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Desempeño neuropsicológico según las combinaciones diagnósticas del síndrome metabólico en adultos mayores

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datacite.rightshttp://purl.org/coar/access_right/c_f1cf
dc.contributor.advisorBermúdez Pirela, Valmore José
dc.contributor.advisorGravini Donado, Marbel
dc.contributor.authorDíaz Camargo, Edgar Alexis
dc.date.accessioned2024-11-14T14:28:49Z
dc.date.available2024-11-14T14:28:49Z
dc.date.issued2024
dc.description.abstractAntecedentes: El envejecimiento es un proceso natural del ciclo vital que ha cobrado gran relevancia en los últimos 30 años debido al incremento progresivo en la expectativa de vida del ser humano. Asimismo, una cantidad importante de estudios ha asociado el Síndrome Metabólico (SM) con un mayor riesgo de declive cognitivo, aunque algunos otros han arrojado resultados no concluyentes. Por este motivo, el objetivo de este estudio es determinar si existe relación entre el rendimiento cognitivo de adultos mayores participantes de los ciclos 2011 a 2014 en el estudio NHANES y SM, incluyendo sus diferentes combinaciones diagnósticas. Para este fin, se realizó una primera fase de investigación documental profunda de la literatura científica en relación con el tema y posteriormente se procedió al diseño y redacción de dos artículos que han sido publicados en revistas de investigación. Estos dos trabajos versan sobre la evolución del concepto de SM y los mecanismos fisiopatológicos compartidos entre el declive cognitivo, la enfermedad de Alzheimer (EA) y el SM, profundizando en las posibles alteraciones de la señalización de la insulina y los defectos en el transporte de glucosa en el sistema nervioso central, como parte de los posibles mecanismos moleculares relacionados con el declive cognitivo y el desarrollo de EA. En la segunda fase de este estudio se investigó la relación entre el deterioro en el desempeño neuropsicológico de adultos mayores y el diagnóstico de SM, incluyendo sus diferentes combinaciones diagnósticas. Objetivos: Determinar si existe relación entre el rendimiento cognitivo de adultos mayores participantes de los ciclos 2011 a 2014 en el estudio NHANES y el síndrome metabólico, incluyendo sus diferentes combinaciones diagnósticas. Materiales y Métodos: Este trabajo consiste en un compendio de artículos que han sido publicados en revistas de investigación. En los cuales los dos primeros artículos son de revisión y en el tercer artículo se realizó un estudio no experimental de tipo transversal, de alcance comparativo y correlacional, que se llevó a cabo sobre una muestra de 3179 adultos mayores de 60 años de la Encuesta Nacional de Examen de Salud y Nutrición (NHANES) de 2011-2014 para analizar la relación entre el síndrome metabólico y el deterioro cognitivo. La composición de estas dos cohortes tiene las siguientes características demográficas: el 48.51% (n=1542) son hombres y el 51.49% (n=1637) son mujeres, siendo la media aritmética de la edad para ambos sexos de 69.48±6.78 (CV=9.76%) años.spa
dc.description.abstractBackground: Aging is a natural process of the life cycle that has gained great relevance in the last 30 years due to the progressive increase in human life expectancy. Likewise, a significant number of studies have associated Metabolic Syndrome (MS) with a greater risk of cognitive decline, although some others have yielded inconclusive results. For this reason, the objective of this study is to determine if there is a relationship between the cognitive performance of older adults participating in the 2011 to 2014 cycles in the NHANES and SM studies, including their different diagnostic combinations. For this purpose, a first phase of in -depth documentary research of the scientific literature related to the topic was carried out and subsequently the design and writing of two articles that have been published in research journals were carried out. These two works deal with the evolution of the concept of MS and the pathophysiological mechanisms shared between cognitive decline, Alzheimer's disease (AD) and MS, delving into possible alterations in insulin signaling and defects in insulin transport. glucose in the central nervous system, as part of the possible molecular mechanisms related to cognitive decline and the development of AD. In the second phase of this study, the relationship between the deterioration in the neuropsychological performance of older adults and the diagnosis of MS was investigated, including its different diagnostic combinations. Objective: To determine if there is a relationship between the cognitive performance of older adults participating in the 2011 to 2014 cycles in the NHANES study and metabolic syndrome, including its different diagnostic combinations. Materials and Methods: This work consists of a compendium of articles that have been published in research journals. In which the first two articles are reviews and in the third article a non-experimental cross-sectional study, of comparative and correlational scope, was carried out on a sample of 3,179 adults over 60 years of age from the National Survey. Health and Nutrition Examination Survey (NHANES) from 2011-2014 to analyze the relationship between metabolic syndrome and cognitive impairment. The composition of these two cohorts has the following demographic characteristics: 48.51% (n=1542) are men and 51.49% (n=1637) are women, with the arithmetic mean age for both sexes being 69.48±6.78 (CV =9.76%) years.eng
dc.format.mimetypepdf
dc.identifier.urihttps://hdl.handle.net/20.500.12442/15940
dc.language.isospa
dc.publisherEdiciones Universidad Simón Bolívarspa
dc.publisherFacultad de Ciencias Jurídicas y Socialesspa
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United Stateseng
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.subjectEnvejecimientospa
dc.subjectSíndrome Metabólicospa
dc.subjectDisfunción cognitivaspa
dc.subjectEnfermedad de Alzheimerspa
dc.subject.keywordsAgingeng
dc.subject.keywordsMetabolic syndromeeng
dc.subject.keywordsCognitive dysfunctioneng
dc.subject.keywordsAlzheimer diseaseeng
dc.titleDesempeño neuropsicológico según las combinaciones diagnósticas del síndrome metabólico en adultos mayoresspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.spaTesis de doctorado
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