaz S, Landon JE, Bateman BT, et al. Development and Validation of a Pediatric Comorbidity Index. Am J Epidemiol. 2021 May;190(5):918–27. | eng |
| dcterms.references | Chung SC, Mueller S, Green K, Chang WH, Hargrave D, Lai AG. Multimorbidity patterns and risk of hospitalisation in children: A population cohort study of 3.6 million children in England, with illustrative examples from childhood cancer survivors. Lancet Reg Heal Eur. 2022 Sep;20:100433. | eng |
| dcterms.references | Saukkonen JJ, Duarte R, Munsiff SS, Winston CA, Mammen MJ, Abubakar I, et al. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline. Am J Respir Crit Care Med. 2025 Jan;211(1):15–33. | eng |
| dcterms.references | Alipanah N, Jarlsberg L, Miller C, Linh NN, Falzon D, Jaramillo E, et al. Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies. PLoS Med. 2018 Jul;15(7):e1002595. | eng |
| dcterms.references | Rodríguez-Márquez I, Benjumea-Bedoya D, Restrepo-Gouzy AV, Beltrán- Arroyave CP, Marín D, Montes-Zuluaga FN, et al. Adherence to treatment for tuberculosis infection in children using a comprehensive care strategy: a prospective cohort study with a historical control group. Lancet Reg Heal Am. 2025 Jun;46:101094. | eng |
| dcterms.references | Prodanuk M, Silverberg SL, Piché-Renaud PP, Farrar DS, Cunningham J, Kritzinger F, et al. Adverse events of first-line therapy for pediatric tuberculosis: A systematic review and meta-analysis. Clin Infect Dis. 2025 Mar; | eng |
| dcterms.references | Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, Mubiri P, et al. Pediatric tuberculosis outcomes and factors associated with unfavorable treatment outcomes in Botswana, 2008-2019: a retrospective analysis. BMC Public Health. 2022 Nov;22(1):2020. | eng |
| dcterms.references | Santos VS, de Holanda JRC, Gois-Neto RDS, Maciel ELN, Johansen FDC, Silva-Júnior JN de B, et al. Social and health factors associated with unfavourable treatment outcomes in children and adolescents with drug- sensitive tuberculosis in Brazil: a national retrospective cohort study. Lancet Reg Heal Am. 2024 Dec;40:100938. | eng |
| dcterms.references | Burusie A, Enquesilassie F, Salazar-Austin N, Addissie A. Epidemiology of childhood tuberculosis and predictors of death among children on tuberculosis treatment in central Ethiopia: an extended Cox model challenged survival analysis. BMC Public Health. 2023 Jul;23(1):1287. | eng |
| dcterms.references | Belay GM, Wubneh CA. Childhood tuberculosis treatment outcome and its association with HIV co-infection in Ethiopia: a systematic review and meta- analysis. Trop Med Health. 2020;48:7. | eng |
| dcterms.references | Ngosa D, Lupenga J. Childhood tuberculosis outcomes and factors associated with unsuccessful treatment outcomes in selected public hospitals of Lusaka Zambia from 2015 to 2019. PLOS Glob public Heal. 2024;4(10):e0002591. | eng |
| dcterms.references | Schober P, Vetter TR. Survival Analysis and Interpretation of Time-to-Event Data: The Tortoise and the Hare. Anesth Analg. 2018 Sep;127(3):792–8. | eng |
| dcterms.references | Ngari MM, Schmitz S, Maronga C, Mramba LK, Vaillant M. A systematic review of the quality of conduct and reporting of survival analyses of tuberculosis outcomes in Africa. BMC Med Res Methodol. 2021 Apr;21(1):89. | eng |
| dcterms.references | Herrera-Olivares MÁ, Donado-Mercado A, Morales-González R, Pérez- Villanueva M, Domínguez-Vargas A, González-Torres HJ. Factores asociados a la adherencia terapéutica y desenlaces clínicos en pacientes con tuberculosis en el Departamento del Atlántico, Colombia (2021-2023). Infectio. 2025 Apr;95–105. | eng |
| dcterms.references | Varela L, Ortiz J, García PK, Luna L, Fuertes-Bucheli JF, Pacheco R. Factores asociados al tratamiento no exitoso para tuberculosis en pacientes previamente tratados en Cali, Colombia, en el periodo 2015-2019. Biomédica. 2023 Sep;43(3):360–73. | eng |
| dcterms.references | Romero G, Cardenas E, Osorio AM. Decomposing the Intraurban Malnutrition Gap Between Poor and Non-poor Children in Colombia : Decomposing the Intraurban Malnutrition Gap Between Poor and Non-poor Children in Colombia. J Urban Health. 2023 Feb;100(1):63–75. | eng |
| dcterms.references | Valencia-Aguirre S, Arroyave I, García-Basteiro AL. Educational level and tuberculosis mortality in Colombia: growing inequalities and stagnation in reduction. Cad Saude Publica. 2022;38(1). | eng |
| dcterms.references | Benjumea-Bedoya D, Villegas Arbeláez E, Martínez-Peñaloza D, Beltrán- Arroyave CP, Restrepo Gouzy AV, Marín D, et al. Implementation of an integrated care strategy for child contacts of tuberculosis patients: a quasi- experimental study protocol. BMC Pediatr. 2023 Jan;23(1):28. | eng |
| dcterms.references | Appiah MA, Gohoho M, Adzaklo EE, Gone GDK, Aniaku JK, Asamoah PE, et al. Spatial distribution of paediatric tuberculosis and factors associated with adverse treatment outcomes in Ashanti Region, Ghana: a retrospective analysis. BMC Pediatr. 2025 May;25(1):418. | eng |
| dcterms.references | Soriano-Arandes A, Brugueras S, Rodríguez Chitiva A, Noguera-Julian A, Orcau À, Martín-Nalda A, et al. Clinical Presentations and Outcomes Related to Tuberculosis in Children Younger Than 2 Years of Age in Catalonia. Front Pediatr. 2019;7:238. | eng |
| dcterms.references | Weldegebreal F, Teklemariam Z, Mitiku H, Tesfaye T, Abrham Roba A, Tebeje F, et al. Treatment outcome of pediatric tuberculosis in eastern Ethiopia. Front Pediatr. 2022;10:966237. | eng |
| dcterms.references | Liang L, Xiong Q, Wei Z, Xie F, Li H, Wu G. Characteristics and predictors of mortality among infants and toddlers hospitalized with tuberculosis: a ten-year case series study in Sichuan, China. BMC Infect Dis. 2025 Jun;25(1):785. | eng |
| dcterms.references | Ockenga J, Fuhse K, Chatterjee S, Malykh R, Rippin H, Pirlich M, et al. Tuberculosis and malnutrition: The European perspective. Clin Nutr. 2023;42(4):486–92. | eng |
| dcterms.references | Wagnew F, Alene KA, Kelly M, Gray D. Undernutrition increases the risk of unsuccessful treatment outcomes of patients with tuberculosis in Ethiopia: A multicenter retrospective cohort study. J Infect. 2024 Jul;89(1):106175. | eng |
| dcterms.references | Dawit Z, Abebe S, Dessu S, Mesele M, Sahile S, Ajema D. Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia. PLoS One. 2021;16(6):e0253449. | eng |
| dcterms.references | Lee JH, Garg T, Lee J, McGrath S, Rosman L, Schumacher SG, et al. Impact of molecular diagnostic tests on diagnostic and treatment delays in tuberculosis: a systematic review and meta-analysis. BMC Infect Dis. 2022 Dec;22(1):940. | eng |
| dcterms.references | Nicol MP, Wood RC, Workman L, Prins M, Whitman C, Ghebrekristos Y, et al. Microbiological diagnosis of pulmonary tuberculosis in children by oral swab polymerase chain reaction. Sci Rep. 2019 Jul;9(1):10789. | eng |
| oaire.version | info:eu-repo/semantics/acceptedVersion | |
| sb.programa | Especialización en Pediatría | spa |
| sb.sede | Sede Barranquilla | spa |
Archivos
Bloque de licencias
1 - 1 de 1
No hay miniatura disponible
- Nombre:
- license.txt
- Tamaño:
- 2.93 KB
- Formato:
- Item-specific license agreed upon to submission
- Descripción: