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Factores clínicos e inmunológicos asociados al rechazo agudo y a la sobrevida del injerto en receptores de trasplante renal en un centro de referencia de Barranquilla (Atl, CO) entre los años 2023-2025

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datacite.rightshttp://purl.org/coar/access_right/c_f1cf
dc.contributor.advisorAroca Martínez, Gustavo
dc.contributor.advisorCadena Bonfanti, Andrés
dc.contributor.advisorGonzález Torres, Henry Joseth
dc.contributor.authorBaleta Plata, Waldy Alberto
dc.date.accessioned2026-02-04T21:42:41Z
dc.date.available2026-02-04T21:42:41Z
dc.date.issued2025
dc.description.abstractEl trasplante renal es la terapia de reemplazo renal de elección en la enfermedad renal crónica terminal; sin embargo, el rechazo agudo del injerto continúa siendo una complicación relevante que afecta la función renal y la sobrevida del injerto. Factores clínicos e inmunológicos, como la sensibilización del receptor, la compatibilidad HLA y el tipo de donante, influyen de manera significativa en el riesgo de rechazo. En el Caribe colombiano, la evidencia local que evalúe de forma integrada estos factores sigue siendo limitada. Objetivo: Evaluar los factores clínicos e inmunológicos asociados al rechazo agudo y su impacto en la sobrevida del injerto renal en receptores de trasplante renal de un centro de referencia de Barranquilla durante el periodo 2023–2025.spa
dc.description.abstractKidney transplantation is the preferred renal replacement therapy for end-stage kidney disease; however, acute graft rejection remains a relevant post-transplant complication that adversely affects renal function and graft survival. Clinical and immunological factors, such as recipient sensitization, HLA compatibility, and donor type, significantly influence the risk of rejection. In the Colombian Caribbean region, local evidence integrating these factors and their impact on graft outcomes remains limited. Objective: To evaluate the clinical and immunological factors associated with acute rejection and their impact on renal graft survival in kidney transplant recipients from a referral center in Barranquilla during the period 2023–2025.eng
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/20.500.12442/17335
dc.language.isospa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.publisherFacultad de Ciencias de la Saludspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationaleng
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTrasplante renalspa
dc.subjectRechazo agudospa
dc.subjectSobrevida del injertospa
dc.subjectCompatibilidad HLAspa
dc.subjectPanel Reactivo de Anticuerposspa
dc.subjectFactores inmunológicosspa
dc.subjectCaribe colombianospa
dc.subject.keywordsKidney transplantationeng
dc.subject.keywordsAcute rejectioneng
dc.subject.keywordsGraft survivaleng
dc.subject.keywordsHLA compatibilityeng
dc.subject.keywordsPanel Reactive Antibodieseng
dc.subject.keywordsImmunological factorseng
dc.subject.keywordsColombian Caribbeaneng
dc.titleFactores clínicos e inmunológicos asociados al rechazo agudo y a la sobrevida del injerto en receptores de trasplante renal en un centro de referencia de Barranquilla (Atl, CO) entre los años 2023-2025spa
dc.type.driverinfo:eu-repo/semantics/other
dc.type.spaOtros
dcterms.referencesWolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999;341:1725–30. https://doi.org/10.1056/NEJM199912023412303.eng
dcterms.referencesTonelli M, Wiebe N, Knoll G, Bello A, Browne S, Jadhav D, et al. Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes. Am J Transplant 2011;11:2093–109. https://doi.org/10.1111/j.1600-6143.2011.03686.x.eng
dcterms.referencesMeier-Kriesche H-U, Schold JD, Srinivas TR, Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004;4:378–83. https://doi.org/10.1111/j.1600-6143.2004.00332.x.eng
dcterms.referencesLamb KE, Lodhi S, Meier-Kriesche H-U. Long-term renal allograft survival in the United States: a critical reappraisal. Am J Transplant 2011;11:450–62. https://doi.org/10.1111/j.1600-6143.2010.03283.x.eng
dcterms.referencesOpelz G, Döhler B. Association between steroid dosage and death with a functioning graft after kidney transplantation. Am J Transplant 2013;13:2096– 105. https://doi.org/10.1111/ajt.12313.eng
dcterms.referencesLoupy A, Lefaucheur C. Antibody-Mediated Rejection of Solid-Organ Allografts. N Engl J Med 2018;379:1150–60. https://doi.org/10.1056/NEJMra1802677.eng
dcterms.referencesTambur AR, Claas FHJ. HLA epitopes as viewed by antibodies: what is it all about? Am J Transplant 2015;15:1148–54. https://doi.org/10.1111/ajt.13192.eng
dcterms.referencesWiebe C, Gibson IW, Blydt-Hansen TD, Pochinco D, Birk PE, Ho J, et al. Rates and determinants of progression to graft failure in kidney allograft recipients with de novo donor-specific antibody. Am J Transplant 2015;15:2921–30. https://doi.org/10.1111/ajt.13347.eng
dcterms.referencesGarcia GG, Harden P, Chapman J, The World Kidney Day Steering Committee 2012. The Global role of kidney transplantation. J Nephropathol 2012;1:69– 76. https://doi.org/10.5812/nephropathol.7448.eng
dcterms.referencesNankivell BJ, Chapman JR. Chronic allograft nephropathy: current concepts and future directions. Transplantation 2006;81:643–54. https://doi.org/10.1097/01.tp.0000190423.82154.01.eng
dcterms.referencesOjo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997;63:968–74. https://doi.org/10.1097/00007890-199704150-00011.eng
dcterms.referencesTerasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995;333:333–6. https://doi.org/10.1056/NEJM199508103330601.eng
dcterms.referencesMuzaale AD, Massie AB, Wang M-C, Montgomery RA, McBride MA, Wainright JL, et al. Risk of end-stage renal disease following live kidney donation. JAMA 2014;311:579–86. https://doi.org/10.1001/jama.2013.285141.eng
dcterms.referencesMatas AJ, Gillingham KJ, Payne WD, Najarian JS. The impact of an acute rejection episode on long-term renal allograft survival (t1/2). Transplantation 1994;57:857–9. https://doi.org/10.1097/00007890-199403270-00015.eng
dcterms.referencesMeier-Kriesche H-U, Schold JD, Kaplan B. Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies? Am J Transplant 2004;4:1289–95. https://doi.org/10.1111/j.1600-6143.2004.00515.x.eng
dcterms.referencesSellarés J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, et al. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant 2012;12:388–99. https://doi.org/10.1111/j.1600-6143.2011.03840.x.eng
dcterms.referencesWiebe C, Nickerson P. Posttransplant monitoring of de novo human leukocyte antigen donor-specific antibodies in kidney transplantation. Curr Opin Organ Transplant 2013;18:470–7. https://doi.org/10.1097/MOT.0b013e3283626149.eng
dcterms.referencesWilliams RC, Opelz G, McGarvey CJ, Weil EJ, Chakkera HA. The Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts From Deceased Donors. Transplantation 2016;100:1094–102. https://doi.org/10.1097/TP.0000000000001115.eng
dcterms.referencesHart A, Lentine KL, Smith JM, Miller JM, Skeans MA, Prentice M, et al. OPTN/SRTR 2019 Annual Data Report: Kidney. Am J Transplant 2021;21 Suppl 2:21–137. https://doi.org/10.1111/ajt.16502.eng
dcterms.referencesGarcia-Garcia G, Jha V, World Kidney Day Steering Committee*. Chronic kidney disease in disadvantaged populations. Brazilian J Med Biol Res = Rev Bras Pesqui Medicas e Biol 2015;48:377–81. https://doi.org/10.1590/1414- 431X20144519.eng
dcterms.referencesReese PP, Boudville N, Garg AX. Living kidney donation: outcomes, ethics, and uncertainty. Lancet (London, England) 2015;385:2003–13. https://doi.org/10.1016/S0140-6736(14)62484-3.eng
dcterms.referencesFrancis A, Harhay MN, Ong ACM, Tummalapalli SL, Ortiz A, Fogo AB, et al. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol 2024;20:473–85. https://doi.org/10.1038/s41581-024-00820-6.eng
dcterms.referencesStrohmaier S, Wallisch C, Kammer M, Geroldinger A, Heinze G, Oberbauer R, et al. Survival Benefit of First Single-Organ Deceased Donor Kidney Transplantation Compared With Long-term Dialysis Across Ages in Transplant-Eligible Patients With Kidney Failure. JAMA Netw Open 2022;5:e2234971. https://doi.org/10.1001/jamanetworkopen.2022.34971.eng
dcterms.referenceshadban SJ, Ahn C, Axelrod DA, Foster BJ, Kasiske BL, Kher V, et al. KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation. Transplantation 2020;104:S11–103. https://doi.org/10.1097/TP.0000000000003136.eng
dcterms.referencesWainstein M, Bello AK, Jha V, Harris DCH, Levin A, Gonzalez-Bedat MC, et al. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Latin America. Kidney Int Suppl 2021;11:e35–46. https://doi.org/10.1016/j.kisu.2021.01.005.eng
dcterms.referencesLim WH, Wong G, Heidt S, Claas FHJ. Novel aspects of epitope matching and practical application in kidney transplantation. Kidney Int 2018;93:314–24. https://doi.org/10.1016/j.kint.2017.08.008.eng
dcterms.referencesSenev A, Coemans M, Lerut E, Van Sandt V, Kerkhofs J, Daniëls L, et al. Eplet Mismatch Load and De Novo Occurrence of Donor-Specific Anti-HLA Antibodies, Rejection, and Graft Failure after Kidney Transplantation: An Observational Cohort Study. J Am Soc Nephrol 2020;31:2193–204. https://doi.org/10.1681/ASN.2020010019.eng
dcterms.referencesSchinstock CA, Smith BH, Montgomery RA, Jordan SC, Bentall AJ, Mai M, et al. Managing highly sensitized renal transplant candidates in the era of kidney paired donation and the new kidney allocation system: Is there still a role for desensitization? Clin Transplant 2019;33:e13751. https://doi.org/10.1111/ctr.13751.eng
dcterms.referencesLoupy A, Haas M, Roufosse C, Naesens M, Adam B, Afrouzian M, et al. The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell- and antibody-mediated rejection. Am J Transplant 2020;20:2318– 31. https://doi.org/10.1111/ajt.15898.eng
dcterms.referencesSchinstock CA, Mannon RB, Budde K, Chong AS, Haas M, Knechtle S, et al. Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group. Transplantation 2020;104:911–22. https://doi.org/10.1097/TP.0000000000003095.eng
dcterms.referencesWiebe C, Pochinco D, Blydt-Hansen TD, Ho J, Birk PE, Karpinski M, et al. Class II HLA epitope matching-A strategy to minimize de novo donor-specific antibody development and improve outcomes. Am J Transplant 2013;13:3114–22. https://doi.org/10.1111/ajt.12478.eng
dcterms.referencesSummers DM, Johnson RJ, Allen J, Fuggle S V, Collett D, Watson CJ, et al. Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study. Lancet (London, England) 2010;376:1303–11. https://doi.org/10.1016/S0140-6736(10)60827-6.eng
dcterms.referencesHariharan S, Israni AK, Danovitch G. Long-Term Survival after Kidney Transplantation. N Engl J Med 2021;385:729–43. https://doi.org/10.1056/NEJMra2014530.eng
dcterms.referencesWan SS, Chadban SJ, Watson N, Wyburn K. Development and outcomes of de novo donor-specific antibodies in low, moderate, and high immunological risk kidney transplant recipients. Am J Transplant 2020;20:1351–64. https://doi.org/10.1111/ajt.15754.eng
dcterms.referencesForoutan F, Friesen EL, Clark KE, Motaghi S, Zyla R, Lee Y, et al. Risk Factors for 1-Year Graft Loss After Kidney Transplantation: Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol 2019;14:1642–50. https://doi.org/10.2215/CJN.05560519.eng
dcterms.referencesLentine KL, Smith JM, Lyden GR, Miller JM, Dolan TG, Bradbrook K, et al. OPTN/SRTR 2022 Annual Data Report: Kidney. Am J Transplant 2024;24:S19–118. https://doi.org/10.1016/j.ajt.2024.01.012.eng
dcterms.referencesNieto-Ríos JF, Ochoa-García CL, Serna-Campuzano A, Benavides-Hermosa B, Calderón-Puentes LL, Aristizabal-Alzate A, et al. Time of Cold Ischemia and Delayed Graft Function in a Cohort of Renal Transplant Patients in a Reference Center. Indian J Nephrol 2019;29:8–14. https://doi.org/10.4103/ijn.IJN_162_18.eng
dcterms.referencesSenev A, Coemans M, Lerut E, Van Sandt V, Daniëls L, Kuypers D, et al. Histological picture of antibody-mediated rejection without donor-specific antiHLA antibodies: Clinical presentation and implications for outcome. Am J Transplant 2019;19:763–80. https://doi.org/10.1111/ajt.15074.eng
dcterms.referencesNakada Y, Yamamoto I, Horita S, Kobayashi A, Mafune A, Katsumata H, et al. The prognostic values of caveolin‐1 immunoreactivity in peritubular capillaries in patients with kidney transplantation. Clin Transplant 2016;30:1417–24. https://doi.org/10.1111/ctr.12833.eng
dcterms.referencesGondos A, Döhler B, Brenner H, Opelz G. Kidney graft survival in Europe and the United States: strikingly different long-term outcomes. Transplantation 2013;95:267–74. https://doi.org/10.1097/TP.0b013e3182708ea8.eng
oaire.versioninfo:eu-repo/semantics/acceptedVersion
sb.programaEspecialización en Nefrologíaspa
sb.sedeSede Barranquillaspa

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