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Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?

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datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
dc.contributor.authorSalazar, Juan
dc.contributor.authorRojas-Quintero, Joselyn
dc.contributor.authorCano, Clímaco
dc.contributor.authorPérez, José L.
dc.contributor.authorRamírez, Paola
dc.contributor.authorCarrasquero, Rubén
dc.contributor.authorTorres, Wheeler
dc.contributor.authorEspinoza, Cristobal
dc.contributor.authorChacín-González, Maricarmen
dc.contributor.authorBermúdez, Valmore
dc.date.accessioned2021-10-25T22:46:34Z
dc.date.available2021-10-25T22:46:34Z
dc.date.issued2020
dc.description.abstractArterial hypertension is the most prevalent chronic disease in the adult population of developed countries and it constitutes a significant risk factor in the development of cardiovascular disease, contributing to the emergence of many comorbidities, among which heart failure excels, a clinical syndrome that nowadays represents a major health problem with uncountable hospitalizations and the indolent course of which progressively worsens until quality of life decreases and lastly death occurs prematurely. In the light of this growing menace, each day more efforts are invested in the field of cardiovascular pharmacology, searching for new therapeutic options that allow us to modulate the physiological systems that appear among these pathologies. Therefore, in the later years, the study of natriuretic peptides has become so relevant, which mediate beneficial effects at the cardiovascular level such as diuresis, natriuresis, and decreasing cardiac remodeling; their metabolism is mediated by neprilysin, a metalloproteinase, widely expressed in the human and capable of catalyzing many substrates. The modulation of these functions has been studied by decades, giving room to Sacubitril, the first neprilysin inhibitor, which in conjunction with an angiotensin receptor blocker has provided a high efficacy and tolerability among patients with heart failure, for whom it has already been approved and recommended. Nonetheless, in the matter of arterial hypertension, significant findings have arisen that demonstrate the potential role that it will play among the pharmacological alternatives in the upcoming years.eng
dc.format.mimetypepdfspa
dc.identifier.doihttp://doi.org/10.2174/1573403X15666190625160352
dc.identifier.issn18756557
dc.identifier.urihttps://hdl.handle.net/20.500.12442/8783
dc.language.isoengeng
dc.publisherBentham Science Publisherseng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceCurrent Cardiology Reviewseng
dc.sourceVol. 16, Issue 1 (2020)
dc.subjectArterial hypertensioneng
dc.subjectHeart failureeng
dc.subjectNeprilysineng
dc.subjectNatriuretic peptideseng
dc.subjectSacubitrileng
dc.subjectPharmacologyeng
dc.titleNeprilysin: A Potential Therapeutic Target of Arterial Hypertension?eng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.spaArtículo científicospa
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